Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates
Abstract Prematurity predisposes to cardiovascular disease; however the underlying mechanisms remain elusive. Disturbance of the endothelial glycocalyx (EG), an important regulator of vessel function, is thought to contribute to vascular pathology. Here, we studied the EG with respect to gestational...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-81847-8 |
| _version_ | 1818420569311281152 |
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| author | Alexandra Puchwein-Schwepcke Stefanie Artmann Lea Rajwich Orsolya Genzel-Boroviczény Claudia Nussbaum |
| author_facet | Alexandra Puchwein-Schwepcke Stefanie Artmann Lea Rajwich Orsolya Genzel-Boroviczény Claudia Nussbaum |
| author_sort | Alexandra Puchwein-Schwepcke |
| collection | DOAJ |
| description | Abstract Prematurity predisposes to cardiovascular disease; however the underlying mechanisms remain elusive. Disturbance of the endothelial glycocalyx (EG), an important regulator of vessel function, is thought to contribute to vascular pathology. Here, we studied the EG with respect to gestational and postnatal age in preterm and term neonates. The Perfused Boundary Region (PBR), an inverse measure of glycocalyx thickness, was measured postnatally in 85 term and 39 preterm neonates. Preterm neonates were further analyzed in two subgroups i.e., neonates born < 30 weeks gestational age (group A) and neonates born ≥ 30 weeks (group B). In preterm neonates, weekly follow-up measurements were performed if possible. PBR differed significantly between preterm and term neonates with lowest values representing largest EG dimension in extremely premature infants possibly reflecting its importance in fetal vascular development. Linear regression revealed a dependence of PBR on both, gestational age and postnatal age. Furthermore, hematocrit predicted longitudinal PBR changes. PBR measured in group A at a corrected age of > 30 weeks was significantly higher than in group B at birth, pointing towards an alteration of intrinsic maturational effects by extrinsic factors. These changes might contribute to the increased cardiovascular risk associated with extreme prematurity. |
| first_indexed | 2024-12-14T12:56:33Z |
| format | Article |
| id | doaj.art-aa38f59c8ec54480a7c98bfeac25b48f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T12:56:33Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-aa38f59c8ec54480a7c98bfeac25b48f2022-12-21T23:00:34ZengNature PortfolioScientific Reports2045-23222021-02-0111111010.1038/s41598-021-81847-8Effect of gestational age and postnatal age on the endothelial glycocalyx in neonatesAlexandra Puchwein-Schwepcke0Stefanie Artmann1Lea Rajwich2Orsolya Genzel-Boroviczény3Claudia Nussbaum4Division of Neonatology, Dr. von Hauner Children’s Hospital, University Hospital, LMU MunichDivision of Neonatology, Dr. von Hauner Children’s Hospital, University Hospital, LMU MunichDivision of Neonatology, Dr. von Hauner Children’s Hospital, University Hospital, LMU MunichDivision of Neonatology, Dr. von Hauner Children’s Hospital, University Hospital, LMU MunichDivision of Neonatology, Dr. von Hauner Children’s Hospital, University Hospital, LMU MunichAbstract Prematurity predisposes to cardiovascular disease; however the underlying mechanisms remain elusive. Disturbance of the endothelial glycocalyx (EG), an important regulator of vessel function, is thought to contribute to vascular pathology. Here, we studied the EG with respect to gestational and postnatal age in preterm and term neonates. The Perfused Boundary Region (PBR), an inverse measure of glycocalyx thickness, was measured postnatally in 85 term and 39 preterm neonates. Preterm neonates were further analyzed in two subgroups i.e., neonates born < 30 weeks gestational age (group A) and neonates born ≥ 30 weeks (group B). In preterm neonates, weekly follow-up measurements were performed if possible. PBR differed significantly between preterm and term neonates with lowest values representing largest EG dimension in extremely premature infants possibly reflecting its importance in fetal vascular development. Linear regression revealed a dependence of PBR on both, gestational age and postnatal age. Furthermore, hematocrit predicted longitudinal PBR changes. PBR measured in group A at a corrected age of > 30 weeks was significantly higher than in group B at birth, pointing towards an alteration of intrinsic maturational effects by extrinsic factors. These changes might contribute to the increased cardiovascular risk associated with extreme prematurity.https://doi.org/10.1038/s41598-021-81847-8 |
| spellingShingle | Alexandra Puchwein-Schwepcke Stefanie Artmann Lea Rajwich Orsolya Genzel-Boroviczény Claudia Nussbaum Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates Scientific Reports |
| title | Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates |
| title_full | Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates |
| title_fullStr | Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates |
| title_full_unstemmed | Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates |
| title_short | Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates |
| title_sort | effect of gestational age and postnatal age on the endothelial glycocalyx in neonates |
| url | https://doi.org/10.1038/s41598-021-81847-8 |
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