Autoimmune thyroid disease disrupts immune homeostasis in the endometrium of unexplained infertility women—a single-cell RNA transcriptome study during the implantation window

Autoimmune thyroid disease disrupts immune homeostasis in the endometrium of unexplained infertility women—a single-cell RNA transcriptome study during the implantation window

ObjectiveAutoimmune thyroid disease (AITD) is known to be associated with unexplained infertility in women. Although the presence of antithyroid antibodies have been speculated to be a marker of an immune imbalance that might lead to implantation failure, its underlying mechanism influencing the end...

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Bibliographic Details
Main Authors: Jilai Xie, Aiyuan Gu, Huangyi He, Qiaohang Zhao, Ya Yu, Jian Chen, Zhangliang Cheng, Ping Zhou, Qi Zhou, Min Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Endocrinology
Subjects:
autoimmune thyroid disease
unexplained infertility
endometrial receptivity
window of implantation
single-cell RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1185147/full

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