Are cadmium and lead levels linked to the development of anxiety and depression? - A systematic review of observational studies
The aim of this systematic review was to assess if cadmium and lead levels are linked to anxiety and depression. A systematic literature search was conducted to identify observational trials evaluating the impact of cadmium and lead on the incidence and phenotype of depression and anxiety. The searc...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651321003225 |
| _version_ | 1818600494695710720 |
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| author | Anna Maria Cybulska Szymon Grochans Magdalena Sylwia Kamińska Mateusz Bosiacki Karolina Skonieczna-Żydecka Elżbieta Grochans |
| author_facet | Anna Maria Cybulska Szymon Grochans Magdalena Sylwia Kamińska Mateusz Bosiacki Karolina Skonieczna-Żydecka Elżbieta Grochans |
| author_sort | Anna Maria Cybulska |
| collection | DOAJ |
| description | The aim of this systematic review was to assess if cadmium and lead levels are linked to anxiety and depression. A systematic literature search was conducted to identify observational trials evaluating the impact of cadmium and lead on the incidence and phenotype of depression and anxiety. The search identified 1059 records. Overall eighteen studies comprising 28,304 participants with a female predominance (n = 19,483; 69%) were included. Cadmium and lead levels were analyzed in eight and thirteen studies, respectively. Five studies found an association between blood cadmium levels and depression, among them three trials which reported that individuals in the highest quartile of blood cadmium had higher odds of showing depressive symptoms. Sex and smoking status were found to be potential confounders of cadmium impact on the depressive phenotype. None of the studies found association between the level of anxiety and blood cadmium levels. Nine studies demonstrated association between depressive symptoms and blood lead concentration. High lead levels may be associated with anxiety and neurobehavioral deficits. There are many factors that influence both the levels of cadmium and lead, and the severity of depression and anxiety in the respondents. There is no clear evidence for the impact of cadmium and lead levels on the development of depressive symptoms but a lot of indirect evidence points to this. |
| first_indexed | 2024-12-16T12:36:23Z |
| format | Article |
| id | doaj.art-aa4fb8e41de74d1aa7f8cd431e4df511 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-12-16T12:36:23Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-aa4fb8e41de74d1aa7f8cd431e4df5112022-12-21T22:31:33ZengElsevierEcotoxicology and Environmental Safety0147-65132021-06-01216112211Are cadmium and lead levels linked to the development of anxiety and depression? - A systematic review of observational studiesAnna Maria Cybulska0Szymon Grochans1Magdalena Sylwia Kamińska2Mateusz Bosiacki3Karolina Skonieczna-Żydecka4Elżbieta Grochans5Department of Nursing, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, 48 Żołnierska St., 71-210 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, 72 Powstańców Wielkopolskich St., 70-111, Szczecin, PolandSubdepartment of Long-Term Care and Palliative Medicine, Department of Social Medicine, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, 48 Żołnierska St., 71-210 Szczecin, Poland; Corresponding author.Department of Functional Diagnostics and Physical Medicine, Pomeranian Medical University in Szczecin, Żołnierska 54 Str., 71-210 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 24 Broniewskiego St., 71-460 Szczecin, PolandDepartment of Nursing, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, 48 Żołnierska St., 71-210 Szczecin, PolandThe aim of this systematic review was to assess if cadmium and lead levels are linked to anxiety and depression. A systematic literature search was conducted to identify observational trials evaluating the impact of cadmium and lead on the incidence and phenotype of depression and anxiety. The search identified 1059 records. Overall eighteen studies comprising 28,304 participants with a female predominance (n = 19,483; 69%) were included. Cadmium and lead levels were analyzed in eight and thirteen studies, respectively. Five studies found an association between blood cadmium levels and depression, among them three trials which reported that individuals in the highest quartile of blood cadmium had higher odds of showing depressive symptoms. Sex and smoking status were found to be potential confounders of cadmium impact on the depressive phenotype. None of the studies found association between the level of anxiety and blood cadmium levels. Nine studies demonstrated association between depressive symptoms and blood lead concentration. High lead levels may be associated with anxiety and neurobehavioral deficits. There are many factors that influence both the levels of cadmium and lead, and the severity of depression and anxiety in the respondents. There is no clear evidence for the impact of cadmium and lead levels on the development of depressive symptoms but a lot of indirect evidence points to this.http://www.sciencedirect.com/science/article/pii/S0147651321003225CadmiumLeadAnxietyDepression |
| spellingShingle | Anna Maria Cybulska Szymon Grochans Magdalena Sylwia Kamińska Mateusz Bosiacki Karolina Skonieczna-Żydecka Elżbieta Grochans Are cadmium and lead levels linked to the development of anxiety and depression? - A systematic review of observational studies Ecotoxicology and Environmental Safety Cadmium Lead Anxiety Depression |
| title | Are cadmium and lead levels linked to the development of anxiety and depression? - A systematic review of observational studies |
| title_full | Are cadmium and lead levels linked to the development of anxiety and depression? - A systematic review of observational studies |
| title_fullStr | Are cadmium and lead levels linked to the development of anxiety and depression? - A systematic review of observational studies |
| title_full_unstemmed | Are cadmium and lead levels linked to the development of anxiety and depression? - A systematic review of observational studies |
| title_short | Are cadmium and lead levels linked to the development of anxiety and depression? - A systematic review of observational studies |
| title_sort | are cadmium and lead levels linked to the development of anxiety and depression a systematic review of observational studies |
| topic | Cadmium Lead Anxiety Depression |
| url | http://www.sciencedirect.com/science/article/pii/S0147651321003225 |
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