Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study
Abstract Clear cell renal cell carcinoma is a common malignant tumor of the urinary system. The mechanism of its occurrence and development is unknown, and there is currently few effective comprehensive predictive markers for prognosis and treatment response. With the discovery of a new cell death p...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-022-10278-z |
| _version_ | 1798044383067504640 |
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| author | Dian Xia Qi Liu Wen Jiao Longfei Peng Qi Wang ZhouTing Tuo Liangkuan Bi |
| author_facet | Dian Xia Qi Liu Wen Jiao Longfei Peng Qi Wang ZhouTing Tuo Liangkuan Bi |
| author_sort | Dian Xia |
| collection | DOAJ |
| description | Abstract Clear cell renal cell carcinoma is a common malignant tumor of the urinary system. The mechanism of its occurrence and development is unknown, and there is currently few effective comprehensive predictive markers for prognosis and treatment response. With the discovery of a new cell death process – cuproptosis drew the attention of researchers. We constructed a model for the prediction of clinical prognosis and immunotherapy response through integrative analysis of gene expression datasets from KIRC samples in The Cancer Genome Atlas (TCGA) database. During the course of the study, we found that cuproptosis genes are significantly differentially expressed between clear cell renal cell carcinoma samples and normal samples. Based on this, we put forward the prognostic model for cuproptosis gene related-long non-coding RNA. And through various statistic and external independent cohorts, we proved that the model is accurate and stable, worthy of clinical application and further exploration and validation. |
| first_indexed | 2024-04-11T23:02:53Z |
| format | Article |
| id | doaj.art-aa2e1754d19a4b6a9b88a5dc6feab698 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-11T23:02:53Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-aa2e1754d19a4b6a9b88a5dc6feab6982022-12-22T03:58:06ZengBMCBMC Cancer1471-24072022-11-0122111610.1186/s12885-022-10278-zExploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics studyDian Xia0Qi Liu1Wen Jiao2Longfei Peng3Qi Wang4ZhouTing Tuo5Liangkuan Bi6Department of Urology, The Second Hospital of Anhui Medical UniversityDepartment of Oncology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Urology, The Second Hospital of Anhui Medical UniversityDepartment of Urology, The Second Hospital of Anhui Medical UniversityDepartment of Urology, The Second Hospital of Anhui Medical UniversityDepartment of Urology, The Second Hospital of Anhui Medical UniversityDepartment of Urology, The Second Hospital of Anhui Medical UniversityAbstract Clear cell renal cell carcinoma is a common malignant tumor of the urinary system. The mechanism of its occurrence and development is unknown, and there is currently few effective comprehensive predictive markers for prognosis and treatment response. With the discovery of a new cell death process – cuproptosis drew the attention of researchers. We constructed a model for the prediction of clinical prognosis and immunotherapy response through integrative analysis of gene expression datasets from KIRC samples in The Cancer Genome Atlas (TCGA) database. During the course of the study, we found that cuproptosis genes are significantly differentially expressed between clear cell renal cell carcinoma samples and normal samples. Based on this, we put forward the prognostic model for cuproptosis gene related-long non-coding RNA. And through various statistic and external independent cohorts, we proved that the model is accurate and stable, worthy of clinical application and further exploration and validation.https://doi.org/10.1186/s12885-022-10278-zRenal clear cell carcinomaCuproptosisLong non-coding RNAPrognosisImmunity therapyBioinformatics engineering |
| spellingShingle | Dian Xia Qi Liu Wen Jiao Longfei Peng Qi Wang ZhouTing Tuo Liangkuan Bi Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study BMC Cancer Renal clear cell carcinoma Cuproptosis Long non-coding RNA Prognosis Immunity therapy Bioinformatics engineering |
| title | Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study |
| title_full | Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study |
| title_fullStr | Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study |
| title_full_unstemmed | Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study |
| title_short | Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study |
| title_sort | exploration of the role of cuproptosis genes and their related long non coding rna in clear cell renal cell carcinoma a comprehensive bioinformatics study |
| topic | Renal clear cell carcinoma Cuproptosis Long non-coding RNA Prognosis Immunity therapy Bioinformatics engineering |
| url | https://doi.org/10.1186/s12885-022-10278-z |
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