Study of Chemical Compositions and Anticancer Effects of <i>Paris polyphylla</i> var. <i>Chinensis</i> Leaves
<i>Paris polyphylla</i> var. <i>chinensis</i> (Franch.) Hara is a perennial herb belonging to the Trilliaceae family. Ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q–TOF MS) was used to detect the composition of different fractions o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/9/2724 |
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| author | Feng Su Lv Ye Zilin Zhou An Su Jinping Gu Zili Guo Peixi Zhu Weike Su |
| author_facet | Feng Su Lv Ye Zilin Zhou An Su Jinping Gu Zili Guo Peixi Zhu Weike Su |
| author_sort | Feng Su |
| collection | DOAJ |
| description | <i>Paris polyphylla</i> var. <i>chinensis</i> (Franch.) Hara is a perennial herb belonging to the Trilliaceae family. Ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q–TOF MS) was used to detect the composition of different fractions of <i>Paris polyphylla</i> var. <i>chinensis</i> leaves. Meanwhile, the extracts of different fractions were evaluated for their cytotoxic activities against four selected human cancer cell lines and one human normal epithelial cell line based on the MTT assay method. Multivariate statistical analysis was performed to screen differential compounds and to analyze the distributions between different fractions. Finally, more than 60 compounds were obtained and identified from the different fractions of <i>Paris polyphylla</i> var. <i>chinensis</i> leaves, and the chloroform and n−butanol extracts showed significant cytotoxic effects on these four cancer cells. Several compounds were preliminarily identified from different fractions, including 36 steroidal saponins, 11 flavonoids, 10 ceramides, 8 lipids, 6 organic acids, and 8 other compounds. Various compounds were screened out as different chemical components of different fractions, which were considered as a potential substance basis for the cytotoxicity of <i>Paris polyphylla</i> var. <i>chinensis</i> leaves. |
| first_indexed | 2024-03-10T03:54:52Z |
| format | Article |
| id | doaj.art-aa490a5d4a7a4462ac23db91bc84913e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:54:52Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-aa490a5d4a7a4462ac23db91bc84913e2023-11-23T08:48:43ZengMDPI AGMolecules1420-30492022-04-01279272410.3390/molecules27092724Study of Chemical Compositions and Anticancer Effects of <i>Paris polyphylla</i> var. <i>Chinensis</i> LeavesFeng Su0Lv Ye1Zilin Zhou2An Su3Jinping Gu4Zili Guo5Peixi Zhu6Weike Su7College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, ChinaZhejiang Yangtze Delta Region Pharmaceutical Technology Research Park, Hangzhou 310014, ChinaCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China<i>Paris polyphylla</i> var. <i>chinensis</i> (Franch.) Hara is a perennial herb belonging to the Trilliaceae family. Ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q–TOF MS) was used to detect the composition of different fractions of <i>Paris polyphylla</i> var. <i>chinensis</i> leaves. Meanwhile, the extracts of different fractions were evaluated for their cytotoxic activities against four selected human cancer cell lines and one human normal epithelial cell line based on the MTT assay method. Multivariate statistical analysis was performed to screen differential compounds and to analyze the distributions between different fractions. Finally, more than 60 compounds were obtained and identified from the different fractions of <i>Paris polyphylla</i> var. <i>chinensis</i> leaves, and the chloroform and n−butanol extracts showed significant cytotoxic effects on these four cancer cells. Several compounds were preliminarily identified from different fractions, including 36 steroidal saponins, 11 flavonoids, 10 ceramides, 8 lipids, 6 organic acids, and 8 other compounds. Various compounds were screened out as different chemical components of different fractions, which were considered as a potential substance basis for the cytotoxicity of <i>Paris polyphylla</i> var. <i>chinensis</i> leaves.https://www.mdpi.com/1420-3049/27/9/2724<i>Paris polyphylla</i> var. <i>chinensis</i>leavesidentificationcytotoxic effect |
| spellingShingle | Feng Su Lv Ye Zilin Zhou An Su Jinping Gu Zili Guo Peixi Zhu Weike Su Study of Chemical Compositions and Anticancer Effects of <i>Paris polyphylla</i> var. <i>Chinensis</i> Leaves Molecules <i>Paris polyphylla</i> var. <i>chinensis</i> leaves identification cytotoxic effect |
| title | Study of Chemical Compositions and Anticancer Effects of <i>Paris polyphylla</i> var. <i>Chinensis</i> Leaves |
| title_full | Study of Chemical Compositions and Anticancer Effects of <i>Paris polyphylla</i> var. <i>Chinensis</i> Leaves |
| title_fullStr | Study of Chemical Compositions and Anticancer Effects of <i>Paris polyphylla</i> var. <i>Chinensis</i> Leaves |
| title_full_unstemmed | Study of Chemical Compositions and Anticancer Effects of <i>Paris polyphylla</i> var. <i>Chinensis</i> Leaves |
| title_short | Study of Chemical Compositions and Anticancer Effects of <i>Paris polyphylla</i> var. <i>Chinensis</i> Leaves |
| title_sort | study of chemical compositions and anticancer effects of i paris polyphylla i var i chinensis i leaves |
| topic | <i>Paris polyphylla</i> var. <i>chinensis</i> leaves identification cytotoxic effect |
| url | https://www.mdpi.com/1420-3049/27/9/2724 |
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