Four-year effects of exercise on fatigue and physical activity in patients with cancer
Abstract Background In the earlier randomized controlled Physical Activity during Cancer Treatment (PACT) study, we found beneficial effects of an 18-week supervised exercise program on fatigue in patients with newly diagnosed breast or colon cancer undergoing adjuvant treatment. The present study a...
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| Format: | Article |
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BMC
2018-06-01
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| Series: | BMC Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12916-018-1075-x |
| _version_ | 1811278841372475392 |
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| author | Lenja Witlox Anouk E. Hiensch Miranda J. Velthuis Charlotte N. Steins Bisschop Maartje Los Frans L. G. Erdkamp Haiko J. Bloemendal Marlies Verhaar Daan ten Bokkel Huinink Elsken van der Wall Petra H. M. Peeters Anne M. May |
| author_facet | Lenja Witlox Anouk E. Hiensch Miranda J. Velthuis Charlotte N. Steins Bisschop Maartje Los Frans L. G. Erdkamp Haiko J. Bloemendal Marlies Verhaar Daan ten Bokkel Huinink Elsken van der Wall Petra H. M. Peeters Anne M. May |
| author_sort | Lenja Witlox |
| collection | DOAJ |
| description | Abstract Background In the earlier randomized controlled Physical Activity during Cancer Treatment (PACT) study, we found beneficial effects of an 18-week supervised exercise program on fatigue in patients with newly diagnosed breast or colon cancer undergoing adjuvant treatment. The present study assessed long-term effects of the exercise program on levels of fatigue and physical activity 4 years after participation in the PACT study. Methods The original study was a two-armed, multicenter randomized controlled trial comparing an 18-week supervised exercise program to usual care among 204 breast cancer patients and 33 colon cancer patients undergoing adjuvant treatment. Of the 237 PACT participants, 197 participants were eligible and approached to participate in the 4-year post-baseline measurements, and 128 patients responded. We assessed fatigue and physical activity levels at 4 years post-baseline and compared this to levels at baseline, post-intervention (18 weeks post-baseline), and at 36 weeks post-baseline. Results Intention-to-treat mixed linear effects model analyses showed that cancer patients in the intervention group reported significantly higher moderate-to-vigorous total physical activity levels (141.46 min/week (95% confidence interval (CI) 1.31, 281.61, effect size (ES) = 0.22) after 4 years compared to the usual care group. Furthermore, cancer patients in the intervention group tended to experience less physical fatigue at 4 years post-baseline compared to the usual care group (− 1.13, 95% CI –2.45, 0.20, ES = 0.22), although the result was not statistically significant. Conclusion Patients with breast or colon cancer who participated in the 18-week exercise intervention showed significant higher levels of moderate-to-vigorous total physical activity levels and a tendency towards lower physical fatigue levels 4 years post-baseline. Our result indicate that exercising during chemotherapy is a promising strategy for minimizing treatment-related side effects, both short and long term. Trial registration Current Controlled Trials ISRCTN43801571, Dutch Trial Register NTR2138. Trial registered on 9 December 2009. |
| first_indexed | 2024-04-13T00:43:35Z |
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| id | doaj.art-aa4f15db4abc44ea875e738b8c37b5ea |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-04-13T00:43:35Z |
| publishDate | 2018-06-01 |
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| series | BMC Medicine |
| spelling | doaj.art-aa4f15db4abc44ea875e738b8c37b5ea2022-12-22T03:10:05ZengBMCBMC Medicine1741-70152018-06-011611910.1186/s12916-018-1075-xFour-year effects of exercise on fatigue and physical activity in patients with cancerLenja Witlox0Anouk E. Hiensch1Miranda J. Velthuis2Charlotte N. Steins Bisschop3Maartje Los4Frans L. G. Erdkamp5Haiko J. Bloemendal6Marlies Verhaar7Daan ten Bokkel Huinink8Elsken van der Wall9Petra H. M. Peeters10Anne M. May11Department of Clinical Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht UniversityDepartment of Clinical Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht UniversityNetherlands Comprehensive Cancer Organisation (IKNL)Department of Clinical Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht UniversityDepartment of Medical Oncology, St. Antonius ZiekenhuisDepartment of Internal Medicine - Medical Oncology, Obis Medisch CentrumDepartment of Internal Medicine, Meander Medical CenterDepartment of Internal Medicine, Hofpoort ZiekenhuisDepartment of Internal Medicine, DiakonessenhuisDepartment of Medical Oncology, University Medical Center Utrecht, Utrecht UniversityDepartment of Clinical Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht UniversityDepartment of Clinical Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht UniversityAbstract Background In the earlier randomized controlled Physical Activity during Cancer Treatment (PACT) study, we found beneficial effects of an 18-week supervised exercise program on fatigue in patients with newly diagnosed breast or colon cancer undergoing adjuvant treatment. The present study assessed long-term effects of the exercise program on levels of fatigue and physical activity 4 years after participation in the PACT study. Methods The original study was a two-armed, multicenter randomized controlled trial comparing an 18-week supervised exercise program to usual care among 204 breast cancer patients and 33 colon cancer patients undergoing adjuvant treatment. Of the 237 PACT participants, 197 participants were eligible and approached to participate in the 4-year post-baseline measurements, and 128 patients responded. We assessed fatigue and physical activity levels at 4 years post-baseline and compared this to levels at baseline, post-intervention (18 weeks post-baseline), and at 36 weeks post-baseline. Results Intention-to-treat mixed linear effects model analyses showed that cancer patients in the intervention group reported significantly higher moderate-to-vigorous total physical activity levels (141.46 min/week (95% confidence interval (CI) 1.31, 281.61, effect size (ES) = 0.22) after 4 years compared to the usual care group. Furthermore, cancer patients in the intervention group tended to experience less physical fatigue at 4 years post-baseline compared to the usual care group (− 1.13, 95% CI –2.45, 0.20, ES = 0.22), although the result was not statistically significant. Conclusion Patients with breast or colon cancer who participated in the 18-week exercise intervention showed significant higher levels of moderate-to-vigorous total physical activity levels and a tendency towards lower physical fatigue levels 4 years post-baseline. Our result indicate that exercising during chemotherapy is a promising strategy for minimizing treatment-related side effects, both short and long term. Trial registration Current Controlled Trials ISRCTN43801571, Dutch Trial Register NTR2138. Trial registered on 9 December 2009.http://link.springer.com/article/10.1186/s12916-018-1075-xCancerExercise interventionChemotherapyFatiguePhysical activityLong-term effects |
| spellingShingle | Lenja Witlox Anouk E. Hiensch Miranda J. Velthuis Charlotte N. Steins Bisschop Maartje Los Frans L. G. Erdkamp Haiko J. Bloemendal Marlies Verhaar Daan ten Bokkel Huinink Elsken van der Wall Petra H. M. Peeters Anne M. May Four-year effects of exercise on fatigue and physical activity in patients with cancer BMC Medicine Cancer Exercise intervention Chemotherapy Fatigue Physical activity Long-term effects |
| title | Four-year effects of exercise on fatigue and physical activity in patients with cancer |
| title_full | Four-year effects of exercise on fatigue and physical activity in patients with cancer |
| title_fullStr | Four-year effects of exercise on fatigue and physical activity in patients with cancer |
| title_full_unstemmed | Four-year effects of exercise on fatigue and physical activity in patients with cancer |
| title_short | Four-year effects of exercise on fatigue and physical activity in patients with cancer |
| title_sort | four year effects of exercise on fatigue and physical activity in patients with cancer |
| topic | Cancer Exercise intervention Chemotherapy Fatigue Physical activity Long-term effects |
| url | http://link.springer.com/article/10.1186/s12916-018-1075-x |
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