Plasma nitric oxide in dogs with pulmonary hypertension secondary or not to left-sided heart disease
ABSTRACT Nitric oxide (NO) is an important mediator responsible for vasodilation in pulmonary hypertension (PH) in humans. Based on human literature, it is suggested that in dogs there is also NO production decrease in lung tissue in the presence of PH with hypoxia. Therefore, the aim of this resear...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade Federal de Minas Gerais
2023-04-01
|
| Series: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352023000200161&lng=en&tlng=en |
| _version_ | 1797844882885181440 |
|---|---|
| author | J.B. Braz T. Beluque R.A.N. Ampuero R.A.M. Canola M..E. Batalhão E.C. Cárnio A.A. Camacho |
| author_facet | J.B. Braz T. Beluque R.A.N. Ampuero R.A.M. Canola M..E. Batalhão E.C. Cárnio A.A. Camacho |
| author_sort | J.B. Braz |
| collection | DOAJ |
| description | ABSTRACT Nitric oxide (NO) is an important mediator responsible for vasodilation in pulmonary hypertension (PH) in humans. Based on human literature, it is suggested that in dogs there is also NO production decrease in lung tissue in the presence of PH with hypoxia. Therefore, the aim of this research was to determine the indirect plasmatic NO concentration in dogs with PH secondary or not to the left-side heart disease (LHD) and also with low, intermediate and high probability of PH to characterize the NO involvement on PH in dogs. Blood samples were collected from 35 dogs with probability of PH to NO measurement. NO concentration was estimated by the nitrite/nitrate concentration, and it was significantly different (p=0.002) in dogs with PH secondary to LHD (median=14 µM, range 11.19-16.59) and not secondary to LHD (median=25.88µM, range 15.08-36.71). However, this was not significant for the probability of low, intermediate, and high PH, although there was a tendency for NO concentration to be higher in dogs with high PH. The results of this study demonstrate that there is release of NO in dogs with PH, as well as that its dosage could differentiate dogs with PH secondary to LHD from dogs with non-secondary PH. |
| first_indexed | 2024-04-09T17:29:34Z |
| format | Article |
| id | doaj.art-aa6586c1f2364215b76975816e62fcd4 |
| institution | Directory Open Access Journal |
| issn | 1678-4162 |
| language | English |
| last_indexed | 2024-04-09T17:29:34Z |
| publishDate | 2023-04-01 |
| publisher | Universidade Federal de Minas Gerais |
| record_format | Article |
| series | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| spelling | doaj.art-aa6586c1f2364215b76975816e62fcd42023-04-18T07:33:34ZengUniversidade Federal de Minas GeraisArquivo Brasileiro de Medicina Veterinária e Zootecnia1678-41622023-04-0175216117310.1590/1678-4162-12528Plasma nitric oxide in dogs with pulmonary hypertension secondary or not to left-sided heart diseaseJ.B. Brazhttps://orcid.org/0000-0002-4269-8932T. Beluquehttps://orcid.org/0000-0003-2858-0310R.A.N. Ampuerohttps://orcid.org/0000-0002-9135-9769R.A.M. Canolahttps://orcid.org/0000-0001-5629-013XM..E. Batalhãohttps://orcid.org/0000-0003-3342-6625E.C. Cárniohttps://orcid.org/0000-0002-8735-4252A.A. Camachohttps://orcid.org/0000-0001-9802-9271ABSTRACT Nitric oxide (NO) is an important mediator responsible for vasodilation in pulmonary hypertension (PH) in humans. Based on human literature, it is suggested that in dogs there is also NO production decrease in lung tissue in the presence of PH with hypoxia. Therefore, the aim of this research was to determine the indirect plasmatic NO concentration in dogs with PH secondary or not to the left-side heart disease (LHD) and also with low, intermediate and high probability of PH to characterize the NO involvement on PH in dogs. Blood samples were collected from 35 dogs with probability of PH to NO measurement. NO concentration was estimated by the nitrite/nitrate concentration, and it was significantly different (p=0.002) in dogs with PH secondary to LHD (median=14 µM, range 11.19-16.59) and not secondary to LHD (median=25.88µM, range 15.08-36.71). However, this was not significant for the probability of low, intermediate, and high PH, although there was a tendency for NO concentration to be higher in dogs with high PH. The results of this study demonstrate that there is release of NO in dogs with PH, as well as that its dosage could differentiate dogs with PH secondary to LHD from dogs with non-secondary PH.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352023000200161&lng=en&tlng=enhypoxianitratenitritepulmonary arterial pressurepulmonary vasculature |
| spellingShingle | J.B. Braz T. Beluque R.A.N. Ampuero R.A.M. Canola M..E. Batalhão E.C. Cárnio A.A. Camacho Plasma nitric oxide in dogs with pulmonary hypertension secondary or not to left-sided heart disease Arquivo Brasileiro de Medicina Veterinária e Zootecnia hypoxia nitrate nitrite pulmonary arterial pressure pulmonary vasculature |
| title | Plasma nitric oxide in dogs with pulmonary hypertension secondary or not to left-sided heart disease |
| title_full | Plasma nitric oxide in dogs with pulmonary hypertension secondary or not to left-sided heart disease |
| title_fullStr | Plasma nitric oxide in dogs with pulmonary hypertension secondary or not to left-sided heart disease |
| title_full_unstemmed | Plasma nitric oxide in dogs with pulmonary hypertension secondary or not to left-sided heart disease |
| title_short | Plasma nitric oxide in dogs with pulmonary hypertension secondary or not to left-sided heart disease |
| title_sort | plasma nitric oxide in dogs with pulmonary hypertension secondary or not to left sided heart disease |
| topic | hypoxia nitrate nitrite pulmonary arterial pressure pulmonary vasculature |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352023000200161&lng=en&tlng=en |
| work_keys_str_mv | AT jbbraz plasmanitricoxideindogswithpulmonaryhypertensionsecondaryornottoleftsidedheartdisease AT tbeluque plasmanitricoxideindogswithpulmonaryhypertensionsecondaryornottoleftsidedheartdisease AT ranampuero plasmanitricoxideindogswithpulmonaryhypertensionsecondaryornottoleftsidedheartdisease AT ramcanola plasmanitricoxideindogswithpulmonaryhypertensionsecondaryornottoleftsidedheartdisease AT mebatalhao plasmanitricoxideindogswithpulmonaryhypertensionsecondaryornottoleftsidedheartdisease AT eccarnio plasmanitricoxideindogswithpulmonaryhypertensionsecondaryornottoleftsidedheartdisease AT aacamacho plasmanitricoxideindogswithpulmonaryhypertensionsecondaryornottoleftsidedheartdisease |