Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis

Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis

Abnormal expression of Forkhead box protein M1 (FOXM1) and serine/threonine kinase Budding uninhibited by benzimidazoles 1 (BUB1B) contributes to the development and progression of several cancers, including chronic myelogenous leukemia (CML). However, the molecular mechanism of the FOXM1/BUB1B regu...

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Bibliographic Details
Main Authors: Shilpa Kuttikrishnan, Tariq Masoodi, Gulab Sher, Ajaz A. Bhat, Kalyani Patil, Tamam El-Elimat, Nicholas H. Oberlies, Cedric J. Pearce, Mohmmad Haris, Aamir Ahmad, Feras Q. Alali, Shahab Uddin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
fungal metabolites
Neosetophomone B
FOXM1
BUB1B
apoptosis
leukemia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.929996/full

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