Characterizing the microbiota of cleft lip and palate patients: a comprehensive review
Orofacial cleft disorders, including cleft lip and/or palate (CL/P), are one of the most frequently-occurring congenital disorders worldwide. The health issues of patients with CL/P encompass far more than just their anatomic anomaly, as patients with CL/P are prone to having a high incidence of inf...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1159455/full |
| _version_ | 1797844754062376960 |
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| author | Elizabeth Gershater Yuan Liu Yuan Liu Binglan Xue Min Kyung Shin Hyun Koo Hyun Koo Zhong Zheng Chenshuang Li |
| author_facet | Elizabeth Gershater Yuan Liu Yuan Liu Binglan Xue Min Kyung Shin Hyun Koo Hyun Koo Zhong Zheng Chenshuang Li |
| author_sort | Elizabeth Gershater |
| collection | DOAJ |
| description | Orofacial cleft disorders, including cleft lip and/or palate (CL/P), are one of the most frequently-occurring congenital disorders worldwide. The health issues of patients with CL/P encompass far more than just their anatomic anomaly, as patients with CL/P are prone to having a high incidence of infectious diseases. While it has been previously established that the oral microbiome of patients with CL/P differs from that of unaffected patients, the exact nature of this variance, including the relevant bacterial species, has not been fully elucidated; likewise, examination of anatomic locations besides the cleft site has been neglected. Here, we intended to provide a comprehensive review to highlight the significant microbiota differences between CL/P patients and healthy subjects in various anatomic locations, including the teeth inside and adjacent to the cleft, oral cavity, nasal cavity, pharynx, and ear, as well as bodily fluids, secretions, and excretions. A number of bacterial and fungal species that have been proven to be pathogenic were found to be prevalently and/or specifically detected in CL/P patients, which can benefit the development of CL/P-specific microbiota management strategies. |
| first_indexed | 2024-04-09T17:27:23Z |
| format | Article |
| id | doaj.art-aa33c8b3ee204c2a886ce6f61c43d95a |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-09T17:27:23Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-aa33c8b3ee204c2a886ce6f61c43d95a2023-04-18T10:13:26ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-04-011310.3389/fcimb.2023.11594551159455Characterizing the microbiota of cleft lip and palate patients: a comprehensive reviewElizabeth Gershater0Yuan Liu1Yuan Liu2Binglan Xue3Min Kyung Shin4Hyun Koo5Hyun Koo6Zhong Zheng7Chenshuang Li8Department of Biology, Muhlenberg College, Allentown, PA, United StatesBiofilm Research Laboratories, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United StatesDepartment of Preventive and Restorative Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United StatesSchool of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United StatesDepartment of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United StatesBiofilm Research Laboratories, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United StatesCenter for Innovation & Precision Dentistry, School of Dental Medicine and School of Engineering & Applied Sciences, University of Pennsylvania, Philadelphia, PA, United StatesDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United StatesOrofacial cleft disorders, including cleft lip and/or palate (CL/P), are one of the most frequently-occurring congenital disorders worldwide. The health issues of patients with CL/P encompass far more than just their anatomic anomaly, as patients with CL/P are prone to having a high incidence of infectious diseases. While it has been previously established that the oral microbiome of patients with CL/P differs from that of unaffected patients, the exact nature of this variance, including the relevant bacterial species, has not been fully elucidated; likewise, examination of anatomic locations besides the cleft site has been neglected. Here, we intended to provide a comprehensive review to highlight the significant microbiota differences between CL/P patients and healthy subjects in various anatomic locations, including the teeth inside and adjacent to the cleft, oral cavity, nasal cavity, pharynx, and ear, as well as bodily fluids, secretions, and excretions. A number of bacterial and fungal species that have been proven to be pathogenic were found to be prevalently and/or specifically detected in CL/P patients, which can benefit the development of CL/P-specific microbiota management strategies.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1159455/fullcleft lipcleft palatebiofilmoral microbiomebacteriafungus |
| spellingShingle | Elizabeth Gershater Yuan Liu Yuan Liu Binglan Xue Min Kyung Shin Hyun Koo Hyun Koo Zhong Zheng Chenshuang Li Characterizing the microbiota of cleft lip and palate patients: a comprehensive review Frontiers in Cellular and Infection Microbiology cleft lip cleft palate biofilm oral microbiome bacteria fungus |
| title | Characterizing the microbiota of cleft lip and palate patients: a comprehensive review |
| title_full | Characterizing the microbiota of cleft lip and palate patients: a comprehensive review |
| title_fullStr | Characterizing the microbiota of cleft lip and palate patients: a comprehensive review |
| title_full_unstemmed | Characterizing the microbiota of cleft lip and palate patients: a comprehensive review |
| title_short | Characterizing the microbiota of cleft lip and palate patients: a comprehensive review |
| title_sort | characterizing the microbiota of cleft lip and palate patients a comprehensive review |
| topic | cleft lip cleft palate biofilm oral microbiome bacteria fungus |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1159455/full |
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