A Whole New Comprehension about ncRNA-Encoded Peptides/Proteins in Cancers
It is generally considered that non-coding RNAs do not encode proteins; however, more recently, studies have shown that lncRNAs and circRNAs have ORFs which are regions that code for peptides/protein. On account of the lack of 5′cap structure, translation of circRNAs is driven by IRESs, m6A modifica...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/21/5196 |
| _version_ | 1797468872660484096 |
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| author | Qinnan Chen Hongyu Shen Fengqi Nie Ming Sun |
| author_facet | Qinnan Chen Hongyu Shen Fengqi Nie Ming Sun |
| author_sort | Qinnan Chen |
| collection | DOAJ |
| description | It is generally considered that non-coding RNAs do not encode proteins; however, more recently, studies have shown that lncRNAs and circRNAs have ORFs which are regions that code for peptides/protein. On account of the lack of 5′cap structure, translation of circRNAs is driven by IRESs, m6A modification or through rolling amplification. An increasing body of evidence have revealed different functions and mechanisms of ncRNA-encoded peptides/proteins in cancers, including regulation of signal transduction (Wnt/β-catenin signaling, AKT-related signaling, MAPK signaling and other signaling), cellular metabolism (Glucose metabolism and Lipid metabolism), protein stability, transcriptional regulation, posttranscriptional regulation (regulation of RNA stability, mRNA splicing and translation initiation). In addition, we conclude the existing detection technologies and the potential of clinical applications in cancer therapy. |
| first_indexed | 2024-03-09T19:13:32Z |
| format | Article |
| id | doaj.art-aa4cf3df60104a72974425479542e720 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T19:13:32Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-aa4cf3df60104a72974425479542e7202023-11-24T04:00:37ZengMDPI AGCancers2072-66942022-10-011421519610.3390/cancers14215196A Whole New Comprehension about ncRNA-Encoded Peptides/Proteins in CancersQinnan Chen0Hongyu Shen1Fengqi Nie2Ming Sun3Department of Clinical Medicine, Jiangsu Health Vocational College, 69 Huangshanling Rd., Nanjing 211800, ChinaDepartment of Oncology Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, 458 Shizi St., Suzhou 215026, ChinaDepartment of Oncology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Rd., Nanjing 210003, ChinaDepartment of Oncology Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, 458 Shizi St., Suzhou 215026, ChinaIt is generally considered that non-coding RNAs do not encode proteins; however, more recently, studies have shown that lncRNAs and circRNAs have ORFs which are regions that code for peptides/protein. On account of the lack of 5′cap structure, translation of circRNAs is driven by IRESs, m6A modification or through rolling amplification. An increasing body of evidence have revealed different functions and mechanisms of ncRNA-encoded peptides/proteins in cancers, including regulation of signal transduction (Wnt/β-catenin signaling, AKT-related signaling, MAPK signaling and other signaling), cellular metabolism (Glucose metabolism and Lipid metabolism), protein stability, transcriptional regulation, posttranscriptional regulation (regulation of RNA stability, mRNA splicing and translation initiation). In addition, we conclude the existing detection technologies and the potential of clinical applications in cancer therapy.https://www.mdpi.com/2072-6694/14/21/5196peptides/proteins encoded by ncRNAstranslation mechanismcancersclinical applications |
| spellingShingle | Qinnan Chen Hongyu Shen Fengqi Nie Ming Sun A Whole New Comprehension about ncRNA-Encoded Peptides/Proteins in Cancers Cancers peptides/proteins encoded by ncRNAs translation mechanism cancers clinical applications |
| title | A Whole New Comprehension about ncRNA-Encoded Peptides/Proteins in Cancers |
| title_full | A Whole New Comprehension about ncRNA-Encoded Peptides/Proteins in Cancers |
| title_fullStr | A Whole New Comprehension about ncRNA-Encoded Peptides/Proteins in Cancers |
| title_full_unstemmed | A Whole New Comprehension about ncRNA-Encoded Peptides/Proteins in Cancers |
| title_short | A Whole New Comprehension about ncRNA-Encoded Peptides/Proteins in Cancers |
| title_sort | whole new comprehension about ncrna encoded peptides proteins in cancers |
| topic | peptides/proteins encoded by ncRNAs translation mechanism cancers clinical applications |
| url | https://www.mdpi.com/2072-6694/14/21/5196 |
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