Activity of ceruloplasmin in guinea pigs’ trachea in late periods of experimental allergic alveolitis development and their correction with thiotriazolin
We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde ) and antioxidant (ceruloplasmin) systems in guinea pigs’ trachea in experimental allergic alveolitis development. The results of our experimental work have showed a significant accumulat...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2017-04-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/5294 |
| _version_ | 1818034053399445504 |
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| author | Mariana Ljubomurivna Baida |
| author_facet | Mariana Ljubomurivna Baida |
| author_sort | Mariana Ljubomurivna Baida |
| collection | DOAJ |
| description | We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde ) and antioxidant (ceruloplasmin) systems in guinea pigs’ trachea in experimental allergic alveolitis development.
The results of our experimental work have showed a significant accumulation of lipid peroxidation products in the trachea`s tissure in late periods ( on 44th and 54th days) . The state of antioxidant defence was characterized by moderate decrease of ceruloplasmin activity. A potential role of oxidative stress in the pathogenesis of allergic alveolitis has been demonstrated. Increased oxidant levels and decreased antioxidant defences can contribute to the progression of this immune comlex pathology. Reduction of conjugated diene and malondialdehyde content and elevation of ceruloplasmin activity have been reported in animals with this experimental model of disease after using of thiotriazolin. |
| first_indexed | 2024-12-10T06:33:03Z |
| format | Article |
| id | doaj.art-aa47284df1264de7b574a21af2cdfe03 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-10T06:33:03Z |
| publishDate | 2017-04-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-aa47284df1264de7b574a21af2cdfe032022-12-22T01:59:00ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062017-04-017487587910.5281/zenodo.11752964925Activity of ceruloplasmin in guinea pigs’ trachea in late periods of experimental allergic alveolitis development and their correction with thiotriazolinMariana Ljubomurivna Baida0Danylo Halytsky Lviv National Medical UniversityWe have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde ) and antioxidant (ceruloplasmin) systems in guinea pigs’ trachea in experimental allergic alveolitis development. The results of our experimental work have showed a significant accumulation of lipid peroxidation products in the trachea`s tissure in late periods ( on 44th and 54th days) . The state of antioxidant defence was characterized by moderate decrease of ceruloplasmin activity. A potential role of oxidative stress in the pathogenesis of allergic alveolitis has been demonstrated. Increased oxidant levels and decreased antioxidant defences can contribute to the progression of this immune comlex pathology. Reduction of conjugated diene and malondialdehyde content and elevation of ceruloplasmin activity have been reported in animals with this experimental model of disease after using of thiotriazolin.http://www.ojs.ukw.edu.pl/index.php/johs/article/view/5294experimental allergic alveolitis, peroxide lipid oxidation, ceruloplasmin , thiotriazolin |
| spellingShingle | Mariana Ljubomurivna Baida Activity of ceruloplasmin in guinea pigs’ trachea in late periods of experimental allergic alveolitis development and their correction with thiotriazolin Journal of Education, Health and Sport experimental allergic alveolitis, peroxide lipid oxidation, ceruloplasmin , thiotriazolin |
| title | Activity of ceruloplasmin in guinea pigs’ trachea in late periods of experimental allergic alveolitis development and their correction with thiotriazolin |
| title_full | Activity of ceruloplasmin in guinea pigs’ trachea in late periods of experimental allergic alveolitis development and their correction with thiotriazolin |
| title_fullStr | Activity of ceruloplasmin in guinea pigs’ trachea in late periods of experimental allergic alveolitis development and their correction with thiotriazolin |
| title_full_unstemmed | Activity of ceruloplasmin in guinea pigs’ trachea in late periods of experimental allergic alveolitis development and their correction with thiotriazolin |
| title_short | Activity of ceruloplasmin in guinea pigs’ trachea in late periods of experimental allergic alveolitis development and their correction with thiotriazolin |
| title_sort | activity of ceruloplasmin in guinea pigs trachea in late periods of experimental allergic alveolitis development and their correction with thiotriazolin |
| topic | experimental allergic alveolitis, peroxide lipid oxidation, ceruloplasmin , thiotriazolin |
| url | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/5294 |
| work_keys_str_mv | AT marianaljubomurivnabaida activityofceruloplasmininguineapigstracheainlateperiodsofexperimentalallergicalveolitisdevelopmentandtheircorrectionwiththiotriazolin |