Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach
In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically c...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/12/7/653 |
| _version_ | 1797562864924360704 |
|---|---|
| author | Xavier Buol Koen Robeyns Camila Caro Garrido Nikolay Tumanov Laurent Collard Johan Wouters Tom Leyssens |
| author_facet | Xavier Buol Koen Robeyns Camila Caro Garrido Nikolay Tumanov Laurent Collard Johan Wouters Tom Leyssens |
| author_sort | Xavier Buol |
| collection | DOAJ |
| description | In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API). |
| first_indexed | 2024-03-10T18:34:47Z |
| format | Article |
| id | doaj.art-aa29a5f9ed88451f91e54de5f56b9475 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T18:34:47Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-aa29a5f9ed88451f91e54de5f56b94752023-11-20T06:20:50ZengMDPI AGPharmaceutics1999-49232020-07-0112765310.3390/pharmaceutics12070653Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization ApproachXavier Buol0Koen Robeyns1Camila Caro Garrido2Nikolay Tumanov3Laurent Collard4Johan Wouters5Tom Leyssens6Institute of Condensed Matter and Nanosciences, UCLouvain, 1 Place Louis Pasteur, B-1348 Louvain-la-Neuve, BelgiumInstitute of Condensed Matter and Nanosciences, UCLouvain, 1 Place Louis Pasteur, B-1348 Louvain-la-Neuve, BelgiumInstitute of Condensed Matter and Nanosciences, UCLouvain, 1 Place Louis Pasteur, B-1348 Louvain-la-Neuve, BelgiumNamur Research Institute for Life Sciences (Narilis), Chemistry Department, UNamur, 61 rue de Bruxelles, B-5000 Namur, BelgiumInstitute of Condensed Matter and Nanosciences, UCLouvain, 1 Place Louis Pasteur, B-1348 Louvain-la-Neuve, BelgiumNamur Research Institute for Life Sciences (Narilis), Chemistry Department, UNamur, 61 rue de Bruxelles, B-5000 Namur, BelgiumInstitute of Condensed Matter and Nanosciences, UCLouvain, 1 Place Louis Pasteur, B-1348 Louvain-la-Neuve, BelgiumIn this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API).https://www.mdpi.com/1999-4923/12/7/653nefiracetamsolid statecocrystalssolubilitydissolution ratestability |
| spellingShingle | Xavier Buol Koen Robeyns Camila Caro Garrido Nikolay Tumanov Laurent Collard Johan Wouters Tom Leyssens Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach Pharmaceutics nefiracetam solid state cocrystals solubility dissolution rate stability |
| title | Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach |
| title_full | Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach |
| title_fullStr | Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach |
| title_full_unstemmed | Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach |
| title_short | Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach |
| title_sort | improving nefiracetam dissolution and solubility behavior using a cocrystallization approach |
| topic | nefiracetam solid state cocrystals solubility dissolution rate stability |
| url | https://www.mdpi.com/1999-4923/12/7/653 |
| work_keys_str_mv | AT xavierbuol improvingnefiracetamdissolutionandsolubilitybehaviorusingacocrystallizationapproach AT koenrobeyns improvingnefiracetamdissolutionandsolubilitybehaviorusingacocrystallizationapproach AT camilacarogarrido improvingnefiracetamdissolutionandsolubilitybehaviorusingacocrystallizationapproach AT nikolaytumanov improvingnefiracetamdissolutionandsolubilitybehaviorusingacocrystallizationapproach AT laurentcollard improvingnefiracetamdissolutionandsolubilitybehaviorusingacocrystallizationapproach AT johanwouters improvingnefiracetamdissolutionandsolubilitybehaviorusingacocrystallizationapproach AT tomleyssens improvingnefiracetamdissolutionandsolubilitybehaviorusingacocrystallizationapproach |