CD169+ macrophages orchestrate plasmacytoid dendritic cell arrest and retention for optimal priming in the bone marrow of malaria-infected mice

CD169+ macrophages orchestrate plasmacytoid dendritic cell arrest and retention for optimal priming in the bone marrow of malaria-infected mice

Plasmacytoid dendritic cells (pDCs) are the most potent producer of type I interferon (IFN), but how pDC is primed in vivo is poorly defined. Using a mouse model of severe malaria, we have previously established that upon priming by CD169+ macrophages (MPs), pDC initiates type I IFN-I secretion in t...

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Bibliographic Details
Main Authors: Jamie Moore-Fried, Mahinder Paul, Zhixin Jing, David Fooksman, Gregoire Lauvau
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
plasmacytoid dendritic cell
CD169+ macrophage
severe malaria
type I interferon
intravital imaging
bone marrow
Online Access:https://elifesciences.org/articles/78873

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