Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage
Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00483/full |
| _version_ | 1811338147452157952 |
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| author | Martín Bustelo Martín Bustelo Martín Bustelo Martín Bustelo Melinda Barkhuizen Daniel L. A. van den Hove Daniel L. A. van den Hove Harry Wilhelm. M. Steinbusch Martín A. Bruno C. Fabián Loidl C. Fabián Loidl Antonio W. Danilo Gavilanes Antonio W. Danilo Gavilanes |
| author_facet | Martín Bustelo Martín Bustelo Martín Bustelo Martín Bustelo Melinda Barkhuizen Daniel L. A. van den Hove Daniel L. A. van den Hove Harry Wilhelm. M. Steinbusch Martín A. Bruno C. Fabián Loidl C. Fabián Loidl Antonio W. Danilo Gavilanes Antonio W. Danilo Gavilanes |
| author_sort | Martín Bustelo |
| collection | DOAJ |
| description | Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation, are associated with lasting disruptions in epigenetic control of gene expression contributing to neurological dysfunction. Recent studies have pointed to DNA (de)methylation, histone modifications, and non-coding RNAs as crucial components of hypoxic-ischemic encephalopathy (HIE). The understanding of epigenetic dysregulation in HIE is essential in the development of new clinical interventions for perinatal HIE. Here, we summarize our current understanding of epigenetic mechanisms underlying the molecular pathology of HI brain damage and its clinical implications in terms of new diagnostic, prognostic, and therapeutic tools. |
| first_indexed | 2024-04-13T18:05:39Z |
| format | Article |
| id | doaj.art-aa6396ab6215439b8a34900cd1e0986c |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T18:05:39Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-aa6396ab6215439b8a34900cd1e0986c2022-12-22T02:36:04ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-06-011110.3389/fneur.2020.00483514117Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain DamageMartín Bustelo0Martín Bustelo1Martín Bustelo2Martín Bustelo3Melinda Barkhuizen4Daniel L. A. van den Hove5Daniel L. A. van den Hove6Harry Wilhelm. M. Steinbusch7Martín A. Bruno8C. Fabián Loidl9C. Fabián Loidl10Antonio W. Danilo Gavilanes11Antonio W. Danilo Gavilanes12Department of Pediatrics, Maastricht University Medical Center (MUMC), Maastricht, NetherlandsDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, NetherlandsInstituto de Ciencias Biomédicas, Facultad de Ciencias Médicas, Universidad Católica de Cuyo, San Juan, ArgentinaLaboratorio de Neuropatología Experimental, Facultad de Medicina, Instituto de Biología Celular y Neurociencias “Prof. E. De Robertis” (IBCN), Universidad de Buenos Aires, CONICET, Buenos Aires, ArgentinaDepartment of Pediatrics, Maastricht University Medical Center (MUMC), Maastricht, NetherlandsDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, NetherlandsDepartment of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, GermanyDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, NetherlandsInstituto de Ciencias Biomédicas, Facultad de Ciencias Médicas, Universidad Católica de Cuyo, San Juan, ArgentinaInstituto de Ciencias Biomédicas, Facultad de Ciencias Médicas, Universidad Católica de Cuyo, San Juan, ArgentinaLaboratorio de Neuropatología Experimental, Facultad de Medicina, Instituto de Biología Celular y Neurociencias “Prof. E. De Robertis” (IBCN), Universidad de Buenos Aires, CONICET, Buenos Aires, ArgentinaDepartment of Pediatrics, Maastricht University Medical Center (MUMC), Maastricht, NetherlandsFacultad de Ciencias Médicas, Instituto de Investigación e Innovación de Salud Integral, Universidad Católica de Santiago de Guayaquil, Guayaquil, EcuadorPlacental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation, are associated with lasting disruptions in epigenetic control of gene expression contributing to neurological dysfunction. Recent studies have pointed to DNA (de)methylation, histone modifications, and non-coding RNAs as crucial components of hypoxic-ischemic encephalopathy (HIE). The understanding of epigenetic dysregulation in HIE is essential in the development of new clinical interventions for perinatal HIE. Here, we summarize our current understanding of epigenetic mechanisms underlying the molecular pathology of HI brain damage and its clinical implications in terms of new diagnostic, prognostic, and therapeutic tools.https://www.frontiersin.org/article/10.3389/fneur.2020.00483/fullhypoxic-ischemic encephalopathybiomarkerhypoxiaischemiamicroRNAshistone modifications |
| spellingShingle | Martín Bustelo Martín Bustelo Martín Bustelo Martín Bustelo Melinda Barkhuizen Daniel L. A. van den Hove Daniel L. A. van den Hove Harry Wilhelm. M. Steinbusch Martín A. Bruno C. Fabián Loidl C. Fabián Loidl Antonio W. Danilo Gavilanes Antonio W. Danilo Gavilanes Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage Frontiers in Neurology hypoxic-ischemic encephalopathy biomarker hypoxia ischemia microRNAs histone modifications |
| title | Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
| title_full | Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
| title_fullStr | Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
| title_full_unstemmed | Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
| title_short | Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
| title_sort | clinical implications of epigenetic dysregulation in perinatal hypoxic ischemic brain damage |
| topic | hypoxic-ischemic encephalopathy biomarker hypoxia ischemia microRNAs histone modifications |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00483/full |
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