Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation
ESCRT-III complexes assemble in vivo inside membrane structures with a negative Gaussian curvature, but how membrane shape influences ESCRT-III polymerization remains unclear. Here authors use structural and biophysical methods to show how human ESCRT-III polymers assemble on positively curved membr...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16368-5 |
| _version_ | 1818843422417485824 |
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| author | Aurélie Bertin Nicola de Franceschi Eugenio de la Mora Sourav Maity Maryam Alqabandi Nolwen Miguet Aurélie di Cicco Wouter H. Roos Stéphanie Mangenot Winfried Weissenhorn Patricia Bassereau |
| author_facet | Aurélie Bertin Nicola de Franceschi Eugenio de la Mora Sourav Maity Maryam Alqabandi Nolwen Miguet Aurélie di Cicco Wouter H. Roos Stéphanie Mangenot Winfried Weissenhorn Patricia Bassereau |
| author_sort | Aurélie Bertin |
| collection | DOAJ |
| description | ESCRT-III complexes assemble in vivo inside membrane structures with a negative Gaussian curvature, but how membrane shape influences ESCRT-III polymerization remains unclear. Here authors use structural and biophysical methods to show how human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation. |
| first_indexed | 2024-12-19T04:57:37Z |
| format | Article |
| id | doaj.art-aa5a1cbf4c8c4f8ebe1df35bf137441a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:57:37Z |
| publishDate | 2020-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-aa5a1cbf4c8c4f8ebe1df35bf137441a2022-12-21T20:35:11ZengNature PortfolioNature Communications2041-17232020-05-0111111310.1038/s41467-020-16368-5Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formationAurélie Bertin0Nicola de Franceschi1Eugenio de la Mora2Sourav Maity3Maryam Alqabandi4Nolwen Miguet5Aurélie di Cicco6Wouter H. Roos7Stéphanie Mangenot8Winfried Weissenhorn9Patricia Bassereau10Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Nijenborgh 4Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS), 71, avenue des MartyrsLaboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Nijenborgh 4Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS), 71, avenue des MartyrsLaboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168ESCRT-III complexes assemble in vivo inside membrane structures with a negative Gaussian curvature, but how membrane shape influences ESCRT-III polymerization remains unclear. Here authors use structural and biophysical methods to show how human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation.https://doi.org/10.1038/s41467-020-16368-5 |
| spellingShingle | Aurélie Bertin Nicola de Franceschi Eugenio de la Mora Sourav Maity Maryam Alqabandi Nolwen Miguet Aurélie di Cicco Wouter H. Roos Stéphanie Mangenot Winfried Weissenhorn Patricia Bassereau Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation Nature Communications |
| title | Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation |
| title_full | Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation |
| title_fullStr | Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation |
| title_full_unstemmed | Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation |
| title_short | Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation |
| title_sort | human escrt iii polymers assemble on positively curved membranes and induce helical membrane tube formation |
| url | https://doi.org/10.1038/s41467-020-16368-5 |
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