Innovative drugs, chemicals, and enzymes within the animal production chain
Abstract The alarming number of recently reported human illnesses with bacterial infections resistant to multiple antibacterial agents has become a serious concern in recent years. This phenomenon is a core challenge for both the medical and animal health communities, since the use of antibiotics ha...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | Veterinary Research |
| Online Access: | http://link.springer.com/article/10.1186/s13567-018-0559-1 |
| _version_ | 1811237953593147392 |
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| author | Yousef I. Hassan Ludovic Lahaye Max M. Gong Jian Peng Joshua Gong Song Liu Cyril G. Gay Chengbo Yang |
| author_facet | Yousef I. Hassan Ludovic Lahaye Max M. Gong Jian Peng Joshua Gong Song Liu Cyril G. Gay Chengbo Yang |
| author_sort | Yousef I. Hassan |
| collection | DOAJ |
| description | Abstract The alarming number of recently reported human illnesses with bacterial infections resistant to multiple antibacterial agents has become a serious concern in recent years. This phenomenon is a core challenge for both the medical and animal health communities, since the use of antibiotics has formed the cornerstone of modern medicine for treating bacterial infections. The empirical benefits of using antibiotics to address animal health issues in animal agriculture (using therapeutic doses) and increasing the overall productivity of animals (using sub-therapeutic doses) are well established. The use of antibiotics to enhance profitability margins in the animal production industry is still practiced worldwide. Although many technical and economic reasons gave rise to these practices, the continued emergence of antimicrobial resistant bacteria is furthering the need to reduce the use of medically important antibiotics. This will require improving on-farm management and biosecurity practices, and the development of effective antibiotic alternatives that will reduce the dependence on antibiotics within the animal industry in the foreseeable future. A number of approaches are being closely scrutinized and optimized to achieve this goal, including the development of promising antibiotic alternatives to control bacterial virulence through quorum-sensing disruption, the use of synthetic polymers and nanoparticles, the exploitation of recombinant enzymes/proteins (such as glucose oxidases, alkaline phosphatases and proteases), and the use of phytochemicals. This review explores the most recent approaches within this context and provides a summary of practical mitigation strategies for the extensive use of antibiotics within the animal production chain in addition to several future challenges that need to be addressed. |
| first_indexed | 2024-04-12T12:32:17Z |
| format | Article |
| id | doaj.art-aa3dae58639648e9bd743d0a5b80d692 |
| institution | Directory Open Access Journal |
| issn | 1297-9716 |
| language | English |
| last_indexed | 2024-04-12T12:32:17Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Veterinary Research |
| spelling | doaj.art-aa3dae58639648e9bd743d0a5b80d6922022-12-22T03:32:59ZengBMCVeterinary Research1297-97162018-07-0149111710.1186/s13567-018-0559-1Innovative drugs, chemicals, and enzymes within the animal production chainYousef I. Hassan0Ludovic Lahaye1Max M. Gong2Jian Peng3Joshua Gong4Song Liu5Cyril G. Gay6Chengbo Yang7Guelph Research and Development Centre, Agriculture and Agri-Food CanadaJefo Nutrition Inc.Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-MadisonCollege of Animal Science, Huazhong Agricultural UniversityGuelph Research and Development Centre, Agriculture and Agri-Food CanadaDepartment of Biosystems Engineering, University of ManitobaOffice of National Programs, Animal Production and Protection, Agricultural Research Service, US Department of AgricultureDepartment of Animal Science, University of ManitobaAbstract The alarming number of recently reported human illnesses with bacterial infections resistant to multiple antibacterial agents has become a serious concern in recent years. This phenomenon is a core challenge for both the medical and animal health communities, since the use of antibiotics has formed the cornerstone of modern medicine for treating bacterial infections. The empirical benefits of using antibiotics to address animal health issues in animal agriculture (using therapeutic doses) and increasing the overall productivity of animals (using sub-therapeutic doses) are well established. The use of antibiotics to enhance profitability margins in the animal production industry is still practiced worldwide. Although many technical and economic reasons gave rise to these practices, the continued emergence of antimicrobial resistant bacteria is furthering the need to reduce the use of medically important antibiotics. This will require improving on-farm management and biosecurity practices, and the development of effective antibiotic alternatives that will reduce the dependence on antibiotics within the animal industry in the foreseeable future. A number of approaches are being closely scrutinized and optimized to achieve this goal, including the development of promising antibiotic alternatives to control bacterial virulence through quorum-sensing disruption, the use of synthetic polymers and nanoparticles, the exploitation of recombinant enzymes/proteins (such as glucose oxidases, alkaline phosphatases and proteases), and the use of phytochemicals. This review explores the most recent approaches within this context and provides a summary of practical mitigation strategies for the extensive use of antibiotics within the animal production chain in addition to several future challenges that need to be addressed.http://link.springer.com/article/10.1186/s13567-018-0559-1 |
| spellingShingle | Yousef I. Hassan Ludovic Lahaye Max M. Gong Jian Peng Joshua Gong Song Liu Cyril G. Gay Chengbo Yang Innovative drugs, chemicals, and enzymes within the animal production chain Veterinary Research |
| title | Innovative drugs, chemicals, and enzymes within the animal production chain |
| title_full | Innovative drugs, chemicals, and enzymes within the animal production chain |
| title_fullStr | Innovative drugs, chemicals, and enzymes within the animal production chain |
| title_full_unstemmed | Innovative drugs, chemicals, and enzymes within the animal production chain |
| title_short | Innovative drugs, chemicals, and enzymes within the animal production chain |
| title_sort | innovative drugs chemicals and enzymes within the animal production chain |
| url | http://link.springer.com/article/10.1186/s13567-018-0559-1 |
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