Mitochondrial Dysfunction in Rheumatoid Arthritis
Rheumatoid arthritis, a chronic autoimmune disease with complex etiology, is characterized by excessive proliferation of synovial cells, massive production of inflammatory cells and cartilage destruction. Studies have shown that mitochondrial dysfunction plays an important role in promoting the occu...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/9/1216 |
| _version_ | 1827663063479746560 |
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| author | Chen Ma Jie Wang Fenfang Hong Shulong Yang |
| author_facet | Chen Ma Jie Wang Fenfang Hong Shulong Yang |
| author_sort | Chen Ma |
| collection | DOAJ |
| description | Rheumatoid arthritis, a chronic autoimmune disease with complex etiology, is characterized by excessive proliferation of synovial cells, massive production of inflammatory cells and cartilage destruction. Studies have shown that mitochondrial dysfunction plays an important role in promoting the occurrence of RA. Mitochondria with normal structure and function are essential for the normal survival of chondrocytes and synovial cells. Once mitochondrial function is destroyed, it will affect the survival, activation and differentiation of immune cells and non-immune cells involved in the pathogenesis of RA, thus leading to the occurrence of RA. However, the mechanism of mitochondrial dysfunction in RA remains unclear. This article reviews the method of mitochondrial dysfunction leading to RA, the effects of mitochondrial dysfunction on immune cells, the etiology of mitochondrial dysfunction in RA, and the pathology of mitochondrial dysfunction in RA. We also outline some drugs that can exert therapeutic effects on RA which are associated with modulating mitochondrial activity. The understanding and summary of mitochondrial dysfunction in RA may provide new research directions for pathological intervention and prevention of RA. |
| first_indexed | 2024-03-10T00:37:31Z |
| format | Article |
| id | doaj.art-aa4ce502f076453bb54ff2e08aebe39f |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T00:37:31Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-aa4ce502f076453bb54ff2e08aebe39f2023-11-23T15:14:50ZengMDPI AGBiomolecules2218-273X2022-09-01129121610.3390/biom12091216Mitochondrial Dysfunction in Rheumatoid ArthritisChen Ma0Jie Wang1Fenfang Hong2Shulong Yang3Experimental Center of Pathogen Biology, College of Medicine, Nanchang University, Nanchang 330006, ChinaDepartment of Graduate, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan 250117, ChinaExperimental Center of Pathogen Biology, College of Medicine, Nanchang University, Nanchang 330006, ChinaKey Laboratory of Chronic Diseases, Fuzhou Medical College, Nanchang University, Fuzhou 344099, ChinaRheumatoid arthritis, a chronic autoimmune disease with complex etiology, is characterized by excessive proliferation of synovial cells, massive production of inflammatory cells and cartilage destruction. Studies have shown that mitochondrial dysfunction plays an important role in promoting the occurrence of RA. Mitochondria with normal structure and function are essential for the normal survival of chondrocytes and synovial cells. Once mitochondrial function is destroyed, it will affect the survival, activation and differentiation of immune cells and non-immune cells involved in the pathogenesis of RA, thus leading to the occurrence of RA. However, the mechanism of mitochondrial dysfunction in RA remains unclear. This article reviews the method of mitochondrial dysfunction leading to RA, the effects of mitochondrial dysfunction on immune cells, the etiology of mitochondrial dysfunction in RA, and the pathology of mitochondrial dysfunction in RA. We also outline some drugs that can exert therapeutic effects on RA which are associated with modulating mitochondrial activity. The understanding and summary of mitochondrial dysfunction in RA may provide new research directions for pathological intervention and prevention of RA.https://www.mdpi.com/2218-273X/12/9/1216mitochondriarheumatoid arthritis |
| spellingShingle | Chen Ma Jie Wang Fenfang Hong Shulong Yang Mitochondrial Dysfunction in Rheumatoid Arthritis Biomolecules mitochondria rheumatoid arthritis |
| title | Mitochondrial Dysfunction in Rheumatoid Arthritis |
| title_full | Mitochondrial Dysfunction in Rheumatoid Arthritis |
| title_fullStr | Mitochondrial Dysfunction in Rheumatoid Arthritis |
| title_full_unstemmed | Mitochondrial Dysfunction in Rheumatoid Arthritis |
| title_short | Mitochondrial Dysfunction in Rheumatoid Arthritis |
| title_sort | mitochondrial dysfunction in rheumatoid arthritis |
| topic | mitochondria rheumatoid arthritis |
| url | https://www.mdpi.com/2218-273X/12/9/1216 |
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