Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study
Abstract Background We aimed to explore the prognostic utilities of C-reactive protein (CRP), procalcitonin (PCT), neutrophil CD64 (nCD64) index, in combination or alone, in septic patients. Methods We retrospectively included 349 septic patients (based on Sepsis 3.0 definition). The primary outcome...
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-022-07650-6 |
| _version_ | 1818162806542827520 |
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| author | Na Huang Jing Chen Yu Wei Yongrui Liu Kang Yuan Jingli Chen Mingfeng He Nan Liu |
| author_facet | Na Huang Jing Chen Yu Wei Yongrui Liu Kang Yuan Jingli Chen Mingfeng He Nan Liu |
| author_sort | Na Huang |
| collection | DOAJ |
| description | Abstract Background We aimed to explore the prognostic utilities of C-reactive protein (CRP), procalcitonin (PCT), neutrophil CD64 (nCD64) index, in combination or alone, in septic patients. Methods We retrospectively included 349 septic patients (based on Sepsis 3.0 definition). The primary outcome was 28-day all-cause mortality. Cox regression model, receiver-operating characteristic (ROC) curve, reclassification analysis, Kaplan–Meier survival curves were performed to evaluate the predictive efficacy of the above parameters. Results CRP, nCD64 index were independent predictors of 28-day mortality for sepsis in the Cox regression model [CRP, HR 1.004 (95% CI 1.002–1.006), P < 0.001; nCD64 index, HR 1.263 (95% CI 1.187–1.345, P < 0.001]. Area under the ROC curve (AUC) of CRP, PCT, nCD64 index, nCD64 index plus PCT, nCD64 index plus CRP, were 0.798 (95% CI 0.752–0.839), 0.833 (95% CI 0.790–0.871), 0.906 (95% CI 0.870–0.935), 0.910 (95% CI 0.875–0.938), 0.916 (95% CI 0.881–0.943), respectively. nCD64 plus CRP performed best in prediction, discrimination, and reclassification of the 28-day mortality risk in sepsis. The risk of 28-day mortality increased stepwise as the number of data exceeding optimal cut-off values increased. Conclusions nCD64 index combined with CRP was superior to CRP, PCT, nCD64 index and nCD64 index plus PCT in predicting 28-day mortality in sepsis. Multi-marker approach could improve the predictive accuracy and be beneficial for septic patients. |
| first_indexed | 2024-12-11T16:39:31Z |
| format | Article |
| id | doaj.art-aa61c11ab0744ccc9116ba82c5df8d3c |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-11T16:39:31Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-aa61c11ab0744ccc9116ba82c5df8d3c2022-12-22T00:58:22ZengBMCBMC Infectious Diseases1471-23342022-07-012211810.1186/s12879-022-07650-6Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort studyNa Huang0Jing Chen1Yu Wei2Yongrui Liu3Kang Yuan4Jingli Chen5Mingfeng He6Nan Liu7Foshan Hospital of Traditional Chinese MedicineDepartment of Critical Care Medicine, The First Affiliated Hospital of GuangZhou University of Chinese MedicineBasic Medical College, Guangzhou University of Chinese MedicineEmergency Department, The First Affiliated Hospital of GuangZhou University of Chinese MedicineEmergency Department, Foshan Hospital of Traditional Chinese MedicineEmergency Department, Foshan Hospital of Traditional Chinese MedicineFoshan Hospital of Traditional Chinese MedicineEmergency Department, The First Affiliated Hospital of GuangZhou University of Chinese MedicineAbstract Background We aimed to explore the prognostic utilities of C-reactive protein (CRP), procalcitonin (PCT), neutrophil CD64 (nCD64) index, in combination or alone, in septic patients. Methods We retrospectively included 349 septic patients (based on Sepsis 3.0 definition). The primary outcome was 28-day all-cause mortality. Cox regression model, receiver-operating characteristic (ROC) curve, reclassification analysis, Kaplan–Meier survival curves were performed to evaluate the predictive efficacy of the above parameters. Results CRP, nCD64 index were independent predictors of 28-day mortality for sepsis in the Cox regression model [CRP, HR 1.004 (95% CI 1.002–1.006), P < 0.001; nCD64 index, HR 1.263 (95% CI 1.187–1.345, P < 0.001]. Area under the ROC curve (AUC) of CRP, PCT, nCD64 index, nCD64 index plus PCT, nCD64 index plus CRP, were 0.798 (95% CI 0.752–0.839), 0.833 (95% CI 0.790–0.871), 0.906 (95% CI 0.870–0.935), 0.910 (95% CI 0.875–0.938), 0.916 (95% CI 0.881–0.943), respectively. nCD64 plus CRP performed best in prediction, discrimination, and reclassification of the 28-day mortality risk in sepsis. The risk of 28-day mortality increased stepwise as the number of data exceeding optimal cut-off values increased. Conclusions nCD64 index combined with CRP was superior to CRP, PCT, nCD64 index and nCD64 index plus PCT in predicting 28-day mortality in sepsis. Multi-marker approach could improve the predictive accuracy and be beneficial for septic patients.https://doi.org/10.1186/s12879-022-07650-6SepsisPrognosisC-reactive proteinProcalcitoninNeutrophil CD64 index |
| spellingShingle | Na Huang Jing Chen Yu Wei Yongrui Liu Kang Yuan Jingli Chen Mingfeng He Nan Liu Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study BMC Infectious Diseases Sepsis Prognosis C-reactive protein Procalcitonin Neutrophil CD64 index |
| title | Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study |
| title_full | Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study |
| title_fullStr | Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study |
| title_full_unstemmed | Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study |
| title_short | Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study |
| title_sort | multi marker approach using c reactive protein procalcitonin neutrophil cd64 index for the prognosis of sepsis in intensive care unit a retrospective cohort study |
| topic | Sepsis Prognosis C-reactive protein Procalcitonin Neutrophil CD64 index |
| url | https://doi.org/10.1186/s12879-022-07650-6 |
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