The impact of pimavanserin on psychotic phenotypes and tau phosphorylation in the P301L/COMT– and rTg(P301L)4510 mouse models of Alzheimer's disease

The impact of pimavanserin on psychotic phenotypes and tau phosphorylation in the P301L/COMT– and rTg(P301L)4510 mouse models of Alzheimer's disease

Abstract Introduction Psychosis in Alzheimer's disease (AD) is associated with grave clinical consequences including a precipitous cognitive decline and a hastened demise. These outcomes are aggravated by use of existing antipsychotic medications, which are also associated with cognitive declin...

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Bibliographic Details
Main Authors: Heidy Jimenez, Leslie Adrien, Adam Wolin, John Eun, Eric H. Chang, Ethan S. Burstein, Jesus Gomar, Peter Davies, Jeremy Koppel
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Alzheimer's disease
antipsychotic
dopamine
locomotion
prepulse inhibition
psychosis
Online Access:https://doi.org/10.1002/trc2.12247

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