Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse.

Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse.

Actin depolymerizing factor-homology (ADF-H) family proteins regulate actin filament dynamics at multiple cellular locations. Herein, we have investigated the function of the ADF-H family member coactosin-like 1 (COTL1) in the regulation of actin dynamics at the T cell immune synapse (IS). We initia...

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Bibliographic Details
Main Authors: Joanna Kim, Michael J Shapiro, Adebowale O Bamidele, Pinar Gurel, Puspa Thapa, Henry N Higgs, Karen E Hedin, Virginia S Shapiro, Daniel D Billadeau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3890291?pdf=render

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