Reconstructive Surgery versus Primary Closure following Vulvar Cancer Excision: A Wide Single-Center Experience
(1) Background: plastic reconstruction in vulvar surgery can lead to a better treatment outcome than primary closure. This study aims to compare the preoperative parameters (co-morbidities and tumor size) and postoperative results (tumor free margins and wound healing) between the primary closure an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/7/1695 |
| _version_ | 1797440150645506048 |
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| author | Mustafa Zelal Muallem Jalid Sehouli Andrea Miranda Helmut Plett Ahmad Sayasneh Yasser Diab Jumana Muallem Imad Hatoum |
| author_facet | Mustafa Zelal Muallem Jalid Sehouli Andrea Miranda Helmut Plett Ahmad Sayasneh Yasser Diab Jumana Muallem Imad Hatoum |
| author_sort | Mustafa Zelal Muallem |
| collection | DOAJ |
| description | (1) Background: plastic reconstruction in vulvar surgery can lead to a better treatment outcome than primary closure. This study aims to compare the preoperative parameters (co-morbidities and tumor size) and postoperative results (tumor free margins and wound healing) between the primary closure and reconstructive surgery after vulvar cancer surgery; (2) Methods: this is a retrospective analysis of prospectively collected data from 2009 to 2021 at a tertiary cancer institution; (3) Results: 177 patients were included in the final analysis (51 patients had primary closure PC and 126 had reconstructive surgery RS). About half (49%) of the PC patients had no co-morbidities (<i>p</i> = 0.043). The RS group had a 45 mm median maximal tumor diameter compared to the PC group’s 23 mm (<i>p</i> = 0.013). More than 90% of RS and 80% of PC had tumor-free margins (<i>p</i> = 0.1). Both groups had anterior vulvar excision as the most common surgery (52.4% RS vs. 23.5% PC; <i>p</i> = 0.001). Both groups had identical rates of wound healing disorders. In a median follow-up of 39 months; recurrent disease was found in 23.5% of PC vs. 10.3% in RS (<i>p</i> = 0.012). In terms of overall survival there was no significant difference between the both groups; (4) Conclusions: reconstructive vulvar surgery enables enhanced complete resection rates of larger vulvar tumors with better anatomical restoration and a comparable wound recovery in comparison to primary closure. This results in a lower recurrence rate despite the increased tumor volume. |
| first_indexed | 2024-03-09T12:03:58Z |
| format | Article |
| id | doaj.art-aa437ffed66346468ecbb4f6b9b652c2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T12:03:58Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-aa437ffed66346468ecbb4f6b9b652c22023-11-30T23:00:43ZengMDPI AGCancers2072-66942022-03-01147169510.3390/cancers14071695Reconstructive Surgery versus Primary Closure following Vulvar Cancer Excision: A Wide Single-Center ExperienceMustafa Zelal Muallem0Jalid Sehouli1Andrea Miranda2Helmut Plett3Ahmad Sayasneh4Yasser Diab5Jumana Muallem6Imad Hatoum7Department of Gynecology with Center for Oncological Surgery, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Virchow Campus Clinic, Charité Medical University, 13353 Berlin, GermanyDepartment of Gynecology with Center for Oncological Surgery, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Virchow Campus Clinic, Charité Medical University, 13353 Berlin, GermanyDepartment of Gynecology with Center for Oncological Surgery, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Virchow Campus Clinic, Charité Medical University, 13353 Berlin, GermanyDepartment of Gynecology with Center for Oncological Surgery, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Virchow Campus Clinic, Charité Medical University, 13353 Berlin, GermanyDepartment of Gynecological Oncology, Surgical Oncology Directorate, Guy’s and St Thomas’ NHS Foundation Trust, Faculty of Life Sciences and Medicine, School of Life Course Sciences, King’s College London, Westminster Bridge Road, London SE1 7EH, UKDepartment of Gynecology, Portland Hospital, Portland, VIC 3305, AustraliaDepartment of Gynecology with Center for Oncological Surgery, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Virchow Campus Clinic, Charité Medical University, 13353 Berlin, GermanyDepartment of Gynecology with Center for Oncological Surgery, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Virchow Campus Clinic, Charité Medical University, 13353 Berlin, Germany(1) Background: plastic reconstruction in vulvar surgery can lead to a better treatment outcome than primary closure. This study aims to compare the preoperative parameters (co-morbidities and tumor size) and postoperative results (tumor free margins and wound healing) between the primary closure and reconstructive surgery after vulvar cancer surgery; (2) Methods: this is a retrospective analysis of prospectively collected data from 2009 to 2021 at a tertiary cancer institution; (3) Results: 177 patients were included in the final analysis (51 patients had primary closure PC and 126 had reconstructive surgery RS). About half (49%) of the PC patients had no co-morbidities (<i>p</i> = 0.043). The RS group had a 45 mm median maximal tumor diameter compared to the PC group’s 23 mm (<i>p</i> = 0.013). More than 90% of RS and 80% of PC had tumor-free margins (<i>p</i> = 0.1). Both groups had anterior vulvar excision as the most common surgery (52.4% RS vs. 23.5% PC; <i>p</i> = 0.001). Both groups had identical rates of wound healing disorders. In a median follow-up of 39 months; recurrent disease was found in 23.5% of PC vs. 10.3% in RS (<i>p</i> = 0.012). In terms of overall survival there was no significant difference between the both groups; (4) Conclusions: reconstructive vulvar surgery enables enhanced complete resection rates of larger vulvar tumors with better anatomical restoration and a comparable wound recovery in comparison to primary closure. This results in a lower recurrence rate despite the increased tumor volume.https://www.mdpi.com/2072-6694/14/7/1695vulvar cancerreconstructive surgerywound healingprimary closurevulvectomyflap |
| spellingShingle | Mustafa Zelal Muallem Jalid Sehouli Andrea Miranda Helmut Plett Ahmad Sayasneh Yasser Diab Jumana Muallem Imad Hatoum Reconstructive Surgery versus Primary Closure following Vulvar Cancer Excision: A Wide Single-Center Experience Cancers vulvar cancer reconstructive surgery wound healing primary closure vulvectomy flap |
| title | Reconstructive Surgery versus Primary Closure following Vulvar Cancer Excision: A Wide Single-Center Experience |
| title_full | Reconstructive Surgery versus Primary Closure following Vulvar Cancer Excision: A Wide Single-Center Experience |
| title_fullStr | Reconstructive Surgery versus Primary Closure following Vulvar Cancer Excision: A Wide Single-Center Experience |
| title_full_unstemmed | Reconstructive Surgery versus Primary Closure following Vulvar Cancer Excision: A Wide Single-Center Experience |
| title_short | Reconstructive Surgery versus Primary Closure following Vulvar Cancer Excision: A Wide Single-Center Experience |
| title_sort | reconstructive surgery versus primary closure following vulvar cancer excision a wide single center experience |
| topic | vulvar cancer reconstructive surgery wound healing primary closure vulvectomy flap |
| url | https://www.mdpi.com/2072-6694/14/7/1695 |
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