Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of <i>Sanghuangporus vaninii</i> and <i>Inonotus hispidus</i> in Rodent Models
Acute inflammation and hyperuricemia are associated with gouty arthritis. As an edible and therapeutic mushroom, <i>Sanghuangporus vaninii</i> (SV) has an inhibitory effect on tumorigenesis, and <i>Inonotus hispidus</i> (IH) exhibits anti-tumor, anti-inflammatory, and antioxi...
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MDPI AG
2022-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/20/4421 |
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| author | Zhen Sun Zhige Li Yunyun Tan Xiuxiu Wang Chunxia Wang Mingyuan Dong Honghan Liu Heng Chen Yu Li Lanzhou Li Di Wang |
| author_facet | Zhen Sun Zhige Li Yunyun Tan Xiuxiu Wang Chunxia Wang Mingyuan Dong Honghan Liu Heng Chen Yu Li Lanzhou Li Di Wang |
| author_sort | Zhen Sun |
| collection | DOAJ |
| description | Acute inflammation and hyperuricemia are associated with gouty arthritis. As an edible and therapeutic mushroom, <i>Sanghuangporus vaninii</i> (SV) has an inhibitory effect on tumorigenesis, and <i>Inonotus hispidus</i> (IH) exhibits anti-tumor, anti-inflammatory, and antioxidant properties. In this study, uric acid (UA) and xanthine oxidase (XOD) levels in hyperuricemic mice were examined to determine the regulatory effects of SV and IH. SV and IH reversed the pathogenic state of elevated UA levels in the serum and reduced levels of XOD in the serum and liver of mice with hyperuricemia. SV and IH affected the inflammatory response in rats with acute gouty arthritis. Compared to vehicle-treated rats, monosodium urate crystals (MSU) increased the swelling ratio of the right ankle joints. SV and IH administration significantly reduced swelling and inflammatory cell infiltration. SV reduced the levels of interleukin-8 (IL-8) and chemokine ligand-2 (CCL-2), whereas IH reduced the levels of matrix metalloproteinase-9 (MMP-9), CCL-2, and tumor necrosis factor-α (TNF-α), which were confirmed in articular soft tissues by immunohistochemistry. In summary, our data provide experimental evidence for the applicability of SV and IH in gouty arthritis and hyperuricemia treatment. |
| first_indexed | 2024-03-09T19:38:20Z |
| format | Article |
| id | doaj.art-aa50ce3a2d4f44d998be62c12809f01c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T19:38:20Z |
| publishDate | 2022-10-01 |
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| series | Nutrients |
| spelling | doaj.art-aa50ce3a2d4f44d998be62c12809f01c2023-11-24T01:46:34ZengMDPI AGNutrients2072-66432022-10-011420442110.3390/nu14204421Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of <i>Sanghuangporus vaninii</i> and <i>Inonotus hispidus</i> in Rodent ModelsZhen Sun0Zhige Li1Yunyun Tan2Xiuxiu Wang3Chunxia Wang4Mingyuan Dong5Honghan Liu6Heng Chen7Yu Li8Lanzhou Li9Di Wang10Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, ChinaEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, ChinaEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, ChinaEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, ChinaEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, ChinaSchool of Life Sciences, Jilin University, Changchun 130012, ChinaSchool of Life Sciences, Jilin University, Changchun 130012, ChinaEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, ChinaEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, ChinaEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, ChinaEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, ChinaAcute inflammation and hyperuricemia are associated with gouty arthritis. As an edible and therapeutic mushroom, <i>Sanghuangporus vaninii</i> (SV) has an inhibitory effect on tumorigenesis, and <i>Inonotus hispidus</i> (IH) exhibits anti-tumor, anti-inflammatory, and antioxidant properties. In this study, uric acid (UA) and xanthine oxidase (XOD) levels in hyperuricemic mice were examined to determine the regulatory effects of SV and IH. SV and IH reversed the pathogenic state of elevated UA levels in the serum and reduced levels of XOD in the serum and liver of mice with hyperuricemia. SV and IH affected the inflammatory response in rats with acute gouty arthritis. Compared to vehicle-treated rats, monosodium urate crystals (MSU) increased the swelling ratio of the right ankle joints. SV and IH administration significantly reduced swelling and inflammatory cell infiltration. SV reduced the levels of interleukin-8 (IL-8) and chemokine ligand-2 (CCL-2), whereas IH reduced the levels of matrix metalloproteinase-9 (MMP-9), CCL-2, and tumor necrosis factor-α (TNF-α), which were confirmed in articular soft tissues by immunohistochemistry. In summary, our data provide experimental evidence for the applicability of SV and IH in gouty arthritis and hyperuricemia treatment.https://www.mdpi.com/2072-6643/14/20/4421<i>Sanghuangporus vaninii</i><i>Inonotus hispidus</i>hyperuricemiagouty arthritisinflammation |
| spellingShingle | Zhen Sun Zhige Li Yunyun Tan Xiuxiu Wang Chunxia Wang Mingyuan Dong Honghan Liu Heng Chen Yu Li Lanzhou Li Di Wang Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of <i>Sanghuangporus vaninii</i> and <i>Inonotus hispidus</i> in Rodent Models Nutrients <i>Sanghuangporus vaninii</i> <i>Inonotus hispidus</i> hyperuricemia gouty arthritis inflammation |
| title | Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of <i>Sanghuangporus vaninii</i> and <i>Inonotus hispidus</i> in Rodent Models |
| title_full | Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of <i>Sanghuangporus vaninii</i> and <i>Inonotus hispidus</i> in Rodent Models |
| title_fullStr | Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of <i>Sanghuangporus vaninii</i> and <i>Inonotus hispidus</i> in Rodent Models |
| title_full_unstemmed | Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of <i>Sanghuangporus vaninii</i> and <i>Inonotus hispidus</i> in Rodent Models |
| title_short | Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of <i>Sanghuangporus vaninii</i> and <i>Inonotus hispidus</i> in Rodent Models |
| title_sort | anti gouty arthritis and anti hyperuricemia properties of i sanghuangporus vaninii i and i inonotus hispidus i in rodent models |
| topic | <i>Sanghuangporus vaninii</i> <i>Inonotus hispidus</i> hyperuricemia gouty arthritis inflammation |
| url | https://www.mdpi.com/2072-6643/14/20/4421 |
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