Preclinical cardiac disease in women and men with primary aldosteronism
Purpose We tested the sex-specific associations between primary aldosteronism (PA), left ventricular (LV) hypertrophy and LV systolic myocardial function. Material and methods Conventional and speckle tracking echocardiography was performed in 109 patients with PA and 89 controls with essential hype...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-07-01
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| Series: | Blood Pressure |
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| Online Access: | http://dx.doi.org/10.1080/08037051.2021.1904775 |
| _version_ | 1797685096711454720 |
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| author | Arleen Aune Marina Kokorina Marianne Aa. Grytaas Helga Midtbø Kristian Løvås Eva Gerdts |
| author_facet | Arleen Aune Marina Kokorina Marianne Aa. Grytaas Helga Midtbø Kristian Løvås Eva Gerdts |
| author_sort | Arleen Aune |
| collection | DOAJ |
| description | Purpose We tested the sex-specific associations between primary aldosteronism (PA), left ventricular (LV) hypertrophy and LV systolic myocardial function. Material and methods Conventional and speckle tracking echocardiography was performed in 109 patients with PA and 89 controls with essential hypertension (EH). LV hypertrophy was identified if LV mass index exceeded 47.0 g/m2.7 in women and 50.0 g/m2.7 in men. LV systolic myocardial function was assessed by global longitudinal strain (GLS) and midwall shortening. Results PA patients had higher prevalence of LV hypertrophy (52 vs. 21%, p < 0.001) than EH patients in both sexes, while GLS did not differ by sex or hypertension aetiology. In multivariable analyses, presence of LV hypertrophy was associated with PA and obesity in both sexes, while lower systolic myocardial function, whether measured by GLS or midwall shortening, was not associated with PA, but primarily with higher body mass index and LV mass index, respectively, in both sexes (all p < 0.05). Conclusion Having PA was associated with higher prevalence of LV hypertrophy both in women and men, compared to EH. PA was not associated with LV systolic myocardial function in either sex. |
| first_indexed | 2024-03-12T00:39:23Z |
| format | Article |
| id | doaj.art-aa5c146261fe4352aeb67890abbce7f4 |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-12T00:39:23Z |
| publishDate | 2021-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-aa5c146261fe4352aeb67890abbce7f42023-09-15T08:45:24ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992021-07-0130423023610.1080/08037051.2021.19047751904775Preclinical cardiac disease in women and men with primary aldosteronismArleen Aune0Marina Kokorina1Marianne Aa. Grytaas2Helga Midtbø3Kristian Løvås4Eva Gerdts5Department of Clinical Science, University of BergenDepartment of Heart Disease, Haukeland University HospitalDepartment of Medicine, Haukeland University HospitalDepartment of Heart Disease, Haukeland University HospitalDepartment of Medicine, Haukeland University HospitalDepartment of Clinical Science, University of BergenPurpose We tested the sex-specific associations between primary aldosteronism (PA), left ventricular (LV) hypertrophy and LV systolic myocardial function. Material and methods Conventional and speckle tracking echocardiography was performed in 109 patients with PA and 89 controls with essential hypertension (EH). LV hypertrophy was identified if LV mass index exceeded 47.0 g/m2.7 in women and 50.0 g/m2.7 in men. LV systolic myocardial function was assessed by global longitudinal strain (GLS) and midwall shortening. Results PA patients had higher prevalence of LV hypertrophy (52 vs. 21%, p < 0.001) than EH patients in both sexes, while GLS did not differ by sex or hypertension aetiology. In multivariable analyses, presence of LV hypertrophy was associated with PA and obesity in both sexes, while lower systolic myocardial function, whether measured by GLS or midwall shortening, was not associated with PA, but primarily with higher body mass index and LV mass index, respectively, in both sexes (all p < 0.05). Conclusion Having PA was associated with higher prevalence of LV hypertrophy both in women and men, compared to EH. PA was not associated with LV systolic myocardial function in either sex.http://dx.doi.org/10.1080/08037051.2021.1904775primary aldosteronismhypertensionsexleft ventricular hypertrophyglobal longitudinal strainmidwall shortening |
| spellingShingle | Arleen Aune Marina Kokorina Marianne Aa. Grytaas Helga Midtbø Kristian Løvås Eva Gerdts Preclinical cardiac disease in women and men with primary aldosteronism Blood Pressure primary aldosteronism hypertension sex left ventricular hypertrophy global longitudinal strain midwall shortening |
| title | Preclinical cardiac disease in women and men with primary aldosteronism |
| title_full | Preclinical cardiac disease in women and men with primary aldosteronism |
| title_fullStr | Preclinical cardiac disease in women and men with primary aldosteronism |
| title_full_unstemmed | Preclinical cardiac disease in women and men with primary aldosteronism |
| title_short | Preclinical cardiac disease in women and men with primary aldosteronism |
| title_sort | preclinical cardiac disease in women and men with primary aldosteronism |
| topic | primary aldosteronism hypertension sex left ventricular hypertrophy global longitudinal strain midwall shortening |
| url | http://dx.doi.org/10.1080/08037051.2021.1904775 |
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