The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment
Chemokines govern leukocyte migration by attracting cells that express their cognate ligands. Many cancer types show altered chemokine secretion profiles, favoring the recruitment of pro-tumorigenic immune cells and preventing the accumulation of anti-tumorigenic effector cells. This can ultimately...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02159/full |
| _version_ | 1811326039120412672 |
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| author | Katharina Helene Susek Maria Karvouni Evren Alici Evren Alici Andreas Lundqvist Andreas Lundqvist |
| author_facet | Katharina Helene Susek Maria Karvouni Evren Alici Evren Alici Andreas Lundqvist Andreas Lundqvist |
| author_sort | Katharina Helene Susek |
| collection | DOAJ |
| description | Chemokines govern leukocyte migration by attracting cells that express their cognate ligands. Many cancer types show altered chemokine secretion profiles, favoring the recruitment of pro-tumorigenic immune cells and preventing the accumulation of anti-tumorigenic effector cells. This can ultimately result in cancer immune evasion. The manipulation of chemokine and chemokine-receptor signaling can reshape the immunological phenotypes within the tumor microenvironment in order to increase the therapeutic efficacy of cancer immunotherapy. Here we discuss the three chemokine-chemokine receptor axes, CXCR1/2–CXCL1-3/5-8, CXCR3–CXCL9/10/11, and CXCR4-CXCL12 and their role on pro-tumorigenic immune cells and anti-tumorigenic effector cells in solid tumors. In particular, we summarize current strategies to target these axes and discuss their potential use in treatment approaches. |
| first_indexed | 2024-04-13T14:42:53Z |
| format | Article |
| id | doaj.art-aa4e03f0258d4862a02516b6ca6a222e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T14:42:53Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-aa4e03f0258d4862a02516b6ca6a222e2022-12-22T02:42:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-09-01910.3389/fimmu.2018.02159402002The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor MicroenvironmentKatharina Helene Susek0Maria Karvouni1Evren Alici2Evren Alici3Andreas Lundqvist4Andreas Lundqvist5Department of Medicine, Karolinska Institutet (KI), Solna, SwedenDepartment of Medicine, Karolinska Institutet (KI), Solna, SwedenDepartment of Medicine, Karolinska Institutet (KI), Solna, SwedenCell Therapy Institute, Nova Southeastern University, Fort Lauderdale, FL, United StatesCell Therapy Institute, Nova Southeastern University, Fort Lauderdale, FL, United StatesDepartment of Oncology-Pathology, Karolinska Institutet (KI), Solna, SwedenChemokines govern leukocyte migration by attracting cells that express their cognate ligands. Many cancer types show altered chemokine secretion profiles, favoring the recruitment of pro-tumorigenic immune cells and preventing the accumulation of anti-tumorigenic effector cells. This can ultimately result in cancer immune evasion. The manipulation of chemokine and chemokine-receptor signaling can reshape the immunological phenotypes within the tumor microenvironment in order to increase the therapeutic efficacy of cancer immunotherapy. Here we discuss the three chemokine-chemokine receptor axes, CXCR1/2–CXCL1-3/5-8, CXCR3–CXCL9/10/11, and CXCR4-CXCL12 and their role on pro-tumorigenic immune cells and anti-tumorigenic effector cells in solid tumors. In particular, we summarize current strategies to target these axes and discuss their potential use in treatment approaches.https://www.frontiersin.org/article/10.3389/fimmu.2018.02159/fullchemokinescancer immunotherapymetastasisNK cellsT cellsmyeloid cells |
| spellingShingle | Katharina Helene Susek Maria Karvouni Evren Alici Evren Alici Andreas Lundqvist Andreas Lundqvist The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment Frontiers in Immunology chemokines cancer immunotherapy metastasis NK cells T cells myeloid cells |
| title | The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment |
| title_full | The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment |
| title_fullStr | The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment |
| title_full_unstemmed | The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment |
| title_short | The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment |
| title_sort | role of cxc chemokine receptors 1 4 on immune cells in the tumor microenvironment |
| topic | chemokines cancer immunotherapy metastasis NK cells T cells myeloid cells |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02159/full |
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