Anti-CD20 Antibody and Calcineurin Inhibitor Combination Therapy Effectively Suppresses Antibody-Mediated Rejection in Murine Orthotopic Lung Transplantation

Anti-CD20 Antibody and Calcineurin Inhibitor Combination Therapy Effectively Suppresses Antibody-Mediated Rejection in Murine Orthotopic Lung Transplantation

Antibody-mediated rejection (AMR) is a risk factor for chronic lung allograft dysfunction, which impedes long-term survival after lung transplantation. There are no reports evaluating the efficacy of the single use of anti-CD20 antibodies (aCD20s) in addition to calcineurin inhibitors in preventing...

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Bibliographic Details
Main Authors: Hiroki Matsumoto, Hidemi Suzuki, Takahiro Yamanaka, Taisuke Kaiho, Atsushi Hata, Terunaga Inage, Takamasa Ito, Toshiko Kamata, Kazuhisa Tanaka, Yuichi Sakairi, Shinichiro Motohashi, Ichiro Yoshino
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Life
Subjects:
anti-CD20 antibodies
calcineurin inhibitors
antibody-mediated rejection
lung transplantation
donor specific antibodies
Online Access:https://www.mdpi.com/2075-1729/13/10/2042

Internet

https://www.mdpi.com/2075-1729/13/10/2042

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