CRISPR/Cas9-Mediated Disruption of the <i>lef8</i> and <i>lef9</i> to Inhibit Nucleopolyhedrovirus Replication in Silkworms

CRISPR/Cas9-Mediated Disruption of the <i>lef8</i> and <i>lef9</i> to Inhibit Nucleopolyhedrovirus Replication in Silkworms

<i>Bombyx mori</i> nucleopolyhedrovirus (BmNPV) is a pathogen that causes severe disease in silkworms. In a previous study, we demonstrated that by using the CRISPR/Cas9 system to disrupt the BmNPV <i>ie-1</i> and <i>me53</i> genes, transgenic silkworms showed res...

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Bibliographic Details
Main Authors: Yujia Liu, Xiaoqian Zhang, Dongbin Chen, Dehong Yang, Chenxu Zhu, Linmeng Tang, Xu Yang, Yaohui Wang, Xingyu Luo, Manli Wang, Yongping Huang, Zhihong Hu, Zulian Liu
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Viruses
Subjects:
BmNPV
CRISPR/Cas9
transgenic silkworm
antiviral therapy
Online Access:https://www.mdpi.com/1999-4915/14/6/1119

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