Chronic exposure to IL-6 induces a desensitized phenotype of the microglia

Chronic exposure to IL-6 induces a desensitized phenotype of the microglia

Abstract Background When the homeostasis of the central nervous system (CNS) is altered, microglial cells become activated displaying a wide range of phenotypes that depend on the specific site, the nature of the activator, and particularly the microenvironment generated by the lesion. Cytokines are...

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Bibliographic Details
Main Authors: Mireia Recasens, Beatriz Almolda, Jeús Pérez-Clausell, Iain L. Campbell, Berta González, Bernardo Castellano
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
Axonal sprouting
Primed microglia
T cell
Monocyte
MHCII
Online Access:https://doi.org/10.1186/s12974-020-02063-1

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