Biological Evaluation and Molecular Dynamics Simulation of Chalcone Derivatives as Epidermal Growth Factor-Tyrosine Kinase Inhibitors

Biological Evaluation and Molecular Dynamics Simulation of Chalcone Derivatives as Epidermal Growth Factor-Tyrosine Kinase Inhibitors

Targeted cancer therapy has become a high potential cancer treatment. Epidermal growth factor receptor (EGFR), which plays an important role in cell signaling, enhanced cell survival and proliferation, has been suggested as molecular target for the development of novel cancer therapeutics. In this s...

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Bibliographic Details
Main Authors: Kanyani Sangpheak, Lueacha Tabtimmai, Supaphorn Seetaha, Chompoonut Rungnim, Warinthorn Chavasiri, Peter Wolschann, Kiattawee Choowongkomon, Thanyada Rungrotmongkol
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
chalcone derivatives
cytotoxicity assay
EGFR tyrosine kinase
molecular dynamics simulation
ADMET
Online Access:https://www.mdpi.com/1420-3049/24/6/1092

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