Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins
Abstract Cilia are highly conserved eukaryotic organelles that protrude from the cell surface and are involved in sensory perception, motility, and signaling. Their proper assembly and function rely on the bidirectional intraflagellar transport (IFT) system, which involves motor proteins, including...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2024-01-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-024-06428-9 |
| _version_ | 1797355524541382656 |
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| author | Lin Li Jie Ran |
| author_facet | Lin Li Jie Ran |
| author_sort | Lin Li |
| collection | DOAJ |
| description | Abstract Cilia are highly conserved eukaryotic organelles that protrude from the cell surface and are involved in sensory perception, motility, and signaling. Their proper assembly and function rely on the bidirectional intraflagellar transport (IFT) system, which involves motor proteins, including antegrade kinesins and retrograde dynein. Although the role of IFT-mediated transport in cilia has been extensively studied, recent research has highlighted the contribution of IFT-independent kinesins in ciliary processes. The coordinated activities and interplay between IFT kinesins and IFT-independent kinesins are crucial for maintaining ciliary homeostasis. In this comprehensive review, we aim to delve into the specific contributions and mechanisms of action of the IFT-independent kinesins in cilia. By shedding light on their involvement, we hope to gain a more holistic perspective on ciliogenesis and ciliopathies. |
| first_indexed | 2024-03-08T14:12:24Z |
| format | Article |
| id | doaj.art-aa42694352114a0c846f27253de3bc57 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-03-08T14:12:24Z |
| publishDate | 2024-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-aa42694352114a0c846f27253de3bc572024-01-14T12:38:19ZengNature Publishing GroupCell Death and Disease2041-48892024-01-011511910.1038/s41419-024-06428-9Regulation of ciliary homeostasis by intraflagellar transport-independent kinesinsLin Li0Jie Ran1Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal UniversityCenter for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal UniversityAbstract Cilia are highly conserved eukaryotic organelles that protrude from the cell surface and are involved in sensory perception, motility, and signaling. Their proper assembly and function rely on the bidirectional intraflagellar transport (IFT) system, which involves motor proteins, including antegrade kinesins and retrograde dynein. Although the role of IFT-mediated transport in cilia has been extensively studied, recent research has highlighted the contribution of IFT-independent kinesins in ciliary processes. The coordinated activities and interplay between IFT kinesins and IFT-independent kinesins are crucial for maintaining ciliary homeostasis. In this comprehensive review, we aim to delve into the specific contributions and mechanisms of action of the IFT-independent kinesins in cilia. By shedding light on their involvement, we hope to gain a more holistic perspective on ciliogenesis and ciliopathies.https://doi.org/10.1038/s41419-024-06428-9 |
| spellingShingle | Lin Li Jie Ran Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins Cell Death and Disease |
| title | Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins |
| title_full | Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins |
| title_fullStr | Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins |
| title_full_unstemmed | Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins |
| title_short | Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins |
| title_sort | regulation of ciliary homeostasis by intraflagellar transport independent kinesins |
| url | https://doi.org/10.1038/s41419-024-06428-9 |
| work_keys_str_mv | AT linli regulationofciliaryhomeostasisbyintraflagellartransportindependentkinesins AT jieran regulationofciliaryhomeostasisbyintraflagellartransportindependentkinesins |