Quetiapine inhibits microglial activation by neutralizing abnormal STIM1 mediated intercellular calcium homeostasis and promotes myelin repair in a cuprizone -induced mouse model of de-myelination

Quetiapine inhibits microglial activation by neutralizing abnormal STIM1 mediated intercellular calcium homeostasis and promotes myelin repair in a cuprizone -induced mouse model of de-myelination

Microglial activation has been considered as a crucial process in the pathogenesis of neuro-inflammation and psychiatric disorders. Several antipsychotic drugs have been shown to display inhibitory effects on microglial activation in vitro, possibly through the suppression of elevated intracellular...

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Bibliographic Details
Main Authors: Hanzhi eWang, Shubao eLiu, Yanping eTian, Xiyan eWu, Chengren eLi, Yangtao eHe, Michael eNamaka, Jiming eKong, Hongli eLi, Lan eXiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
calcium homeostasis
microglial activation
quetiapine
STIM1
store-operated calcium entry
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00492/full

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