Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are prevalent neuropsychiatric disorders and frequently co-occur concomitantly. Individuals suffering from this dual diagnosis often exhibit increased symptom severity and poorer treatment outcomes than those with only one of these...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/1/388 |
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| author | Bo Zhan Yingxin Zhu Jianxun Xia Wenfu Li Ying Tang Anju Beesetty Jiang-Hong Ye Rao Fu |
| author_facet | Bo Zhan Yingxin Zhu Jianxun Xia Wenfu Li Ying Tang Anju Beesetty Jiang-Hong Ye Rao Fu |
| author_sort | Bo Zhan |
| collection | DOAJ |
| description | Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are prevalent neuropsychiatric disorders and frequently co-occur concomitantly. Individuals suffering from this dual diagnosis often exhibit increased symptom severity and poorer treatment outcomes than those with only one of these diseases. Lacking standard preclinical models limited the exploration of neurobiological mechanisms underlying PTSD and AUD comorbidity. In this review, we summarize well-accepted preclinical model paradigms and criteria for developing successful models of comorbidity. We also outline how PTSD and AUD affect each other bidirectionally in the nervous nuclei have been heatedly discussed recently. We hope to provide potential recommendations for future research. |
| first_indexed | 2024-03-11T10:00:07Z |
| format | Article |
| id | doaj.art-aa40e38d08054e6caf3bdad30f618a47 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T10:00:07Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-aa40e38d08054e6caf3bdad30f618a472023-11-16T15:32:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124138810.3390/ijms24010388Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated NeurocircuitryBo Zhan0Yingxin Zhu1Jianxun Xia2Wenfu Li3Ying Tang4Anju Beesetty5Jiang-Hong Ye6Rao Fu7Department of Anatomy, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, ChinaDepartment of Anatomy, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, ChinaDepartment of Basic Medical Sciences, Yunkang School of Medicine and Health, Nanfang College, Guangzhou 510970, ChinaDepartment of Anatomy, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, ChinaDepartment of Biology, School of Life Science, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Anesthesiology, Pharmacology, Physiology & Neuroscience, Rutgers, New Jersey Medical School, The State University of New Jersey, Newark, NJ 07103, USADepartment of Anesthesiology, Pharmacology, Physiology & Neuroscience, Rutgers, New Jersey Medical School, The State University of New Jersey, Newark, NJ 07103, USADepartment of Anatomy, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, ChinaPost-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are prevalent neuropsychiatric disorders and frequently co-occur concomitantly. Individuals suffering from this dual diagnosis often exhibit increased symptom severity and poorer treatment outcomes than those with only one of these diseases. Lacking standard preclinical models limited the exploration of neurobiological mechanisms underlying PTSD and AUD comorbidity. In this review, we summarize well-accepted preclinical model paradigms and criteria for developing successful models of comorbidity. We also outline how PTSD and AUD affect each other bidirectionally in the nervous nuclei have been heatedly discussed recently. We hope to provide potential recommendations for future research.https://www.mdpi.com/1422-0067/24/1/388comorbid PTSD and AUDanimal modelventral tegmental areamesolimbic reward circuithippocampusamygdala |
| spellingShingle | Bo Zhan Yingxin Zhu Jianxun Xia Wenfu Li Ying Tang Anju Beesetty Jiang-Hong Ye Rao Fu Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry International Journal of Molecular Sciences comorbid PTSD and AUD animal model ventral tegmental area mesolimbic reward circuit hippocampus amygdala |
| title | Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry |
| title_full | Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry |
| title_fullStr | Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry |
| title_full_unstemmed | Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry |
| title_short | Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry |
| title_sort | comorbidity of post traumatic stress disorder and alcohol use disorder animal models and associated neurocircuitry |
| topic | comorbid PTSD and AUD animal model ventral tegmental area mesolimbic reward circuit hippocampus amygdala |
| url | https://www.mdpi.com/1422-0067/24/1/388 |
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