Assessment of risk factors, and racial and ethnic differences in hepatocellular carcinoma
Abstract Despite improved screening and surveillance guidelines, significant race/ethnicity‐specific disparities in hepatocellular carcinoma (HCC) continue to exist and disproportionately affect minority and disadvantaged populations. This trend indicates that social determinants, genetic, and envir...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-06-01
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| Series: | JGH Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jgh3.12336 |
| _version_ | 1818574782926422016 |
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| author | Ramesh P Thylur Sanjit K Roy Anju Shrivastava Thomas A LaVeist Sharmila Shankar Rakesh K Srivastava |
| author_facet | Ramesh P Thylur Sanjit K Roy Anju Shrivastava Thomas A LaVeist Sharmila Shankar Rakesh K Srivastava |
| author_sort | Ramesh P Thylur |
| collection | DOAJ |
| description | Abstract Despite improved screening and surveillance guidelines, significant race/ethnicity‐specific disparities in hepatocellular carcinoma (HCC) continue to exist and disproportionately affect minority and disadvantaged populations. This trend indicates that social determinants, genetic, and environmental factors are driving the epidemic at the population level. Race and geography had independent associations with risk of mortality among patients with HCC. The present review discusses the risk factors and issues related to disparities in HCC. The underlying etiologies for these disparities are complex and multifactorial. Some of the risk factors for developing HCC include hepatitis B (HBV) and hepatitis C (HCV) viral infection, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, smoking and alcohol consumption. In addition, population genetics; socioeconomic and health care access; treatment and prevention differences; and genetic, behavioral, and biological influences can contribute to HCC. Acculturation of ethnic minorities, insurance status, and access to health care may further contribute to the observed disparities in HCC. By increasing awareness, better modalities for screening and surveillance, improving access to health care, and adapting targeted preventive and therapeutic interventions, disparities in HCC outcomes can be reduced or eliminated. |
| first_indexed | 2024-12-15T00:30:41Z |
| format | Article |
| id | doaj.art-aa598d78732341ba9e36cc241dc9627b |
| institution | Directory Open Access Journal |
| issn | 2397-9070 |
| language | English |
| last_indexed | 2024-12-15T00:30:41Z |
| publishDate | 2020-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj.art-aa598d78732341ba9e36cc241dc9627b2022-12-21T22:42:01ZengWileyJGH Open2397-90702020-06-014335135910.1002/jgh3.12336Assessment of risk factors, and racial and ethnic differences in hepatocellular carcinomaRamesh P Thylur0Sanjit K Roy1Anju Shrivastava2Thomas A LaVeist3Sharmila Shankar4Rakesh K Srivastava5Stanley S. Scott Cancer Center Louisiana State University Health‐New Orleans School of Medicine New Orleans Louisiana USAStanley S. Scott Cancer Center Louisiana State University Health‐New Orleans School of Medicine New Orleans Louisiana USASt. Joseph's Hospital and Medical Center Phoenix Arizona USADepartment of Health Policy and Management Tulane University School of Public Health and Tropical Medicine New Orleans Louisiana USAStanley S. Scott Cancer Center Louisiana State University Health‐New Orleans School of Medicine New Orleans Louisiana USAStanley S. Scott Cancer Center Louisiana State University Health‐New Orleans School of Medicine New Orleans Louisiana USAAbstract Despite improved screening and surveillance guidelines, significant race/ethnicity‐specific disparities in hepatocellular carcinoma (HCC) continue to exist and disproportionately affect minority and disadvantaged populations. This trend indicates that social determinants, genetic, and environmental factors are driving the epidemic at the population level. Race and geography had independent associations with risk of mortality among patients with HCC. The present review discusses the risk factors and issues related to disparities in HCC. The underlying etiologies for these disparities are complex and multifactorial. Some of the risk factors for developing HCC include hepatitis B (HBV) and hepatitis C (HCV) viral infection, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, smoking and alcohol consumption. In addition, population genetics; socioeconomic and health care access; treatment and prevention differences; and genetic, behavioral, and biological influences can contribute to HCC. Acculturation of ethnic minorities, insurance status, and access to health care may further contribute to the observed disparities in HCC. By increasing awareness, better modalities for screening and surveillance, improving access to health care, and adapting targeted preventive and therapeutic interventions, disparities in HCC outcomes can be reduced or eliminated.https://doi.org/10.1002/jgh3.12336alcohol intakediabetesethnic disparitieshepatitis B (HBV) infectionhepatitis C (HCV) infectionhepatocellular carcinoma |
| spellingShingle | Ramesh P Thylur Sanjit K Roy Anju Shrivastava Thomas A LaVeist Sharmila Shankar Rakesh K Srivastava Assessment of risk factors, and racial and ethnic differences in hepatocellular carcinoma JGH Open alcohol intake diabetes ethnic disparities hepatitis B (HBV) infection hepatitis C (HCV) infection hepatocellular carcinoma |
| title | Assessment of risk factors, and racial and ethnic differences in hepatocellular carcinoma |
| title_full | Assessment of risk factors, and racial and ethnic differences in hepatocellular carcinoma |
| title_fullStr | Assessment of risk factors, and racial and ethnic differences in hepatocellular carcinoma |
| title_full_unstemmed | Assessment of risk factors, and racial and ethnic differences in hepatocellular carcinoma |
| title_short | Assessment of risk factors, and racial and ethnic differences in hepatocellular carcinoma |
| title_sort | assessment of risk factors and racial and ethnic differences in hepatocellular carcinoma |
| topic | alcohol intake diabetes ethnic disparities hepatitis B (HBV) infection hepatitis C (HCV) infection hepatocellular carcinoma |
| url | https://doi.org/10.1002/jgh3.12336 |
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