Association of Digoxin Application Approaches With Long-Term Clinical Outcomes in Rheumatic Heart Disease Patients With Heart Failure: A Retrospective Study
Objective: This retrospective, case–control study was executed to assess the effects of digoxin (DGX) use approaches [continuous use of DGX (cDGX) vs. intermittent use of DGX (iDGX)] on the long-term prognosis in rheumatic heart disease (RHD) patients with heart failure (HF).Methods: A total of 642...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.711203/full |
| _version_ | 1818736408646385664 |
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| author | Cheng Liu Cheng Liu Yanxian Lai Tianwang Guan Qingchun Zeng Jingxian Pei Shenghui Zhang Daihong Wu Deping Wu |
| author_facet | Cheng Liu Cheng Liu Yanxian Lai Tianwang Guan Qingchun Zeng Jingxian Pei Shenghui Zhang Daihong Wu Deping Wu |
| author_sort | Cheng Liu |
| collection | DOAJ |
| description | Objective: This retrospective, case–control study was executed to assess the effects of digoxin (DGX) use approaches [continuous use of DGX (cDGX) vs. intermittent use of DGX (iDGX)] on the long-term prognosis in rheumatic heart disease (RHD) patients with heart failure (HF).Methods: A total of 642 RHD patients were enrolled to this study after propensity matching. The associations of DGX application approaches with the risks of all-cause mortality, cardiovascular death (CVD), HF re-hospitalization (1-, 3-, and 5-year), and new-onset atrial fibrillation (AF) were analyzed by multivariate Cox proportional hazards or binary logistic regression models, respectively.Results: cDGX was associated with increased risks of all-cause mortality (adjusted HR = 1.84, 95% CI: 1.27–2.65, P = 0.001) and CVD (adjusted HR = 2.23, 95% CI: 1.29–3.83, P = 0.004) in RHD patients with HF compared to iDGX. With exception of 1-year HF re-hospitalization risk, cDGX was associated with increased HF re-hospitalization risk of 3-year (adjusted OR = 1.53, 95% CI: 1.03–2.29, P = 0.037) and 5-year (adjusted OR = 1.61, 95% CI: 1.05–2.50, P = 0.031) as well as new-onset AF (adjusted OR = 2.06, 95% CI: 1.09–3.90, P = 0.027).Conclusion: cDGX was significantly associated with increased risks of all-cause mortality, CVD, medium-/long-term HF re-hospitalization, and new-onset AF in RHD patients with HF. |
| first_indexed | 2024-12-18T00:36:41Z |
| format | Article |
| id | doaj.art-aa450ccccda9457d921c2968d471d7d7 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-18T00:36:41Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-aa450ccccda9457d921c2968d471d7d72022-12-21T21:26:59ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-09-01810.3389/fcvm.2021.711203711203Association of Digoxin Application Approaches With Long-Term Clinical Outcomes in Rheumatic Heart Disease Patients With Heart Failure: A Retrospective StudyCheng Liu0Cheng Liu1Yanxian Lai2Tianwang Guan3Qingchun Zeng4Jingxian Pei5Shenghui Zhang6Daihong Wu7Deping Wu8Department of Cardiology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, ChinaDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Cardiology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, ChinaDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaDepartment of Cardiology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, ChinaDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangzhou Center for Disease Control and Prevention, Guangzhou, ChinaObjective: This retrospective, case–control study was executed to assess the effects of digoxin (DGX) use approaches [continuous use of DGX (cDGX) vs. intermittent use of DGX (iDGX)] on the long-term prognosis in rheumatic heart disease (RHD) patients with heart failure (HF).Methods: A total of 642 RHD patients were enrolled to this study after propensity matching. The associations of DGX application approaches with the risks of all-cause mortality, cardiovascular death (CVD), HF re-hospitalization (1-, 3-, and 5-year), and new-onset atrial fibrillation (AF) were analyzed by multivariate Cox proportional hazards or binary logistic regression models, respectively.Results: cDGX was associated with increased risks of all-cause mortality (adjusted HR = 1.84, 95% CI: 1.27–2.65, P = 0.001) and CVD (adjusted HR = 2.23, 95% CI: 1.29–3.83, P = 0.004) in RHD patients with HF compared to iDGX. With exception of 1-year HF re-hospitalization risk, cDGX was associated with increased HF re-hospitalization risk of 3-year (adjusted OR = 1.53, 95% CI: 1.03–2.29, P = 0.037) and 5-year (adjusted OR = 1.61, 95% CI: 1.05–2.50, P = 0.031) as well as new-onset AF (adjusted OR = 2.06, 95% CI: 1.09–3.90, P = 0.027).Conclusion: cDGX was significantly associated with increased risks of all-cause mortality, CVD, medium-/long-term HF re-hospitalization, and new-onset AF in RHD patients with HF.https://www.frontiersin.org/articles/10.3389/fcvm.2021.711203/fullheart failure re-hospitalizationmortalityrheumatic heart diseaseapplication approachesdigoxinnew-onset atrial fibrillation |
| spellingShingle | Cheng Liu Cheng Liu Yanxian Lai Tianwang Guan Qingchun Zeng Jingxian Pei Shenghui Zhang Daihong Wu Deping Wu Association of Digoxin Application Approaches With Long-Term Clinical Outcomes in Rheumatic Heart Disease Patients With Heart Failure: A Retrospective Study Frontiers in Cardiovascular Medicine heart failure re-hospitalization mortality rheumatic heart disease application approaches digoxin new-onset atrial fibrillation |
| title | Association of Digoxin Application Approaches With Long-Term Clinical Outcomes in Rheumatic Heart Disease Patients With Heart Failure: A Retrospective Study |
| title_full | Association of Digoxin Application Approaches With Long-Term Clinical Outcomes in Rheumatic Heart Disease Patients With Heart Failure: A Retrospective Study |
| title_fullStr | Association of Digoxin Application Approaches With Long-Term Clinical Outcomes in Rheumatic Heart Disease Patients With Heart Failure: A Retrospective Study |
| title_full_unstemmed | Association of Digoxin Application Approaches With Long-Term Clinical Outcomes in Rheumatic Heart Disease Patients With Heart Failure: A Retrospective Study |
| title_short | Association of Digoxin Application Approaches With Long-Term Clinical Outcomes in Rheumatic Heart Disease Patients With Heart Failure: A Retrospective Study |
| title_sort | association of digoxin application approaches with long term clinical outcomes in rheumatic heart disease patients with heart failure a retrospective study |
| topic | heart failure re-hospitalization mortality rheumatic heart disease application approaches digoxin new-onset atrial fibrillation |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.711203/full |
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