Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project
Objective It is debatable whether BCR-ABL1 transcript type has an impact on outcome of treatment of patients with CML, and it is not widely studied whether body weight influences response to treatment. In this study, we tried to find out if any of these factors has an impact on response to treatment...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-08-01
|
| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/10732748211038429 |
| _version_ | 1819006460283060224 |
|---|---|
| author | Mohammad A. J. Abdulla MD Prem Chandra PhD Susanna El Akiki PhD Mahmood B. Aldapt MD Sundus Sardar MBBS Ammar Chapra MBBS Abdulqadir J. Nashwan MSC Claudio Sorio MD, PhD Luisa Tomasello PhD Christian Boni PhD Mohamed A. Yassin MBBS, CABM MSC, FACP MSC |
| author_facet | Mohammad A. J. Abdulla MD Prem Chandra PhD Susanna El Akiki PhD Mahmood B. Aldapt MD Sundus Sardar MBBS Ammar Chapra MBBS Abdulqadir J. Nashwan MSC Claudio Sorio MD, PhD Luisa Tomasello PhD Christian Boni PhD Mohamed A. Yassin MBBS, CABM MSC, FACP MSC |
| author_sort | Mohammad A. J. Abdulla MD |
| collection | DOAJ |
| description | Objective It is debatable whether BCR-ABL1 transcript type has an impact on outcome of treatment of patients with CML, and it is not widely studied whether body weight influences response to treatment. In this study, we tried to find out if any of these factors has an impact on response to treatment and outcome. Methodology We conducted a retrospective analysis of the files of 79 patients being treated in our center for CML with known BCR-ABL1 breakpoints, and patients’ management and response assessment was done based on ELN 2013 guidelines. The analysis was performed based on two main groups, obese vs. normal BMI, and then based on BCR-ABL1 transcripts: e13a2 vs. e14a2. Cumulative incidence of MMR, CCyR, and DMR were estimated using the Kaplan–Meier survival curve method, and comparisons between groups were performed by the Log-rank/Gray test methods. Results/conclusion In the patient-cohort studied, there was no statistically significant difference in molecular response between patients with CML based on body weight or transcript type although patients in the obesity group achieved higher and faster MMR with no statistical significance. |
| first_indexed | 2024-12-21T00:09:02Z |
| format | Article |
| id | doaj.art-aa6096a507c045d9acd9a0fc42e59864 |
| institution | Directory Open Access Journal |
| issn | 1073-2748 |
| language | English |
| last_indexed | 2024-12-21T00:09:02Z |
| publishDate | 2021-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-aa6096a507c045d9acd9a0fc42e598642022-12-21T19:22:24ZengSAGE PublishingCancer Control1073-27482021-08-012810.1177/10732748211038429Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet ProjectMohammad A. J. Abdulla MDPrem Chandra PhDSusanna El Akiki PhDMahmood B. Aldapt MDSundus Sardar MBBSAmmar Chapra MBBSAbdulqadir J. Nashwan MSCClaudio Sorio MD, PhDLuisa Tomasello PhDChristian Boni PhDMohamed A. Yassin MBBS, CABM MSC, FACP MSCObjective It is debatable whether BCR-ABL1 transcript type has an impact on outcome of treatment of patients with CML, and it is not widely studied whether body weight influences response to treatment. In this study, we tried to find out if any of these factors has an impact on response to treatment and outcome. Methodology We conducted a retrospective analysis of the files of 79 patients being treated in our center for CML with known BCR-ABL1 breakpoints, and patients’ management and response assessment was done based on ELN 2013 guidelines. The analysis was performed based on two main groups, obese vs. normal BMI, and then based on BCR-ABL1 transcripts: e13a2 vs. e14a2. Cumulative incidence of MMR, CCyR, and DMR were estimated using the Kaplan–Meier survival curve method, and comparisons between groups were performed by the Log-rank/Gray test methods. Results/conclusion In the patient-cohort studied, there was no statistically significant difference in molecular response between patients with CML based on body weight or transcript type although patients in the obesity group achieved higher and faster MMR with no statistical significance.https://doi.org/10.1177/10732748211038429 |
| spellingShingle | Mohammad A. J. Abdulla MD Prem Chandra PhD Susanna El Akiki PhD Mahmood B. Aldapt MD Sundus Sardar MBBS Ammar Chapra MBBS Abdulqadir J. Nashwan MSC Claudio Sorio MD, PhD Luisa Tomasello PhD Christian Boni PhD Mohamed A. Yassin MBBS, CABM MSC, FACP MSC Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project Cancer Control |
| title | Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project |
| title_full | Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project |
| title_fullStr | Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project |
| title_full_unstemmed | Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project |
| title_short | Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project |
| title_sort | clinicopathological variables and outcome in chronic myeloid leukemia associated with bcr abl1 transcript type and body weight an outcome of european leukemianet project |
| url | https://doi.org/10.1177/10732748211038429 |
| work_keys_str_mv | AT mohammadajabdullamd clinicopathologicalvariablesandoutcomeinchronicmyeloidleukemiaassociatedwithbcrabl1transcripttypeandbodyweightanoutcomeofeuropeanleukemianetproject AT premchandraphd clinicopathologicalvariablesandoutcomeinchronicmyeloidleukemiaassociatedwithbcrabl1transcripttypeandbodyweightanoutcomeofeuropeanleukemianetproject AT susannaelakikiphd clinicopathologicalvariablesandoutcomeinchronicmyeloidleukemiaassociatedwithbcrabl1transcripttypeandbodyweightanoutcomeofeuropeanleukemianetproject AT mahmoodbaldaptmd clinicopathologicalvariablesandoutcomeinchronicmyeloidleukemiaassociatedwithbcrabl1transcripttypeandbodyweightanoutcomeofeuropeanleukemianetproject AT sundussardarmbbs clinicopathologicalvariablesandoutcomeinchronicmyeloidleukemiaassociatedwithbcrabl1transcripttypeandbodyweightanoutcomeofeuropeanleukemianetproject AT ammarchaprambbs clinicopathologicalvariablesandoutcomeinchronicmyeloidleukemiaassociatedwithbcrabl1transcripttypeandbodyweightanoutcomeofeuropeanleukemianetproject AT abdulqadirjnashwanmsc clinicopathologicalvariablesandoutcomeinchronicmyeloidleukemiaassociatedwithbcrabl1transcripttypeandbodyweightanoutcomeofeuropeanleukemianetproject AT claudiosoriomdphd clinicopathologicalvariablesandoutcomeinchronicmyeloidleukemiaassociatedwithbcrabl1transcripttypeandbodyweightanoutcomeofeuropeanleukemianetproject AT luisatomasellophd clinicopathologicalvariablesandoutcomeinchronicmyeloidleukemiaassociatedwithbcrabl1transcripttypeandbodyweightanoutcomeofeuropeanleukemianetproject AT christianboniphd clinicopathologicalvariablesandoutcomeinchronicmyeloidleukemiaassociatedwithbcrabl1transcripttypeandbodyweightanoutcomeofeuropeanleukemianetproject AT mohamedayassinmbbscabmmscfacpmsc clinicopathologicalvariablesandoutcomeinchronicmyeloidleukemiaassociatedwithbcrabl1transcripttypeandbodyweightanoutcomeofeuropeanleukemianetproject |