Breast cancer anti-hormonal therapy and rheumatic diseases: linking the clinical to molecular world
Anti-hormonal therapies are used in the treatment of hormone dependent breast cancer. Their use may be complicated with the onset of arthralgia and autoimmune diseases. Recently a clinical relationship between oestrogen, anti-oestrogen therapy and rheumatic diseases has been reported in the literatu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Verduci Editore
2020-04-01
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| Series: | Beyond Rheumatology |
| Subjects: | |
| Online Access: | https://www.beyond-rheumatology.org/wp-content/uploads/sites/10/2022/05/br-2-1-30.pdf |
| _version_ | 1797831419331870720 |
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| author | Nadia Melillo Francesco Paolo Cantatore |
| author_facet | Nadia Melillo Francesco Paolo Cantatore |
| author_sort | Nadia Melillo |
| collection | DOAJ |
| description | Anti-hormonal therapies are used in the treatment of hormone dependent breast cancer. Their use may be complicated with the onset of arthralgia and autoimmune diseases. Recently a clinical relationship between oestrogen, anti-oestrogen therapy and rheumatic diseases has been reported in the literature, but, until now, experimental supporting data about the interacting biochemical pathways involved are still very limited. The understanding of this molecular link may provide important information to elucidate the relationship between autoimmunity and cancer mechanism and treatment.
This review is intended to highlight the relationship between known common molecular mechanisms which explain this association and that probably need to be investigated in future studies. |
| first_indexed | 2024-04-09T13:51:44Z |
| format | Article |
| id | doaj.art-aa2900ad72d94a53a1535c9b69950820 |
| institution | Directory Open Access Journal |
| issn | 2612-5110 |
| language | English |
| last_indexed | 2024-04-09T13:51:44Z |
| publishDate | 2020-04-01 |
| publisher | Verduci Editore |
| record_format | Article |
| series | Beyond Rheumatology |
| spelling | doaj.art-aa2900ad72d94a53a1535c9b699508202023-05-08T14:41:24ZengVerduci EditoreBeyond Rheumatology2612-51102020-04-01210.4081/br.2020.30269Breast cancer anti-hormonal therapy and rheumatic diseases: linking the clinical to molecular worldNadia MelilloFrancesco Paolo CantatoreAnti-hormonal therapies are used in the treatment of hormone dependent breast cancer. Their use may be complicated with the onset of arthralgia and autoimmune diseases. Recently a clinical relationship between oestrogen, anti-oestrogen therapy and rheumatic diseases has been reported in the literature, but, until now, experimental supporting data about the interacting biochemical pathways involved are still very limited. The understanding of this molecular link may provide important information to elucidate the relationship between autoimmunity and cancer mechanism and treatment. This review is intended to highlight the relationship between known common molecular mechanisms which explain this association and that probably need to be investigated in future studies.https://www.beyond-rheumatology.org/wp-content/uploads/sites/10/2022/05/br-2-1-30.pdfbreast cancerrheumatic diseasesanti-hormonal therapyaromatase inhibitors |
| spellingShingle | Nadia Melillo Francesco Paolo Cantatore Breast cancer anti-hormonal therapy and rheumatic diseases: linking the clinical to molecular world Beyond Rheumatology breast cancer rheumatic diseases anti-hormonal therapy aromatase inhibitors |
| title | Breast cancer anti-hormonal therapy and rheumatic diseases: linking the clinical to molecular world |
| title_full | Breast cancer anti-hormonal therapy and rheumatic diseases: linking the clinical to molecular world |
| title_fullStr | Breast cancer anti-hormonal therapy and rheumatic diseases: linking the clinical to molecular world |
| title_full_unstemmed | Breast cancer anti-hormonal therapy and rheumatic diseases: linking the clinical to molecular world |
| title_short | Breast cancer anti-hormonal therapy and rheumatic diseases: linking the clinical to molecular world |
| title_sort | breast cancer anti hormonal therapy and rheumatic diseases linking the clinical to molecular world |
| topic | breast cancer rheumatic diseases anti-hormonal therapy aromatase inhibitors |
| url | https://www.beyond-rheumatology.org/wp-content/uploads/sites/10/2022/05/br-2-1-30.pdf |
| work_keys_str_mv | AT nadiamelillo breastcancerantihormonaltherapyandrheumaticdiseaseslinkingtheclinicaltomolecularworld AT francescopaolocantatore breastcancerantihormonaltherapyandrheumaticdiseaseslinkingtheclinicaltomolecularworld |