Association of circadian rhythm with mild cognitive impairment among male pneumoconiosis workers in Hong Kong: a cross-sectional study
Abstract Weakened circadian activity rhythms (CARs) were associated with mild cognitive impairment (MCI) in the general population. However, it remains unclear among pneumoconiosis patients. We aimed to address this knowledge gap. This cross-sectional study comprised 186 male pneumoconiosis patients...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-28832-5 |
| _version_ | 1811171777109295104 |
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| author | Bixia Huang Gengze Liao Priscilla Ming Yi Lee Chi Kuen Chan Lai-bun Tai Chun Yuk Jason Tsang Chi Chiu Leung Lap Ah Tse |
| author_facet | Bixia Huang Gengze Liao Priscilla Ming Yi Lee Chi Kuen Chan Lai-bun Tai Chun Yuk Jason Tsang Chi Chiu Leung Lap Ah Tse |
| author_sort | Bixia Huang |
| collection | DOAJ |
| description | Abstract Weakened circadian activity rhythms (CARs) were associated with mild cognitive impairment (MCI) in the general population. However, it remains unclear among pneumoconiosis patients. We aimed to address this knowledge gap. This cross-sectional study comprised 186 male pneumoconiosis patients (71.3 ± 7.8 years) and 208 healthy community men. Actigraphy was used to determine CARs parameters (percent rhythm, amplitude, MESOR, and acrophase). Values below the corresponding medians of the CARs parameters represented weakened CARs. The Cantonese version of Mini-Mental State Examination (CMMSE) was used to assess cognitive function, MCI, and the composite outcome of MCI plus cognitive impairment. Compared with the community referents, pneumoconiosis patients had worse cognition and dampened CARs. Compared with the community referents or pneumoconiosis patients with robust circadian rhythm, pneumoconiosis patients with weakened circadian rhythm were consistently associated with increased risk of MCI and the composite outcome. However, significant association was only observed between MESOR and the composite outcome (adjusted OR = 1.99, 95%: 1.04–3.81). A delayed phase of CARs was insignificantly associated with MCI and the composite outcome. Our findings showed that weakened CARs were associated with worse cognitive function among male pneumoconiosis workers. Intervention in improving CARs may mitigate cognitive deterioration in male pneumoconiosis workers. |
| first_indexed | 2024-04-10T17:19:42Z |
| format | Article |
| id | doaj.art-aa3d5a7b87ec4676a97d723ebbae36f7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T17:19:42Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-aa3d5a7b87ec4676a97d723ebbae36f72023-02-05T12:09:21ZengNature PortfolioScientific Reports2045-23222023-01-0113111010.1038/s41598-023-28832-5Association of circadian rhythm with mild cognitive impairment among male pneumoconiosis workers in Hong Kong: a cross-sectional studyBixia Huang0Gengze Liao1Priscilla Ming Yi Lee2Chi Kuen Chan3Lai-bun Tai4Chun Yuk Jason Tsang5Chi Chiu Leung6Lap Ah Tse7JC School of Public Health and Primary Care, The Chinese University of Hong KongJC School of Public Health and Primary Care, The Chinese University of Hong KongJC School of Public Health and Primary Care, The Chinese University of Hong KongPneumoconiosis Clinic, Tuberculosis and Chest Service, Department of HealthPneumoconiosis Clinic, Tuberculosis and Chest Service, Department of HealthPneumoconiosis Mutual Aid AssociationStanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong KongJC School of Public Health and Primary Care, The Chinese University of Hong KongAbstract Weakened circadian activity rhythms (CARs) were associated with mild cognitive impairment (MCI) in the general population. However, it remains unclear among pneumoconiosis patients. We aimed to address this knowledge gap. This cross-sectional study comprised 186 male pneumoconiosis patients (71.3 ± 7.8 years) and 208 healthy community men. Actigraphy was used to determine CARs parameters (percent rhythm, amplitude, MESOR, and acrophase). Values below the corresponding medians of the CARs parameters represented weakened CARs. The Cantonese version of Mini-Mental State Examination (CMMSE) was used to assess cognitive function, MCI, and the composite outcome of MCI plus cognitive impairment. Compared with the community referents, pneumoconiosis patients had worse cognition and dampened CARs. Compared with the community referents or pneumoconiosis patients with robust circadian rhythm, pneumoconiosis patients with weakened circadian rhythm were consistently associated with increased risk of MCI and the composite outcome. However, significant association was only observed between MESOR and the composite outcome (adjusted OR = 1.99, 95%: 1.04–3.81). A delayed phase of CARs was insignificantly associated with MCI and the composite outcome. Our findings showed that weakened CARs were associated with worse cognitive function among male pneumoconiosis workers. Intervention in improving CARs may mitigate cognitive deterioration in male pneumoconiosis workers.https://doi.org/10.1038/s41598-023-28832-5 |
| spellingShingle | Bixia Huang Gengze Liao Priscilla Ming Yi Lee Chi Kuen Chan Lai-bun Tai Chun Yuk Jason Tsang Chi Chiu Leung Lap Ah Tse Association of circadian rhythm with mild cognitive impairment among male pneumoconiosis workers in Hong Kong: a cross-sectional study Scientific Reports |
| title | Association of circadian rhythm with mild cognitive impairment among male pneumoconiosis workers in Hong Kong: a cross-sectional study |
| title_full | Association of circadian rhythm with mild cognitive impairment among male pneumoconiosis workers in Hong Kong: a cross-sectional study |
| title_fullStr | Association of circadian rhythm with mild cognitive impairment among male pneumoconiosis workers in Hong Kong: a cross-sectional study |
| title_full_unstemmed | Association of circadian rhythm with mild cognitive impairment among male pneumoconiosis workers in Hong Kong: a cross-sectional study |
| title_short | Association of circadian rhythm with mild cognitive impairment among male pneumoconiosis workers in Hong Kong: a cross-sectional study |
| title_sort | association of circadian rhythm with mild cognitive impairment among male pneumoconiosis workers in hong kong a cross sectional study |
| url | https://doi.org/10.1038/s41598-023-28832-5 |
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