Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings
Objectives: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail. Methods: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologi...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S120197122300749X |
| _version_ | 1827620835865657344 |
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| author | Giuseppe Rossi Jon Salmanton-García Chiara Cattaneo Francesco Marchesi Julio Dávila-Valls Sonia Martín-Pérez Federico Itri Alberto López-García Andreas Glenthøj Maria Gomes da Silva Caroline Besson Monia Marchetti Barbora Weinbergerová Ozren Jaksic Moraima Jiménez Yavuz M. Bilgin Jaap Van Doesum Francesca Farina Pavel Žák Luisa Verga Graham P. Collins Valentina Bonuomo Jens Van Praet Marcio Nucci Stef Meers Ildefonso Espigado Nicola S. Fracchiolla Toni Valković Christian Bjørn Poulsen Natasha Čolović Giulia Dragonetti Marie-Pierre Ledoux Carlo Tascini Caterina Buquicchio Ola Blennow Francesco Passamonti Marina Machado Jorge Labrador Rafael F. Duarte Martin Schönlein Lucia Prezioso Iker Falces-Romero Austin Kulasekararaj Carolina Garcia-Vidal Noemí Fernández Ghaith Abu-Zeinah Irati Ormazabal-Vélez Tatjana Adžić-Vukičević Klára Piukovics Igor Stoma Annarosa Cuccaro Gabriele Magliano Tomáš Szotkowski Tomás-José González-López Shaimaa El-Ashwah Rui Bergantim Uluhan Sili Johan Maertens Fatih Demirkan Cristina De Ramón Verena Petzer Maria Ilaria Del Principe Milan Navrátil Michelina Dargenio Guldane Cengiz Seval Michail Samarkos Zdeněk Ráčil László Imre Pinczés Tobias Lahmer Alessandro Busca Gustavo-Adolfo Méndez Antonio Vena Monika M. Biernat Maria Merelli Maria Calbacho Aleksandra Barać Martina Bavastro Alessandro Limongelli Osman Ilhan Dominik Wolf Gökçe Melis Çolak Ramón García-Sanz Ziad Emarah Bojana Mišković Stefanie K. Gräfe Miloš Mladenović Tommaso Francesco Aiello Lucía Núñez-Martín-Buitrago Anna Nordlander Elena Arellano Giovanni Paolo Maria Zambrotta Emanuele Ammatuna Alba Cabirta Maria Vittoria Sacchi Raquel Nunes Rodrigues Ditte Stampe Hersby Michaela Hanakova Laman Rahimli Raul Cordoba Oliver A. Cornely Livio Pagano Joyce MARQUES DE ALMEIDA José-Ángel HERNÁNDEZ-RIVAS Anna GUIDETTI Olimpia FINIZIO Zlate STOJANOSKI Milche CVETANOSKI Joseph MELETIADIS Nick DE JONGE Darko ANTIĆ Natasha ALI Maria Chiara TISI Laura SERRANO Gaëtan PLANTEFEVE Nina KHANNA Martin HOENIGL Martin ČERŇAN Carolina MIRANDA-CASTILLO María FERNÁNDEZ-GALÁN Alexandra SERRIS Nurettin ERBEN Rémy DULÉRY Avinash AUJAYEB Mario Virgilio PAPA Jan NOVÁK Mario DELIA Giuseppe SAPIENZA Florian REIZINE Ali S. OMRANI Roberta DI BLASI Sylvain LAMURE Ľuboš DRGOŇA Nicola COPPOLA Josip BATINIĆ Murtadha AL-KHABORI José-María RIBERA-SANTA SUSANA Monica PIEDIMONTE Jorge LOUREIRO-AMIGO Guillemette FOUQUET Rita FAZZI François DANION Jörg SCHUBERT Baerbel HOELL-NEUGEBAUER Nathan C. BAHR Ayel Omar YAHIA Ana TORRES-ATIENZA Ikhwan RINALDI Marina POPOVA Hans-Beier OMMEN Maria Enza MITRA Malgorzata MIKULSKA Ira LACEJ Sofya KHOSTELIDI Sein WIN Donald VINH Modar SALEH Juergen PRATTES Pavel JINDRA Fabio GUOLO Roberta DELLA PEPA Ekaterina CHELYSHEVA Przemyslaw ZDZIARSKI Vivien WAI-MAN Andrés SOTO-SILVA Hans Martin ORTH Sandra MALAK Lisset LORENZO DE LA PEÑA Martin KOLDITZ Chi Shan KHO Christopher H. HEATH Ana GROH Eleni GAVRIILAKI Monica FUNG Matthias EGGER Elizabeth DE KORT Erik DE CABO Tania CUSHION Fazle Rabbi CHOWDHURY M. Mansour CEESAY Mathias BREHON Gina VARRICCHIO Agostino TAFURI María-Josefa JIMÉNEZ-LORENZO Nikolai KLIMKO Panagiotis TSIRIGOTIS Anastasia ANTONIADOU Maria VEHRESCHILD |
| author_facet | Giuseppe Rossi Jon Salmanton-García Chiara Cattaneo Francesco Marchesi Julio Dávila-Valls Sonia Martín-Pérez Federico Itri Alberto López-García Andreas Glenthøj Maria Gomes da Silva Caroline Besson Monia Marchetti Barbora Weinbergerová Ozren Jaksic Moraima Jiménez Yavuz M. Bilgin Jaap Van Doesum Francesca Farina Pavel Žák Luisa Verga Graham P. Collins Valentina Bonuomo Jens Van Praet Marcio Nucci Stef Meers Ildefonso Espigado Nicola S. Fracchiolla Toni Valković Christian Bjørn Poulsen Natasha Čolović Giulia Dragonetti Marie-Pierre Ledoux Carlo Tascini Caterina Buquicchio Ola Blennow Francesco Passamonti Marina Machado Jorge Labrador Rafael F. Duarte Martin Schönlein Lucia Prezioso Iker Falces-Romero Austin Kulasekararaj Carolina Garcia-Vidal Noemí Fernández Ghaith Abu-Zeinah Irati Ormazabal-Vélez Tatjana Adžić-Vukičević Klára Piukovics Igor Stoma Annarosa Cuccaro Gabriele Magliano Tomáš Szotkowski Tomás-José González-López Shaimaa El-Ashwah Rui Bergantim Uluhan Sili Johan Maertens Fatih Demirkan Cristina De Ramón Verena Petzer Maria Ilaria Del Principe Milan Navrátil Michelina Dargenio Guldane Cengiz Seval Michail Samarkos Zdeněk Ráčil László Imre Pinczés Tobias Lahmer Alessandro Busca Gustavo-Adolfo Méndez Antonio Vena Monika M. Biernat Maria Merelli Maria Calbacho Aleksandra Barać Martina Bavastro Alessandro Limongelli Osman Ilhan Dominik Wolf Gökçe Melis Çolak Ramón García-Sanz Ziad Emarah Bojana Mišković Stefanie K. Gräfe Miloš Mladenović Tommaso Francesco Aiello Lucía Núñez-Martín-Buitrago Anna Nordlander Elena Arellano Giovanni Paolo Maria Zambrotta Emanuele Ammatuna Alba Cabirta Maria Vittoria Sacchi Raquel Nunes Rodrigues Ditte Stampe Hersby Michaela Hanakova Laman Rahimli Raul Cordoba Oliver A. Cornely Livio Pagano Joyce MARQUES DE ALMEIDA José-Ángel HERNÁNDEZ-RIVAS Anna GUIDETTI Olimpia FINIZIO Zlate STOJANOSKI Milche CVETANOSKI Joseph MELETIADIS Nick DE JONGE Darko ANTIĆ Natasha ALI Maria Chiara TISI Laura SERRANO Gaëtan PLANTEFEVE Nina KHANNA Martin HOENIGL Martin ČERŇAN Carolina MIRANDA-CASTILLO María FERNÁNDEZ-GALÁN Alexandra SERRIS Nurettin ERBEN Rémy DULÉRY Avinash AUJAYEB Mario Virgilio PAPA Jan NOVÁK Mario DELIA Giuseppe SAPIENZA Florian REIZINE Ali S. OMRANI Roberta DI BLASI Sylvain LAMURE Ľuboš DRGOŇA Nicola COPPOLA Josip BATINIĆ Murtadha AL-KHABORI José-María RIBERA-SANTA SUSANA Monica PIEDIMONTE Jorge LOUREIRO-AMIGO Guillemette FOUQUET Rita FAZZI François DANION Jörg SCHUBERT Baerbel HOELL-NEUGEBAUER Nathan C. BAHR Ayel Omar YAHIA Ana TORRES-ATIENZA Ikhwan RINALDI Marina POPOVA Hans-Beier OMMEN Maria Enza MITRA Malgorzata MIKULSKA Ira LACEJ Sofya KHOSTELIDI Sein WIN Donald VINH Modar SALEH Juergen PRATTES Pavel JINDRA Fabio GUOLO Roberta DELLA PEPA Ekaterina CHELYSHEVA Przemyslaw ZDZIARSKI Vivien WAI-MAN Andrés SOTO-SILVA Hans Martin ORTH Sandra MALAK Lisset LORENZO DE LA PEÑA Martin KOLDITZ Chi Shan KHO Christopher H. HEATH Ana GROH Eleni GAVRIILAKI Monica FUNG Matthias EGGER Elizabeth DE KORT Erik DE CABO Tania CUSHION Fazle Rabbi CHOWDHURY M. Mansour CEESAY Mathias BREHON Gina VARRICCHIO Agostino TAFURI María-Josefa JIMÉNEZ-LORENZO Nikolai KLIMKO Panagiotis TSIRIGOTIS Anastasia ANTONIADOU Maria VEHRESCHILD |
| author_sort | Giuseppe Rossi |
| collection | DOAJ |
| description | Objectives: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail. Methods: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy. Results: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment. Conclusion: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts. |
| first_indexed | 2024-03-09T10:53:35Z |
| format | Article |
| id | doaj.art-aa4b6d8a89d84411a2e61988f6142a0f |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-03-09T10:53:35Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-aa4b6d8a89d84411a2e61988f6142a0f2023-12-01T05:00:54ZengElsevierInternational Journal of Infectious Diseases1201-97122023-12-0113798110Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findingsGiuseppe Rossi0Jon Salmanton-García1Chiara Cattaneo2Francesco Marchesi3Julio Dávila-Valls4Sonia Martín-Pérez5Federico Itri6Alberto López-García7Andreas Glenthøj8Maria Gomes da Silva9Caroline Besson10Monia Marchetti11Barbora Weinbergerová12Ozren Jaksic13Moraima Jiménez14Yavuz M. Bilgin15Jaap Van Doesum16Francesca Farina17Pavel Žák18Luisa Verga19Graham P. Collins20Valentina Bonuomo21Jens Van Praet22Marcio Nucci23Stef Meers24Ildefonso Espigado25Nicola S. Fracchiolla26Toni Valković27Christian Bjørn Poulsen28Natasha Čolović29Giulia Dragonetti30Marie-Pierre Ledoux31Carlo Tascini32Caterina Buquicchio33Ola Blennow34Francesco Passamonti35Marina Machado36Jorge Labrador37Rafael F. Duarte38Martin Schönlein39Lucia Prezioso40Iker Falces-Romero41Austin Kulasekararaj42Carolina Garcia-Vidal43Noemí Fernández44Ghaith Abu-Zeinah45Irati Ormazabal-Vélez46Tatjana Adžić-Vukičević47Klára Piukovics48Igor Stoma49Annarosa Cuccaro50Gabriele Magliano51Tomáš Szotkowski52Tomás-José González-López53Shaimaa El-Ashwah54Rui Bergantim55Uluhan Sili56Johan Maertens57Fatih Demirkan58Cristina De Ramón59Verena Petzer60Maria Ilaria Del Principe61Milan Navrátil62Michelina Dargenio63Guldane Cengiz Seval64Michail Samarkos65Zdeněk Ráčil66László Imre Pinczés67Tobias Lahmer68Alessandro Busca69Gustavo-Adolfo Méndez70Antonio Vena71Monika M. Biernat72Maria Merelli73Maria Calbacho74Aleksandra Barać75Martina Bavastro76Alessandro Limongelli77Osman Ilhan78Dominik Wolf79Gökçe Melis Çolak80Ramón García-Sanz81Ziad Emarah82Bojana Mišković83Stefanie K. Gräfe84Miloš Mladenović85Tommaso Francesco Aiello86Lucía Núñez-Martín-Buitrago87Anna Nordlander88Elena Arellano89Giovanni Paolo Maria Zambrotta90Emanuele Ammatuna91Alba Cabirta92Maria Vittoria Sacchi93Raquel Nunes Rodrigues94Ditte Stampe Hersby95Michaela Hanakova96Laman Rahimli97Raul Cordoba98Oliver A. Cornely99Livio Pagano100Joyce MARQUES DE ALMEIDAJosé-Ángel HERNÁNDEZ-RIVASAnna GUIDETTIOlimpia FINIZIOZlate STOJANOSKIMilche CVETANOSKIJoseph MELETIADISNick DE JONGEDarko ANTIĆNatasha ALIMaria Chiara TISILaura SERRANOGaëtan PLANTEFEVENina KHANNAMartin HOENIGLMartin ČERŇANCarolina MIRANDA-CASTILLOMaría FERNÁNDEZ-GALÁNAlexandra SERRISNurettin ERBENRémy DULÉRYAvinash AUJAYEBMario Virgilio PAPAJan NOVÁKMario DELIAGiuseppe SAPIENZAFlorian REIZINEAli S. OMRANIRoberta DI BLASISylvain LAMUREĽuboš DRGOŇANicola COPPOLAJosip BATINIĆMurtadha AL-KHABORIJosé-María RIBERA-SANTA SUSANAMonica PIEDIMONTEJorge LOUREIRO-AMIGOGuillemette FOUQUETRita FAZZIFrançois DANIONJörg SCHUBERTBaerbel HOELL-NEUGEBAUERNathan C. BAHRAyel Omar YAHIAAna TORRES-ATIENZAIkhwan RINALDIMarina POPOVAHans-Beier OMMENMaria Enza MITRAMalgorzata MIKULSKAIra LACEJSofya KHOSTELIDISein WINDonald VINHModar SALEHJuergen PRATTESPavel JINDRAFabio GUOLORoberta DELLA PEPAEkaterina CHELYSHEVAPrzemyslaw ZDZIARSKIVivien WAI-MANAndrés SOTO-SILVAHans Martin ORTHSandra MALAKLisset LORENZO DE LA PEÑAMartin KOLDITZChi Shan KHOChristopher H. HEATHAna GROHEleni GAVRIILAKIMonica FUNGMatthias EGGERElizabeth DE KORTErik DE CABOTania CUSHIONFazle Rabbi CHOWDHURYM. Mansour CEESAYMathias BREHONGina VARRICCHIOAgostino TAFURIMaría-Josefa JIMÉNEZ-LORENZONikolai KLIMKOPanagiotis TSIRIGOTISAnastasia ANTONIADOUMaria VEHRESCHILDHematology Unit, ASST-Spedali Civili, Brescia, ItalyUniversity of Cologne, Faculty of Medicine, and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany; Corresponding author: Tel.: +49 221 478 85523; fax: +49 221 478 1421445.Hematology Unit, ASST-Spedali Civili, Brescia, ItalyHematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, ItalyHospital Nuestra Señora de Sonsoles, Ávila, SpainHospital Nuestra Señora de Sonsoles, Ávila, SpainSan Luigi Gonzaga Hospital - Orbassano, Orbassano, ItalyFundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, SpainDepartment of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, DenmarkPortuguese Institute of Oncology, Lisbon, PortugalCentre Hospitalier de Versailles, Le Chesnay, France; Université Paris-Saclay, UVSQ, Inserm, Équipe ''Exposome et Hérédité'', CESP, Villejuif, FranceAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, ItalyDepartment of Internal Medicine - Hematology and Oncology, Masaryk University Hospital Brno, Brno, Czech RepublicDepartment of Hematology, University Hospital Dubrava, Zagreb, CroatiaDepartment of Hematology, Vacute lymphoid leukaemia d'Hebron Hospital Universitari, Experimental Hematology, Vacute lymphoid leukaemia d'Hebron Institute of Oncology (VHIO), Vacute lymphoid leukaemia d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, SpainDepartment of Internal Medicine, ADRZ, Goes, NetherlandsUniversity Medical Center Groningen, Groningen, NetherlandsIRCCS Ospedale San Raffaele, Milan, ItalyUniversity Hospital Hradec Králové, Hradec Králové, Czech RepublicAzienda Ospedaliera San Gerardo - Monza, Monza, Italy; Università Milano-Bicocca, Milan, ItalyNIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, United KingdomDepartment of Medicine, Section of Hematology, University of Verona, Verona, Italy; Department of Clinical and Biological Sciences, University of Turin, Turin, ItalyDepartment of Nephrology and Infectious diseases, AZ Sint-Jan Brugge-Oostende AV, Brugge, BelgiumFederal University of Rio de Janeiro, Rio de Janeiro, BrazilAZ KLINA, Brasschaat, BelgiumDepartment of Hematology, University Hospital Virgen Macarena - University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS / CSIC), Universidad de Sevilla (Departamento de Medicina), Seville, SpainFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyUniversity Hospital Centre Rijeka, Rijeka, Croatia; Croatian Cooperative Group for Hematological Diseases (CROHEM), Faculty of Medicine and Faculty of Health Studies University of Rijeka, Rijeka, CroatiaZealand University Hospital, Roskilde, Roskilde, DenmarkUniversity Clinical Center Serbia, Medical Faculty University Belgrade, Belgrade, SerbiaHematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, ItalyICANS, Strasbourg, FranceAzienda Sanitaria Universitaria del Friuli Centrale, Udine, ItalyEmatologia con Trapianto, Ospedale Dimiccoli Barletta, Barletta, ItalyDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm, SwedenDepartment of Medicine and Surgery, University of Insubria and ASST Sette Laghi, Ospedale di Circolo of Varese, Varese, ItalyClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainDepartment of Hematology, Research Unit, Hospital Universitario de Burgos, Burgos, SpainHospital Universitario Puerta de Hierro, Majadahonda, SpainDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyHospital University of Parma - Hematology and Bone Marrow Unit, Parma, ItalyLa Paz University Hospital, Madrid, Spain; CIBERINFEC, Instituto de Salud Carlos III, Madrid, SpainKing's College Hospital, London, United Kingdom; King's College London, London, United KingdomHospital Clinic, Barcelona, SpainHospital Universitario Marqués de Valdecilla, Santander, SpainDivision of Hematology and Oncology, Weill Cornell Medicine, New York, United StatesComplejo Hospitalario de Navarra, Iruña-Pamplona, SpainCOVID hospital ''Batajnica'', Belgrade, SerbiaDepartment of Internal Medicine, South Division Faculty of Medicine University of Szeged, Szeged, HungaryGomel State Medical University, Gomel, BelarusHematology Unit, Center for Translational Medicine, Azienda USL Toscana NordOvest, Livorno, ItalyASST Grande Ospedale Metropolitano Niguarda, Milan, ItalyUniversity Hospital Olomouc, Olomouc, Czech RepublicDepartment of Hematology, Hospital Universitario de Burgos, Burgos, SpainOncology Center, Mansoura University, Mansoura, EgyptCentro Hospitalar e Universitário São João, Porto, PortugalDepartment of Infectious Diseases and Clinical Microbiology, School of Medicine, Marmara University, Istanbul, TurkeyDepartment of Microbiology, Immunology, and Transplantation, KULeuven, Leuven and Department of Hematology, UZ Leuven, Leuven, BelgiumDokuz Eylul University, Division of Hematology, Izmir, TurkeyHematology Department, Hospital Universitario de Salamanca, Salamanca, Spain; IBSAL, Centro de Investigación del Cáncer-IBMCC (USAL-CSIC), Salamanca, SpainDepartment of Hematology and Oncology, Medical University of Innsbruck, Innsbruck, AustriaHematology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, ItalyHead of the ICU and Transplant Unit, Department of Hematooncology, University Hospital of Ostrava, Ostrava-Poruba, Czech RepublicHematology and Stem Cell Transplant Unit, Vito Fazzi, LecceAnkara University, Ankara, TurkeyLaikon Hospital, Athens, GreeceInstitute of Hematology and Blood Transfusion, Prague, Czech RepublicDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, HungaryMedizinische Klinik II, Klinikum rechts der Isar, TU München, Munich, GermanyStem Cell Transplant Center, AOU Citta' della Salute e della Scienza, Turin, ItalyHospital Escuela de Agudos Dr. Ramón Madariaga, Posadas, ArgentinaIRCCS AOU San Martino (IRCCS Ospedale Policlinico San Martino), Genova, ItaliaDepartment of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, PolandAzienda Sanitaria Universitaria del Friuli Centrale, Udine, ItalyHospital Universitario 12 de Octubre, Madrid, SpainClinic of Hematology, Clinical Center of Serbia, Belgrade, SerbiaIRCCS AOU San Martino (IRCCS Ospedale Policlinico San Martino), Genova, ItaliaIRCCS AOU San Martino (IRCCS Ospedale Policlinico San Martino), Genova, ItaliaAnkara University, Ankara, TurkeyDepartment of Hematology and Oncology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Infectious Diseases and Clinical Microbiology, School of Medicine, Marmara University, Istanbul, TurkeyIBSAL, Centro de Investigación del Cáncer-IBMCC (USAL-CSIC), Salamanca, Spain; Head of Molecular Biology an HLA Unit, Department of Hematology, University Hospital of Salamanca (HUS/IBSAL/CIBERONC), Salamanca, SpainOncology Center, Mansoura University, Mansoura, EgyptHospital Clinic, Barcelona, Spain; Clinic for Orthopedic Surgery and Traumatology, University Clinical Center of Serbia, Belgrade, SerbiaUniversity of Cologne, Faculty of Medicine, and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyHospital Clinic, Barcelona, SpainHospital Clinic, Barcelona, SpainHospital Universitario Puerta de Hierro, Majadahonda, SpainDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm, SwedenDepartment of Hematology, University Hospital Virgen Macarena - University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS / CSIC), Universidad de Sevilla (Departamento de Medicina), Seville, SpainAzienda Ospedaliera San Gerardo - Monza, Monza, Italy; Università Milano-Bicocca, Milan, ItalyUniversity Medical Center Groningen, Groningen, NetherlandsDepartment of Hematology, Vacute lymphoid leukaemia d'Hebron Hospital Universitari, Experimental Hematology, Vacute lymphoid leukaemia d'Hebron Institute of Oncology (VHIO), Vacute lymphoid leukaemia d'Hebron Barcelona Hospital Campus, Barcelona, SpainAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, ItalyPortuguese Institute of Oncology, Lisbon, PortugalDepartment of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, DenmarkInstitute of Hematology and Blood Transfusion, Prague, Czech RepublicUniversity of Cologne, Faculty of Medicine, and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, GermanyFundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, SpainUniversity of Cologne, Faculty of Medicine, and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany; University of Cologne, Faculty of Medicine, and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), Cologne, Germany; University of Cologne, Faculty of Medicine, and University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, GermanyHematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy; Hematology Unit, Università Cattolica del Sacro Cuore, Rome, ItalyObjectives: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail. Methods: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy. Results: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment. Conclusion: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.http://www.sciencedirect.com/science/article/pii/S120197122300749XElderlySARS-CoV-2Hematological malignancyHigh-risk patientCOVID-19 |
| spellingShingle | Giuseppe Rossi Jon Salmanton-García Chiara Cattaneo Francesco Marchesi Julio Dávila-Valls Sonia Martín-Pérez Federico Itri Alberto López-García Andreas Glenthøj Maria Gomes da Silva Caroline Besson Monia Marchetti Barbora Weinbergerová Ozren Jaksic Moraima Jiménez Yavuz M. Bilgin Jaap Van Doesum Francesca Farina Pavel Žák Luisa Verga Graham P. Collins Valentina Bonuomo Jens Van Praet Marcio Nucci Stef Meers Ildefonso Espigado Nicola S. Fracchiolla Toni Valković Christian Bjørn Poulsen Natasha Čolović Giulia Dragonetti Marie-Pierre Ledoux Carlo Tascini Caterina Buquicchio Ola Blennow Francesco Passamonti Marina Machado Jorge Labrador Rafael F. Duarte Martin Schönlein Lucia Prezioso Iker Falces-Romero Austin Kulasekararaj Carolina Garcia-Vidal Noemí Fernández Ghaith Abu-Zeinah Irati Ormazabal-Vélez Tatjana Adžić-Vukičević Klára Piukovics Igor Stoma Annarosa Cuccaro Gabriele Magliano Tomáš Szotkowski Tomás-José González-López Shaimaa El-Ashwah Rui Bergantim Uluhan Sili Johan Maertens Fatih Demirkan Cristina De Ramón Verena Petzer Maria Ilaria Del Principe Milan Navrátil Michelina Dargenio Guldane Cengiz Seval Michail Samarkos Zdeněk Ráčil László Imre Pinczés Tobias Lahmer Alessandro Busca Gustavo-Adolfo Méndez Antonio Vena Monika M. Biernat Maria Merelli Maria Calbacho Aleksandra Barać Martina Bavastro Alessandro Limongelli Osman Ilhan Dominik Wolf Gökçe Melis Çolak Ramón García-Sanz Ziad Emarah Bojana Mišković Stefanie K. Gräfe Miloš Mladenović Tommaso Francesco Aiello Lucía Núñez-Martín-Buitrago Anna Nordlander Elena Arellano Giovanni Paolo Maria Zambrotta Emanuele Ammatuna Alba Cabirta Maria Vittoria Sacchi Raquel Nunes Rodrigues Ditte Stampe Hersby Michaela Hanakova Laman Rahimli Raul Cordoba Oliver A. Cornely Livio Pagano Joyce MARQUES DE ALMEIDA José-Ángel HERNÁNDEZ-RIVAS Anna GUIDETTI Olimpia FINIZIO Zlate STOJANOSKI Milche CVETANOSKI Joseph MELETIADIS Nick DE JONGE Darko ANTIĆ Natasha ALI Maria Chiara TISI Laura SERRANO Gaëtan PLANTEFEVE Nina KHANNA Martin HOENIGL Martin ČERŇAN Carolina MIRANDA-CASTILLO María FERNÁNDEZ-GALÁN Alexandra SERRIS Nurettin ERBEN Rémy DULÉRY Avinash AUJAYEB Mario Virgilio PAPA Jan NOVÁK Mario DELIA Giuseppe SAPIENZA Florian REIZINE Ali S. OMRANI Roberta DI BLASI Sylvain LAMURE Ľuboš DRGOŇA Nicola COPPOLA Josip BATINIĆ Murtadha AL-KHABORI José-María RIBERA-SANTA SUSANA Monica PIEDIMONTE Jorge LOUREIRO-AMIGO Guillemette FOUQUET Rita FAZZI François DANION Jörg SCHUBERT Baerbel HOELL-NEUGEBAUER Nathan C. BAHR Ayel Omar YAHIA Ana TORRES-ATIENZA Ikhwan RINALDI Marina POPOVA Hans-Beier OMMEN Maria Enza MITRA Malgorzata MIKULSKA Ira LACEJ Sofya KHOSTELIDI Sein WIN Donald VINH Modar SALEH Juergen PRATTES Pavel JINDRA Fabio GUOLO Roberta DELLA PEPA Ekaterina CHELYSHEVA Przemyslaw ZDZIARSKI Vivien WAI-MAN Andrés SOTO-SILVA Hans Martin ORTH Sandra MALAK Lisset LORENZO DE LA PEÑA Martin KOLDITZ Chi Shan KHO Christopher H. HEATH Ana GROH Eleni GAVRIILAKI Monica FUNG Matthias EGGER Elizabeth DE KORT Erik DE CABO Tania CUSHION Fazle Rabbi CHOWDHURY M. Mansour CEESAY Mathias BREHON Gina VARRICCHIO Agostino TAFURI María-Josefa JIMÉNEZ-LORENZO Nikolai KLIMKO Panagiotis TSIRIGOTIS Anastasia ANTONIADOU Maria VEHRESCHILD Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings International Journal of Infectious Diseases Elderly SARS-CoV-2 Hematological malignancy High-risk patient COVID-19 |
| title | Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings |
| title_full | Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings |
| title_fullStr | Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings |
| title_full_unstemmed | Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings |
| title_short | Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings |
| title_sort | age successive waves immunization and mortality in elderly covid 19 hematological patients epicovideha findings |
| topic | Elderly SARS-CoV-2 Hematological malignancy High-risk patient COVID-19 |
| url | http://www.sciencedirect.com/science/article/pii/S120197122300749X |
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