Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach

Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach

In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically c...

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Bibliographic Details
Main Authors: Xavier Buol, Koen Robeyns, Camila Caro Garrido, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
nefiracetam
solid state
cocrystals
solubility
dissolution rate
stability
Online Access:https://www.mdpi.com/1999-4923/12/7/653

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