Comparison of adiposity indices and their association with insulin resistance and β-cell dysfunction in primary prevention for diabetes in Mexican population
Introduction: Impaired adiposity function, Insulin resistance (IR), and β-cell dysfunction predispose to type 2 diabetes (T2D). Some indices, such as the Visceral Adiposity Index (VAI), Dysfunctional Adiposity Index (DAI), and Atherogenic Index of Plasma (AIP), have been developed as surrogates of d...
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Elsevier
2022-10-01
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Series: | Diabetes Epidemiology and Management |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2666970622000415 |
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author | Froylan David Martínez-Sánchez Alejandra Diaz-Jarquin Valerie Paola Vargas-Abonce Jose Luis Torres-Cuevas Anna Paula Guerrero-Castillo David Medina-Julio Clara Elena Meza-Arana Alfonso Gulias-Herrero Miguel Ángel Gómez-Sámano |
author_facet | Froylan David Martínez-Sánchez Alejandra Diaz-Jarquin Valerie Paola Vargas-Abonce Jose Luis Torres-Cuevas Anna Paula Guerrero-Castillo David Medina-Julio Clara Elena Meza-Arana Alfonso Gulias-Herrero Miguel Ángel Gómez-Sámano |
author_sort | Froylan David Martínez-Sánchez |
collection | DOAJ |
description | Introduction: Impaired adiposity function, Insulin resistance (IR), and β-cell dysfunction predispose to type 2 diabetes (T2D). Some indices, such as the Visceral Adiposity Index (VAI), Dysfunctional Adiposity Index (DAI), and Atherogenic Index of Plasma (AIP), have been developed as surrogates of dysfunctional adiposity. However, the association of these indices with IR and β-cell dysfunction in primary prevention for T2D has not been fully studied. Materials and Methods: This was a cross-sectional study that included 401 asymptomatic subjects with at least two risk factors for T2D that underwent an oral glucose tolerance test. A HOMA-IR ≥2.5 and a Disposition Index ≤1.24 were used to define IR and β-cell dysfunction, respectively. Results: Mean age of the subjects was 50.4 ± 9.6 years, 71.6% were women, had a mean BMI of 30.3 ± 6.4 kg/m2 27.6% and 11.6% had newly diagnosed T2D. After multiple regression analysis the VAI, DAI, and AIP were associated with IR (1.218 [1.103–1.345], 1.355 [1.150–1.597], and 2.533 [1.733–3.703], respectively), and β-cell dysfunction (1.119 [1.029–1.217], 1.193 [1.034–1.376], and 1.960 [1.357–2.830], respectively). Likewise, the AIP was the only index associated for newly T2D diagnosis (1.974 [1.224–3.184]). Conclusions: The VAI, DAI and AIP were independently associated with IR and β-cell dysfunction in patients at high risk for T2D. |
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institution | Directory Open Access Journal |
issn | 2666-9706 |
language | English |
last_indexed | 2024-04-12T08:00:02Z |
publishDate | 2022-10-01 |
publisher | Elsevier |
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series | Diabetes Epidemiology and Management |
spelling | doaj.art-aa2f29da24dc445e806e827f93738c752022-12-22T03:41:20ZengElsevierDiabetes Epidemiology and Management2666-97062022-10-018100091Comparison of adiposity indices and their association with insulin resistance and β-cell dysfunction in primary prevention for diabetes in Mexican populationFroylan David Martínez-Sánchez0Alejandra Diaz-Jarquin1Valerie Paola Vargas-Abonce2Jose Luis Torres-Cuevas3Anna Paula Guerrero-Castillo4David Medina-Julio5Clara Elena Meza-Arana6Alfonso Gulias-Herrero7Miguel Ángel Gómez-Sámano8Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Vasco de Quiroga # 15, Belisario Domínguez Sección XVI,Tlalpan', Mexico City 14080, Mexico; Facultad de Ciencias de la Salud, Universidad Anáhuac México Norte, Av. Universidad Anáhuac #46. Lomas Anáhuac, Huixquilucan, Estado de Mexico 52786, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Vasco de Quiroga # 15, Belisario Domínguez Sección XVI,Tlalpan', Mexico City 14080, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Vasco de Quiroga # 15, Belisario Domínguez Sección XVI,Tlalpan', Mexico City 14080, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Vasco de Quiroga # 15, Belisario Domínguez Sección XVI,Tlalpan', Mexico City 14080, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Vasco de Quiroga # 15, Belisario Domínguez Sección XVI,Tlalpan', Mexico City 14080, Mexico; Facultad de Ciencias de la Salud, Universidad Anáhuac México Norte, Av. Universidad Anáhuac #46. Lomas Anáhuac, Huixquilucan, Estado de Mexico 52786, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Vasco de Quiroga # 15, Belisario Domínguez Sección XVI,Tlalpan', Mexico City 14080, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Vasco de Quiroga # 15, Belisario Domínguez Sección XVI,Tlalpan', Mexico City 14080, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Vasco de Quiroga # 15, Belisario Domínguez Sección XVI,Tlalpan', Mexico City 14080, MexicoDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Vasco de Quiroga # 15, Belisario Domínguez Sección XVI,Tlalpan', Mexico City 14080, Mexico; Corresponding author.Introduction: Impaired adiposity function, Insulin resistance (IR), and β-cell dysfunction predispose to type 2 diabetes (T2D). Some indices, such as the Visceral Adiposity Index (VAI), Dysfunctional Adiposity Index (DAI), and Atherogenic Index of Plasma (AIP), have been developed as surrogates of dysfunctional adiposity. However, the association of these indices with IR and β-cell dysfunction in primary prevention for T2D has not been fully studied. Materials and Methods: This was a cross-sectional study that included 401 asymptomatic subjects with at least two risk factors for T2D that underwent an oral glucose tolerance test. A HOMA-IR ≥2.5 and a Disposition Index ≤1.24 were used to define IR and β-cell dysfunction, respectively. Results: Mean age of the subjects was 50.4 ± 9.6 years, 71.6% were women, had a mean BMI of 30.3 ± 6.4 kg/m2 27.6% and 11.6% had newly diagnosed T2D. After multiple regression analysis the VAI, DAI, and AIP were associated with IR (1.218 [1.103–1.345], 1.355 [1.150–1.597], and 2.533 [1.733–3.703], respectively), and β-cell dysfunction (1.119 [1.029–1.217], 1.193 [1.034–1.376], and 1.960 [1.357–2.830], respectively). Likewise, the AIP was the only index associated for newly T2D diagnosis (1.974 [1.224–3.184]). Conclusions: The VAI, DAI and AIP were independently associated with IR and β-cell dysfunction in patients at high risk for T2D.http://www.sciencedirect.com/science/article/pii/S2666970622000415Type 2 diabetesInsulin resistanceβ-cell dysfunctionFunctional adipose tissue |
spellingShingle | Froylan David Martínez-Sánchez Alejandra Diaz-Jarquin Valerie Paola Vargas-Abonce Jose Luis Torres-Cuevas Anna Paula Guerrero-Castillo David Medina-Julio Clara Elena Meza-Arana Alfonso Gulias-Herrero Miguel Ángel Gómez-Sámano Comparison of adiposity indices and their association with insulin resistance and β-cell dysfunction in primary prevention for diabetes in Mexican population Diabetes Epidemiology and Management Type 2 diabetes Insulin resistance β-cell dysfunction Functional adipose tissue |
title | Comparison of adiposity indices and their association with insulin resistance and β-cell dysfunction in primary prevention for diabetes in Mexican population |
title_full | Comparison of adiposity indices and their association with insulin resistance and β-cell dysfunction in primary prevention for diabetes in Mexican population |
title_fullStr | Comparison of adiposity indices and their association with insulin resistance and β-cell dysfunction in primary prevention for diabetes in Mexican population |
title_full_unstemmed | Comparison of adiposity indices and their association with insulin resistance and β-cell dysfunction in primary prevention for diabetes in Mexican population |
title_short | Comparison of adiposity indices and their association with insulin resistance and β-cell dysfunction in primary prevention for diabetes in Mexican population |
title_sort | comparison of adiposity indices and their association with insulin resistance and β cell dysfunction in primary prevention for diabetes in mexican population |
topic | Type 2 diabetes Insulin resistance β-cell dysfunction Functional adipose tissue |
url | http://www.sciencedirect.com/science/article/pii/S2666970622000415 |
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