STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1
BRCA1, a multi-domain protein, is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 is most often mutated in three domains or regions: the N-terminal RING domain, exons 11–13, and the BRCT domain. The BRCA1 RING domain is responsible for the E3 ubiquitin ligase activity o...
| Hlavní autoři: | , , , , |
|---|---|
| Médium: | Článek |
| Jazyk: | English |
| Vydáno: |
Elsevier
2012-04-01
|
| Edice: | Computational and Structural Biotechnology Journal |
| Témata: | |
| On-line přístup: | http://www.sciencedirect.com/science/article/pii/S2001037014601070 |