ANTIBACTERIAL ACTIVITY OF Lactobacillus casei IMV B-7280 IN CASES OF EXPERIMENTAL UROGENITAL STAPHYLOCOCCAL INFE
The aim of work was to determine antibacterial activity of Lactobacillus casei ІМV В-7280 probiotic strain on the experimental urogenital tract infection of mice. The influence of intravaginal and/or per os administration of this strain once per day during 7 days on the microflora of vagina, kidneys...
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2015-08-01
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| Series: | Biotechnologia Acta |
| Subjects: | |
| Online Access: | http://biotechnology.kiev.ua/images/no3_2015/babenspiv_3_2015.pdf |
| _version_ | 1797708470991978496 |
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| author | Babenko L. P. Lazarenko L. M. Demchenko Z. K. Konarbaeva O. A. Veccio G. Lo Spivak M. Ja. |
| author_facet | Babenko L. P. Lazarenko L. M. Demchenko Z. K. Konarbaeva O. A. Veccio G. Lo Spivak M. Ja. |
| author_sort | Babenko L. P. |
| collection | DOAJ |
| description | The aim of work was to determine antibacterial activity of Lactobacillus casei ІМV В-7280 probiotic strain on the experimental urogenital tract infection of mice. The influence of intravaginal and/or per os administration of this strain once per day during 7 days on the microflora of vagina, kidneys and intestinal contents of Staphylococcus aureus 8325-4 infected mice was studied.
It was established, that in cases of experimental staphylococcal infection of urogenital tract L. Casei IMV B-7280 had effective antagonistic activity against S. aureus 8325-4 and opportunistic bacteria. After L. casei IMV B-7280 introduction into infected mice reduction or complete elimination of S. aureus 8325-4 in vagina, kidneys and intestinal contents in different periods of observation was established. Under the influence of L. casei ІМВ В-7280 the number of coliform bacteria, streptococci and staphylococci in the vagina was normalized, and fungal flora — decreased even in comparison with intact mice. Normalization of kidneys microflora was also observed. In the intestinal contents of infected mice trea ted with L. casei IMV B-7280 the number of streptococci did not change, staphylococci number decreased, but the number of fungal and coliform flora remained relatively low during the observation period.
L. casei IMV B-7280 probiotic strain is promising to create immunobiotics with antibacterial action, which can be used for the prevention and treatment of urogenital infections caused by opportunistic microorganisms. |
| first_indexed | 2024-03-12T06:22:11Z |
| format | Article |
| id | doaj.art-aa2ea5d8a17a46a6a3594839dd6691e9 |
| institution | Directory Open Access Journal |
| issn | 2410-7751 2410-776X |
| language | English |
| last_indexed | 2024-03-12T06:22:11Z |
| publishDate | 2015-08-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | Biotechnologia Acta |
| spelling | doaj.art-aa2ea5d8a17a46a6a3594839dd6691e92023-09-03T02:09:39ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryBiotechnologia Acta2410-77512410-776X2015-08-01839510310.15407/biotech8.03.095ANTIBACTERIAL ACTIVITY OF Lactobacillus casei IMV B-7280 IN CASES OF EXPERIMENTAL UROGENITAL STAPHYLOCOCCAL INFEBabenko L. P.0 Lazarenko L. M.1 Demchenko Z. K.2 Konarbaeva O. A.3Veccio G. Lo4Spivak M. Ja.5Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, KyivZabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, KyivZabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, KyivAuezov South Kazakhstan state University, Shymkent, Republic of KazakhstanStucom Centre of the Studies, Barcelona, SpainZabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, KyivThe aim of work was to determine antibacterial activity of Lactobacillus casei ІМV В-7280 probiotic strain on the experimental urogenital tract infection of mice. The influence of intravaginal and/or per os administration of this strain once per day during 7 days on the microflora of vagina, kidneys and intestinal contents of Staphylococcus aureus 8325-4 infected mice was studied. It was established, that in cases of experimental staphylococcal infection of urogenital tract L. Casei IMV B-7280 had effective antagonistic activity against S. aureus 8325-4 and opportunistic bacteria. After L. casei IMV B-7280 introduction into infected mice reduction or complete elimination of S. aureus 8325-4 in vagina, kidneys and intestinal contents in different periods of observation was established. Under the influence of L. casei ІМВ В-7280 the number of coliform bacteria, streptococci and staphylococci in the vagina was normalized, and fungal flora — decreased even in comparison with intact mice. Normalization of kidneys microflora was also observed. In the intestinal contents of infected mice trea ted with L. casei IMV B-7280 the number of streptococci did not change, staphylococci number decreased, but the number of fungal and coliform flora remained relatively low during the observation period. L. casei IMV B-7280 probiotic strain is promising to create immunobiotics with antibacterial action, which can be used for the prevention and treatment of urogenital infections caused by opportunistic microorganisms.http://biotechnology.kiev.ua/images/no3_2015/babenspiv_3_2015.pdfantibacterial activityimmunobioticsLactobacillus caseiStaphylococcus aureus |
| spellingShingle | Babenko L. P. Lazarenko L. M. Demchenko Z. K. Konarbaeva O. A. Veccio G. Lo Spivak M. Ja. ANTIBACTERIAL ACTIVITY OF Lactobacillus casei IMV B-7280 IN CASES OF EXPERIMENTAL UROGENITAL STAPHYLOCOCCAL INFE Biotechnologia Acta antibacterial activity immunobiotics Lactobacillus casei Staphylococcus aureus |
| title | ANTIBACTERIAL ACTIVITY OF Lactobacillus casei IMV B-7280 IN CASES OF EXPERIMENTAL UROGENITAL STAPHYLOCOCCAL INFE |
| title_full | ANTIBACTERIAL ACTIVITY OF Lactobacillus casei IMV B-7280 IN CASES OF EXPERIMENTAL UROGENITAL STAPHYLOCOCCAL INFE |
| title_fullStr | ANTIBACTERIAL ACTIVITY OF Lactobacillus casei IMV B-7280 IN CASES OF EXPERIMENTAL UROGENITAL STAPHYLOCOCCAL INFE |
| title_full_unstemmed | ANTIBACTERIAL ACTIVITY OF Lactobacillus casei IMV B-7280 IN CASES OF EXPERIMENTAL UROGENITAL STAPHYLOCOCCAL INFE |
| title_short | ANTIBACTERIAL ACTIVITY OF Lactobacillus casei IMV B-7280 IN CASES OF EXPERIMENTAL UROGENITAL STAPHYLOCOCCAL INFE |
| title_sort | antibacterial activity of lactobacillus casei imv b 7280 in cases of experimental urogenital staphylococcal infe |
| topic | antibacterial activity immunobiotics Lactobacillus casei Staphylococcus aureus |
| url | http://biotechnology.kiev.ua/images/no3_2015/babenspiv_3_2015.pdf |
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