Interactions Under Crowding Milieu: Chemical-Induced Denaturation of Myoglobin is Determined by the Extent of Heme Dissociation on Interaction with Crowders

Interactions Under Crowding Milieu: Chemical-Induced Denaturation of Myoglobin is Determined by the Extent of Heme Dissociation on Interaction with Crowders

Generally, in vivo function and structural changes are studied by probing proteins in a dilute solution under in vitro conditions, which is believed to be mimicking proteins in intracellular milieu. Earlier, thermal-induced denaturation of myoglobin, in the milieu of crowder molecule showed destabil...

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Bibliographic Details
Main Authors: Khalida Nasreen, Zahoor Ahmad Parray, Shahzaib Ahamad, Faizan Ahmad, Anwar Ahmed, Salman Freeh Alamery, Tajamul Hussain, Md. Imtaiyaz Hassan, Asimul Islam
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomolecules
Subjects:
macromolecular crowding
protein stability
chemical-induced denaturation
myoglobin
binding-induced folding
isothermal titration calorimetry
Online Access:https://www.mdpi.com/2218-273X/10/3/490

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