Central Administration of BIBP3226, Neuropeptide Y (NPY) Y1 Receptor Antagonist, does not Inhibit Fasting- and NPY-Induced Food Intake in Neonatal Chicks
Neuropeptide Y (NPY) is known to be an essential orexigenic signal in mammalian and avian brain. Since NPY receptors in the avian brain have not been clarified, to determine whether Y1 receptor or Y1-like receptor(s) mediates the orexigenic effect of NPY in neonatal chicks was examined by using BIBP...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Japan Poultry Science Association
2001-10-01
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| Series: | The Journal of Poultry Science |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpsa/38/4/38_4_259/_pdf/-char/en |
| Summary: | Neuropeptide Y (NPY) is known to be an essential orexigenic signal in mammalian and avian brain. Since NPY receptors in the avian brain have not been clarified, to determine whether Y1 receptor or Y1-like receptor(s) mediates the orexigenic effect of NPY in neonatal chicks was examined by using BIBP3226, a selective nonpeptide Y1 receptor antagonist for mammals. Central administration of BIBP3226 (5 or 10μg) did not alter fasting-induced food intake in Experiment 1. In the second experiment, when BIBP3226 (5μg) and NPY (0.5μg) were co-administrated, BIBP3226 did not abolish NPY-induced food intake. These results suggest that Y1- or Y1-like receptor(s) do not play a significant role in regulating food intake of the neonatal chick. |
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| ISSN: | 1346-7395 1349-0486 |