Evaluation of serum urea, uric acid and creatinine in OSMF patients: A clinical and biochemical stusdy
Introduction: Oral submucous fibrosis (OSMF) is described as a chronic debilitating disease of the submucosal tissue. Leaching out compounds from areca nut is the main etiology for OSMF. Biochemical examinations have concentrated on demarcating changes in the blood, serum, or tissues of patients wit...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Indian Academy of Oral Medicine and Radiology |
| Subjects: | |
| Online Access: | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2022;volume=34;issue=3;spage=272;epage=275;aulast=Verma |
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| author | Swati Verma Rahul R Bhowate |
| author_facet | Swati Verma Rahul R Bhowate |
| author_sort | Swati Verma |
| collection | DOAJ |
| description | Introduction: Oral submucous fibrosis (OSMF) is described as a chronic debilitating disease of the submucosal tissue. Leaching out compounds from areca nut is the main etiology for OSMF. Biochemical examinations have concentrated on demarcating changes in the blood, serum, or tissues of patients with this disease. Such examinations have given insights into the possible pathogenesis of OSMF. Aim: Estimation of serum urea, uric acid (UA), and creatinine (Cn.) in OSMF patients. Objective: To estimate the level of serum urea, UA, and Cn. in OSMF patients and compare them with habitual betel nut chewers. Materials and Methods: The purposive samples were selected from patients attending the OPD of the Oral Medicine and Radiology (OMR) Department. In total 180 patients were included and divided into three groups. Group I-Patients suffering from OSMF, Group II-Habitual control, and Group III-Healthy control. Results: The mean value of serum UA (mg/dL) in Group I was 7.82 ± 2.18, Group II was 5.83 ± 1.22, and Group III was 5.28 ± 1.10. The mean value of serum Cn. (mg/dL) in Group I was 1.05 ± 0.27, Group II was 1.15 ± 0.22, and Group III was 0.72 ± 0.21. One-way analysis of variance (ANOVA) was applied between the groups and significant differences were found for both serum UA and Cn. with P < 0.0001, whereas no significant difference was found for serum urea. Conclusion: It can be concluded from this study that serum urea, UA, and Cn. of OSMF patients should be evaluated for liver and renal involvement and for overall improving the disease prognosis. |
| first_indexed | 2024-04-12T13:25:26Z |
| format | Article |
| id | doaj.art-aa3c2980739942e0aa5cc5f08ba8efe4 |
| institution | Directory Open Access Journal |
| issn | 0972-1363 |
| language | English |
| last_indexed | 2024-04-12T13:25:26Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Academy of Oral Medicine and Radiology |
| spelling | doaj.art-aa3c2980739942e0aa5cc5f08ba8efe42022-12-22T03:31:21ZengWolters Kluwer Medknow PublicationsJournal of Indian Academy of Oral Medicine and Radiology0972-13632022-01-0134327227510.4103/jiaomr.jiaomr_151_21Evaluation of serum urea, uric acid and creatinine in OSMF patients: A clinical and biochemical stusdySwati VermaRahul R BhowateIntroduction: Oral submucous fibrosis (OSMF) is described as a chronic debilitating disease of the submucosal tissue. Leaching out compounds from areca nut is the main etiology for OSMF. Biochemical examinations have concentrated on demarcating changes in the blood, serum, or tissues of patients with this disease. Such examinations have given insights into the possible pathogenesis of OSMF. Aim: Estimation of serum urea, uric acid (UA), and creatinine (Cn.) in OSMF patients. Objective: To estimate the level of serum urea, UA, and Cn. in OSMF patients and compare them with habitual betel nut chewers. Materials and Methods: The purposive samples were selected from patients attending the OPD of the Oral Medicine and Radiology (OMR) Department. In total 180 patients were included and divided into three groups. Group I-Patients suffering from OSMF, Group II-Habitual control, and Group III-Healthy control. Results: The mean value of serum UA (mg/dL) in Group I was 7.82 ± 2.18, Group II was 5.83 ± 1.22, and Group III was 5.28 ± 1.10. The mean value of serum Cn. (mg/dL) in Group I was 1.05 ± 0.27, Group II was 1.15 ± 0.22, and Group III was 0.72 ± 0.21. One-way analysis of variance (ANOVA) was applied between the groups and significant differences were found for both serum UA and Cn. with P < 0.0001, whereas no significant difference was found for serum urea. Conclusion: It can be concluded from this study that serum urea, UA, and Cn. of OSMF patients should be evaluated for liver and renal involvement and for overall improving the disease prognosis.http://www.jiaomr.in/article.asp?issn=0972-1363;year=2022;volume=34;issue=3;spage=272;epage=275;aulast=Vermacnosmfuaureakey message: areca nut habit is associated with multiple systemic disorders because of areca nut alkaloids. one should always check for systemic involvement in osmf and betel nut chewerswhich will help in treatment modality. |
| spellingShingle | Swati Verma Rahul R Bhowate Evaluation of serum urea, uric acid and creatinine in OSMF patients: A clinical and biochemical stusdy Journal of Indian Academy of Oral Medicine and Radiology cn osmf ua ureakey message: areca nut habit is associated with multiple systemic disorders because of areca nut alkaloids. one should always check for systemic involvement in osmf and betel nut chewers which will help in treatment modality. |
| title | Evaluation of serum urea, uric acid and creatinine in OSMF patients: A clinical and biochemical stusdy |
| title_full | Evaluation of serum urea, uric acid and creatinine in OSMF patients: A clinical and biochemical stusdy |
| title_fullStr | Evaluation of serum urea, uric acid and creatinine in OSMF patients: A clinical and biochemical stusdy |
| title_full_unstemmed | Evaluation of serum urea, uric acid and creatinine in OSMF patients: A clinical and biochemical stusdy |
| title_short | Evaluation of serum urea, uric acid and creatinine in OSMF patients: A clinical and biochemical stusdy |
| title_sort | evaluation of serum urea uric acid and creatinine in osmf patients a clinical and biochemical stusdy |
| topic | cn osmf ua ureakey message: areca nut habit is associated with multiple systemic disorders because of areca nut alkaloids. one should always check for systemic involvement in osmf and betel nut chewers which will help in treatment modality. |
| url | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2022;volume=34;issue=3;spage=272;epage=275;aulast=Verma |
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