52-year follow-up of a birth cohort reveals a high pneumonia incidence among young men
Background Knowledge of pneumonia incidence and risk factors in adults is mainly based on clinical studies of selected patient data and registers with ageing populations. Prospective population-based investigations, such as birth cohort studies, are needed to understand pneumonia incidence and risk...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2022-06-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/8/2/00707-2021.full |
| _version_ | 1827931459199959040 |
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| author | Pia Holma Paula Pesonen Olli Mustonen Marjo-Riitta Järvelin Heikki Kauma Juha Auvinen Timo Hautala |
| author_facet | Pia Holma Paula Pesonen Olli Mustonen Marjo-Riitta Järvelin Heikki Kauma Juha Auvinen Timo Hautala |
| author_sort | Pia Holma |
| collection | DOAJ |
| description | Background
Knowledge of pneumonia incidence and risk factors in adults is mainly based on clinical studies of selected patient data and registers with ageing populations. Prospective population-based investigations, such as birth cohort studies, are needed to understand pneumonia incidence and risk factors among young and working-age populations.
Methods
Northern Finland Birth Cohort (NFBC) 1966 data (n=6750) were analysed for pneumonia incidence and risk factors. Incidence analysis was replicated using data from an independent NFBC 1986 cohort (n=9207). Pneumonia in relation to chronic conditions and lifestyle factors was analysed.
Results
A peak with a maximum of 227 pneumonia episodes per 10 000 among men between the ages of 19 and 21 years was found in two independent cohorts. Pneumonia was associated with male sex (relative risk 1.72, 95% CI 1.45–2.04; p<0.001), low educational level (relative risk 2.30, 95% CI 1.72–3.09; p<0.001), smoking (relative risk 1.55, 95% CI 1.31–1.84; p<0.001), asthma (relative risk 2.19, 95% CI 1.73–2.75; p<0.001), cardiovascular diseases (relative risk 2.50, 95% CI 2.04–3.07; p=0.001), kidney diseases (relative risk 4.14, 95% CI 2.81–6.10; p<0.001), rheumatoid arthritis (relative risk 2.69, 95% CI 1.80–4.01; p<0.001), psoriasis (relative risk 2.91, 95% CI 1.92–4.41; p<0.001) and type II diabetes (relative risk 1.80, 95% CI 1.34–2.42; p<0.001). Men with excessive alcohol consumption at age 31 years were at risk of future pneumonia (relative risk 2.40, 95% CI 1.58–3.64; p<0.001).
Conclusions
Birth cohort data can reveal novel high-risk subpopulations, such as young males. Our study provides understanding of pneumonia incidence and risk factors among young and working age populations. |
| first_indexed | 2024-03-13T06:52:59Z |
| format | Article |
| id | doaj.art-aa3feda70b5148e9966963ebf15e513e |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-03-13T06:52:59Z |
| publishDate | 2022-06-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-aa3feda70b5148e9966963ebf15e513e2023-06-07T13:30:09ZengEuropean Respiratory SocietyERJ Open Research2312-05412022-06-018210.1183/23120541.00707-202100707-202152-year follow-up of a birth cohort reveals a high pneumonia incidence among young menPia Holma0Paula Pesonen1Olli Mustonen2Marjo-Riitta Järvelin3Heikki Kauma4Juha Auvinen5Timo Hautala6 Research Unit of Internal Medicine, Dept of Internal Medicine, Division of Infectious Diseases, University of Oulu and Oulu University Hospital, Oulu, Finland Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland Research Unit of Internal Medicine, Dept of Internal Medicine, Division of Infectious Diseases, University of Oulu and Oulu University Hospital, Oulu, Finland Dept of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK Research Unit of Internal Medicine, Dept of Internal Medicine, Division of Infectious Diseases, University of Oulu and Oulu University Hospital, Oulu, Finland Center for Life Course Health Research, University of Oulu, Unit of Primary Care, Oulu University Hospital, Oulu, Finland Research Unit of Internal Medicine, Dept of Internal Medicine, Division of Infectious Diseases, University of Oulu and Oulu University Hospital, Oulu, Finland Background Knowledge of pneumonia incidence and risk factors in adults is mainly based on clinical studies of selected patient data and registers with ageing populations. Prospective population-based investigations, such as birth cohort studies, are needed to understand pneumonia incidence and risk factors among young and working-age populations. Methods Northern Finland Birth Cohort (NFBC) 1966 data (n=6750) were analysed for pneumonia incidence and risk factors. Incidence analysis was replicated using data from an independent NFBC 1986 cohort (n=9207). Pneumonia in relation to chronic conditions and lifestyle factors was analysed. Results A peak with a maximum of 227 pneumonia episodes per 10 000 among men between the ages of 19 and 21 years was found in two independent cohorts. Pneumonia was associated with male sex (relative risk 1.72, 95% CI 1.45–2.04; p<0.001), low educational level (relative risk 2.30, 95% CI 1.72–3.09; p<0.001), smoking (relative risk 1.55, 95% CI 1.31–1.84; p<0.001), asthma (relative risk 2.19, 95% CI 1.73–2.75; p<0.001), cardiovascular diseases (relative risk 2.50, 95% CI 2.04–3.07; p=0.001), kidney diseases (relative risk 4.14, 95% CI 2.81–6.10; p<0.001), rheumatoid arthritis (relative risk 2.69, 95% CI 1.80–4.01; p<0.001), psoriasis (relative risk 2.91, 95% CI 1.92–4.41; p<0.001) and type II diabetes (relative risk 1.80, 95% CI 1.34–2.42; p<0.001). Men with excessive alcohol consumption at age 31 years were at risk of future pneumonia (relative risk 2.40, 95% CI 1.58–3.64; p<0.001). Conclusions Birth cohort data can reveal novel high-risk subpopulations, such as young males. Our study provides understanding of pneumonia incidence and risk factors among young and working age populations.http://openres.ersjournals.com/content/8/2/00707-2021.full |
| spellingShingle | Pia Holma Paula Pesonen Olli Mustonen Marjo-Riitta Järvelin Heikki Kauma Juha Auvinen Timo Hautala 52-year follow-up of a birth cohort reveals a high pneumonia incidence among young men ERJ Open Research |
| title | 52-year follow-up of a birth cohort reveals a high pneumonia incidence among young men |
| title_full | 52-year follow-up of a birth cohort reveals a high pneumonia incidence among young men |
| title_fullStr | 52-year follow-up of a birth cohort reveals a high pneumonia incidence among young men |
| title_full_unstemmed | 52-year follow-up of a birth cohort reveals a high pneumonia incidence among young men |
| title_short | 52-year follow-up of a birth cohort reveals a high pneumonia incidence among young men |
| title_sort | 52 year follow up of a birth cohort reveals a high pneumonia incidence among young men |
| url | http://openres.ersjournals.com/content/8/2/00707-2021.full |
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