Citomegalovirus: monitoraggio dell’infezione e della terapia nei pazienti trapiantati di rene
CMV infection is a major cause of disease following renal transplantation. Clinical diagnosis is difficult because the virus usually produces only few, if any, symptoms. Consequently rapid and sensitive diagnostic methods are needed, since clinically effective antiviral therapy is available. Qualita...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2003-12-01
|
| Series: | Microbiologia Medica |
| Subjects: | |
| Online Access: | http://www.pagepressjournals.org/index.php/mm/article/view/3031 |
| _version_ | 1818059166141382656 |
|---|---|
| author | Nicola Liritano Maria Gabriella Lepore Rosangela De Grazia Elio De Fazio Rosanna Masciari Gianfranco Merando Isolina Mantelli Luigi Lombardi Paolo Scerbo Lucio Cosco Teresa Ferraro Caterina Filia Ignazio Vasapollo |
| author_facet | Nicola Liritano Maria Gabriella Lepore Rosangela De Grazia Elio De Fazio Rosanna Masciari Gianfranco Merando Isolina Mantelli Luigi Lombardi Paolo Scerbo Lucio Cosco Teresa Ferraro Caterina Filia Ignazio Vasapollo |
| author_sort | Nicola Liritano |
| collection | DOAJ |
| description | CMV infection is a major cause of disease following renal transplantation. Clinical diagnosis is difficult because the virus usually produces only few, if any, symptoms. Consequently rapid and sensitive diagnostic methods are needed, since clinically effective antiviral therapy is available. Qualitative-quantitative detection of CMV-DNA in leukocytes and in plasma and pp65-antigenaemia are the methods which allow to evidence viral replication activity. In this study we report the our experience about follow-up of 70 kidney transplant recipients. Results indicate that while active CMV infection occured in 25 patients (37,5%), only 11 patients (15,7%) showed antigenaemia and DNAemia values predictive of CMV disease. In this study we also evaluated the efficacy of pre-emptive therapy. |
| first_indexed | 2024-12-10T13:12:12Z |
| format | Article |
| id | doaj.art-aa271d44201c4d6d9003444d31344449 |
| institution | Directory Open Access Journal |
| issn | 2280-6423 |
| language | English |
| last_indexed | 2024-12-10T13:12:12Z |
| publishDate | 2003-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Microbiologia Medica |
| spelling | doaj.art-aa271d44201c4d6d9003444d313444492022-12-22T01:47:39ZengPAGEPress PublicationsMicrobiologia Medica2280-64232003-12-0118410.4081/mm.2003.30312279Citomegalovirus: monitoraggio dell’infezione e della terapia nei pazienti trapiantati di reneNicola LiritanoMaria Gabriella LeporeRosangela De GraziaElio De FazioRosanna MasciariGianfranco MerandoIsolina MantelliLuigi LombardiPaolo ScerboLucio CoscoTeresa FerraroCaterina FiliaIgnazio VasapolloCMV infection is a major cause of disease following renal transplantation. Clinical diagnosis is difficult because the virus usually produces only few, if any, symptoms. Consequently rapid and sensitive diagnostic methods are needed, since clinically effective antiviral therapy is available. Qualitative-quantitative detection of CMV-DNA in leukocytes and in plasma and pp65-antigenaemia are the methods which allow to evidence viral replication activity. In this study we report the our experience about follow-up of 70 kidney transplant recipients. Results indicate that while active CMV infection occured in 25 patients (37,5%), only 11 patients (15,7%) showed antigenaemia and DNAemia values predictive of CMV disease. In this study we also evaluated the efficacy of pre-emptive therapy.http://www.pagepressjournals.org/index.php/mm/article/view/3031renal transplant, CMV infectious diagnosis, pre-emptive therapy. |
| spellingShingle | Nicola Liritano Maria Gabriella Lepore Rosangela De Grazia Elio De Fazio Rosanna Masciari Gianfranco Merando Isolina Mantelli Luigi Lombardi Paolo Scerbo Lucio Cosco Teresa Ferraro Caterina Filia Ignazio Vasapollo Citomegalovirus: monitoraggio dell’infezione e della terapia nei pazienti trapiantati di rene Microbiologia Medica renal transplant, CMV infectious diagnosis, pre-emptive therapy. |
| title | Citomegalovirus: monitoraggio dell’infezione e della terapia nei pazienti trapiantati di rene |
| title_full | Citomegalovirus: monitoraggio dell’infezione e della terapia nei pazienti trapiantati di rene |
| title_fullStr | Citomegalovirus: monitoraggio dell’infezione e della terapia nei pazienti trapiantati di rene |
| title_full_unstemmed | Citomegalovirus: monitoraggio dell’infezione e della terapia nei pazienti trapiantati di rene |
| title_short | Citomegalovirus: monitoraggio dell’infezione e della terapia nei pazienti trapiantati di rene |
| title_sort | citomegalovirus monitoraggio dell infezione e della terapia nei pazienti trapiantati di rene |
| topic | renal transplant, CMV infectious diagnosis, pre-emptive therapy. |
| url | http://www.pagepressjournals.org/index.php/mm/article/view/3031 |
| work_keys_str_mv | AT nicolaliritano citomegalovirusmonitoraggiodellinfezioneedellaterapianeipazientitrapiantatidirene AT mariagabriellalepore citomegalovirusmonitoraggiodellinfezioneedellaterapianeipazientitrapiantatidirene AT rosangeladegrazia citomegalovirusmonitoraggiodellinfezioneedellaterapianeipazientitrapiantatidirene AT eliodefazio citomegalovirusmonitoraggiodellinfezioneedellaterapianeipazientitrapiantatidirene AT rosannamasciari citomegalovirusmonitoraggiodellinfezioneedellaterapianeipazientitrapiantatidirene AT gianfrancomerando citomegalovirusmonitoraggiodellinfezioneedellaterapianeipazientitrapiantatidirene AT isolinamantelli citomegalovirusmonitoraggiodellinfezioneedellaterapianeipazientitrapiantatidirene AT luigilombardi citomegalovirusmonitoraggiodellinfezioneedellaterapianeipazientitrapiantatidirene AT paoloscerbo citomegalovirusmonitoraggiodellinfezioneedellaterapianeipazientitrapiantatidirene AT luciocosco citomegalovirusmonitoraggiodellinfezioneedellaterapianeipazientitrapiantatidirene AT teresaferraro citomegalovirusmonitoraggiodellinfezioneedellaterapianeipazientitrapiantatidirene AT caterinafilia citomegalovirusmonitoraggiodellinfezioneedellaterapianeipazientitrapiantatidirene AT ignaziovasapollo citomegalovirusmonitoraggiodellinfezioneedellaterapianeipazientitrapiantatidirene |