Allosteric crosstalk in modular proteins: Function fine-tuning and drug design
Modular proteins are regulatory proteins that carry out more than one function. These proteins upregulate or downregulate a biochemical cascade to establish homeostasis in cells. To switch the function or alter the efficiency (based on cellular needs), these proteins require different facilitators t...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037023003690 |
| _version_ | 1797384081786273792 |
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| author | Suman Abhishek Waghela Deeksha Krishnapura Ranganatha Nethravathi Mehdi D. Davari Eerappa Rajakumara |
| author_facet | Suman Abhishek Waghela Deeksha Krishnapura Ranganatha Nethravathi Mehdi D. Davari Eerappa Rajakumara |
| author_sort | Suman Abhishek |
| collection | DOAJ |
| description | Modular proteins are regulatory proteins that carry out more than one function. These proteins upregulate or downregulate a biochemical cascade to establish homeostasis in cells. To switch the function or alter the efficiency (based on cellular needs), these proteins require different facilitators that bind to a site different from the catalytic (active/orthosteric) site, aka ‘allosteric site’, and fine-tune their function. These facilitators (or effectors) are allosteric modulators. In this Review, we have discussed the allostery, characterized them based on their mechanisms, and discussed how allostery plays an important role in the activity modulation and function fine-tuning of proteins. Recently there is an emergence in the discovery of allosteric drugs. We have also emphasized the role, significance, and future of allostery in therapeutic applications. |
| first_indexed | 2024-03-08T21:30:22Z |
| format | Article |
| id | doaj.art-aa2e57a2c21546c2a6916e321e647e6c |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-03-08T21:30:22Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-aa2e57a2c21546c2a6916e321e647e6c2023-12-21T07:32:18ZengElsevierComputational and Structural Biotechnology Journal2001-03702023-01-012150035015Allosteric crosstalk in modular proteins: Function fine-tuning and drug designSuman Abhishek0Waghela Deeksha1Krishnapura Ranganatha Nethravathi2Mehdi D. Davari3Eerappa Rajakumara4Macromolecular Structural Biology lab, Department of Biotechnology, Indian Institute of Technology Hyderabad, Telangana 502284, India; Corresponding authors.Macromolecular Structural Biology lab, Department of Biotechnology, Indian Institute of Technology Hyderabad, Telangana 502284, IndiaDepartment of Studies and Research in organic chemistry (DOS&R in organic chemistry), Tumkur University, Karnataka 572102, IndiaDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle 06120, Germany; Corresponding authors.Macromolecular Structural Biology lab, Department of Biotechnology, Indian Institute of Technology Hyderabad, Telangana 502284, India; Corresponding authors.Modular proteins are regulatory proteins that carry out more than one function. These proteins upregulate or downregulate a biochemical cascade to establish homeostasis in cells. To switch the function or alter the efficiency (based on cellular needs), these proteins require different facilitators that bind to a site different from the catalytic (active/orthosteric) site, aka ‘allosteric site’, and fine-tune their function. These facilitators (or effectors) are allosteric modulators. In this Review, we have discussed the allostery, characterized them based on their mechanisms, and discussed how allostery plays an important role in the activity modulation and function fine-tuning of proteins. Recently there is an emergence in the discovery of allosteric drugs. We have also emphasized the role, significance, and future of allostery in therapeutic applications.http://www.sciencedirect.com/science/article/pii/S2001037023003690AllosteryMulti-domain proteinsDrug designEnzyme kineticsProtein function regulationTherapeutics |
| spellingShingle | Suman Abhishek Waghela Deeksha Krishnapura Ranganatha Nethravathi Mehdi D. Davari Eerappa Rajakumara Allosteric crosstalk in modular proteins: Function fine-tuning and drug design Computational and Structural Biotechnology Journal Allostery Multi-domain proteins Drug design Enzyme kinetics Protein function regulation Therapeutics |
| title | Allosteric crosstalk in modular proteins: Function fine-tuning and drug design |
| title_full | Allosteric crosstalk in modular proteins: Function fine-tuning and drug design |
| title_fullStr | Allosteric crosstalk in modular proteins: Function fine-tuning and drug design |
| title_full_unstemmed | Allosteric crosstalk in modular proteins: Function fine-tuning and drug design |
| title_short | Allosteric crosstalk in modular proteins: Function fine-tuning and drug design |
| title_sort | allosteric crosstalk in modular proteins function fine tuning and drug design |
| topic | Allostery Multi-domain proteins Drug design Enzyme kinetics Protein function regulation Therapeutics |
| url | http://www.sciencedirect.com/science/article/pii/S2001037023003690 |
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