The risk of cardiovascular disease and stroke in survivors of head and neck cancer in Korea
Abstract Background Head and neck cancer (HNCA) survivors have a high risk of developing cardiovascular disease (CVD) or stroke because of sharing risk factors of disease. Therefore, we investigated the risk of CVD or stroke occurrence among HNCA survivors in Korea based on the Health Insurance Revi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-03-01
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| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.517 |
| _version_ | 1797224960079429632 |
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| author | Eun Joo Kang Yun‐Gyoo Lee Minji Koo Kyoungmin Lee In Hae Park Jung Sun Kim Yoon Ji Choi |
| author_facet | Eun Joo Kang Yun‐Gyoo Lee Minji Koo Kyoungmin Lee In Hae Park Jung Sun Kim Yoon Ji Choi |
| author_sort | Eun Joo Kang |
| collection | DOAJ |
| description | Abstract Background Head and neck cancer (HNCA) survivors have a high risk of developing cardiovascular disease (CVD) or stroke because of sharing risk factors of disease. Therefore, we investigated the risk of CVD or stroke occurrence among HNCA survivors in Korea based on the Health Insurance Review and Assessment (HIRA) Service claims database. Methods We retrieved claims data of patients who were diagnosed with HNCA in 2014‐2015 using ICD‐10 code and followed up data until 2018. Patients with newly diagnosed with CVD or stroke after HNCA diagnosis during the follow‐up period were detected. We analyzed the characteristics of patients with HNCA who were subsequently diagnosed with CVD or stroke. In addition, the risk factors of CVD or stroke occurrence were investigated using Cox proportional hazard regression analysis. Results Among the 8288 patients with HNCA, 477 and 404 patients were diagnosed with new‐onset CVD and stroke, respectively. Patients with hypertension, diabetes mellitus (DM), and hyperlipidemia had a 3.25‐fold higher risk of CVD comparing to patients without any underlying disease (95% confidence index [CI], 2.38‐4.45) Patients with three underlying diseases had a 2.92‐fold higher risk of stroke compared to patients without any underlying disease (95% CI 2.03‐4.21). Conclusions HNCA survivors with hypertension, DM, and hyperlipidemia should be cautious of the risks of CVD and stroke. |
| first_indexed | 2024-03-12T13:33:32Z |
| format | Article |
| id | doaj.art-aa294860ba8042b683fecfc3b21623a2 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-04-24T14:01:25Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-aa294860ba8042b683fecfc3b21623a22024-04-03T12:41:03ZengWileyHealth Science Reports2398-88352022-03-0152n/an/a10.1002/hsr2.517The risk of cardiovascular disease and stroke in survivors of head and neck cancer in KoreaEun Joo Kang0Yun‐Gyoo Lee1Minji Koo2Kyoungmin Lee3In Hae Park4Jung Sun Kim5Yoon Ji Choi6Department of Internal Medicine Korea University Guro Hospital, Korea University College of Medicine Seoul Republic of KoreaDepartment of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul Republic of KoreaSmart Healthcare Center Korea University Guro Hospital Seoul Republic of KoreaDepartment of Internal Medicine Korea University Guro Hospital, Korea University College of Medicine Seoul Republic of KoreaDepartment of Internal Medicine Korea University Guro Hospital, Korea University College of Medicine Seoul Republic of KoreaDepartment of Internal Medicine, Korea University Ansan Hospital Korea University College of Medicine Ansan Republic of KoreaDepartment of Internal Medicine, Korea University Anam Hospital Korea University College of Medicine Seoul Republic of KoreaAbstract Background Head and neck cancer (HNCA) survivors have a high risk of developing cardiovascular disease (CVD) or stroke because of sharing risk factors of disease. Therefore, we investigated the risk of CVD or stroke occurrence among HNCA survivors in Korea based on the Health Insurance Review and Assessment (HIRA) Service claims database. Methods We retrieved claims data of patients who were diagnosed with HNCA in 2014‐2015 using ICD‐10 code and followed up data until 2018. Patients with newly diagnosed with CVD or stroke after HNCA diagnosis during the follow‐up period were detected. We analyzed the characteristics of patients with HNCA who were subsequently diagnosed with CVD or stroke. In addition, the risk factors of CVD or stroke occurrence were investigated using Cox proportional hazard regression analysis. Results Among the 8288 patients with HNCA, 477 and 404 patients were diagnosed with new‐onset CVD and stroke, respectively. Patients with hypertension, diabetes mellitus (DM), and hyperlipidemia had a 3.25‐fold higher risk of CVD comparing to patients without any underlying disease (95% confidence index [CI], 2.38‐4.45) Patients with three underlying diseases had a 2.92‐fold higher risk of stroke compared to patients without any underlying disease (95% CI 2.03‐4.21). Conclusions HNCA survivors with hypertension, DM, and hyperlipidemia should be cautious of the risks of CVD and stroke.https://doi.org/10.1002/hsr2.517cardiovascular diseasehead and neck cancerriskstrokesurvivorship |
| spellingShingle | Eun Joo Kang Yun‐Gyoo Lee Minji Koo Kyoungmin Lee In Hae Park Jung Sun Kim Yoon Ji Choi The risk of cardiovascular disease and stroke in survivors of head and neck cancer in Korea Health Science Reports cardiovascular disease head and neck cancer risk stroke survivorship |
| title | The risk of cardiovascular disease and stroke in survivors of head and neck cancer in Korea |
| title_full | The risk of cardiovascular disease and stroke in survivors of head and neck cancer in Korea |
| title_fullStr | The risk of cardiovascular disease and stroke in survivors of head and neck cancer in Korea |
| title_full_unstemmed | The risk of cardiovascular disease and stroke in survivors of head and neck cancer in Korea |
| title_short | The risk of cardiovascular disease and stroke in survivors of head and neck cancer in Korea |
| title_sort | risk of cardiovascular disease and stroke in survivors of head and neck cancer in korea |
| topic | cardiovascular disease head and neck cancer risk stroke survivorship |
| url | https://doi.org/10.1002/hsr2.517 |
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