The antioxidant and DNA-repair enzyme apurinic/apyrimidinic endonuclease 1 limits the development of tubulointerstitial fibrosis partly by modulating the immune system

The antioxidant and DNA-repair enzyme apurinic/apyrimidinic endonuclease 1 limits the development of tubulointerstitial fibrosis partly by modulating the immune system

Abstract Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein that controls the cellular response to oxidative stress and possesses DNA-repair functions. It has important roles in the progression and outcomes of various diseases; however, its function and therapeutic prospects wi...

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Bibliographic Details
Main Authors: Keisuke Maruyama, Naoki Nakagawa, Tatsuya Aonuma, Yukihiro Saito, Taiki Hayasaka, Kohei Kano, Kiwamu Horiuchi, Naofumi Takehara, Jun-ichi Kawabe, Naoyuki Hasebe
Format: Article
Language:English
Published: Nature Portfolio 2019-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-44241-z

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