Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation
Abstract Objective To investigate associations between body mass index (BMI), white matter fractional anisotropy (FA), and C-reactive protein (CRP) in a group of individuals with bipolar disorder (BD) during euthymia and compare them with a control group of healthy subjects (CTR). Methods The sa...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Associação de Psiquiatria do Rio Grande do Sul
2022-09-01
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| Series: | Trends in Psychiatry and Psychotherapy |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892022000100416&tlng=en |
| _version_ | 1798001366460792832 |
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| author | Ramiro Reckziegel Francisco Diego Rabelo-da-Ponte Jacson Gabriel Feiten Isadora Bosini Remus Pedro Domingues Goi Miréia Fortes Vianna-Sulzbach Raffael Massuda Danielle Macedo David de Lucena Letícia Sanguinetti Czepielewski Clarissa Severino Gama |
| author_facet | Ramiro Reckziegel Francisco Diego Rabelo-da-Ponte Jacson Gabriel Feiten Isadora Bosini Remus Pedro Domingues Goi Miréia Fortes Vianna-Sulzbach Raffael Massuda Danielle Macedo David de Lucena Letícia Sanguinetti Czepielewski Clarissa Severino Gama |
| author_sort | Ramiro Reckziegel |
| collection | DOAJ |
| description | Abstract Objective To investigate associations between body mass index (BMI), white matter fractional anisotropy (FA), and C-reactive protein (CRP) in a group of individuals with bipolar disorder (BD) during euthymia and compare them with a control group of healthy subjects (CTR). Methods The sample consisted of 101 individuals (BD n = 35 and CTR n = 66). Regions of interest (ROI) were defined using a machine learning approach. For each ROI, a regression model tested the association between FA and BMI, controlling for covariates. Peripheral CRP levels were assayed, correlated with BMI, and included in a mediation analysis. Results BMI predicted the FA of the right cingulate gyrus in BD (AdjR2 = 0.312 F(3) = 5.537 p = 0.004; β = -0.340 p = 0.034), while there was no association in CTR. There was an interaction effect between BMI and BD diagnosis (F(5) = 3.5857 p = 0.012; Fchange = 0.227 AdjR2 = 0.093; β = -1.093, p = 0.048). Furthermore, there was a positive correlation between BMI and CRP in both groups (AdjR2 = 0.170 F(3) = 7.337 p < 0.001; β = 0.364 p = 0.001), but it did not act as a mediator of the effect on FA. Conclusion Higher BMI is associated with right cingulate microstructure in BD, but not in CTR, and this effect could not be explained by inflammatory mediation alone. |
| first_indexed | 2024-04-11T11:34:59Z |
| format | Article |
| id | doaj.art-aa66ec872d5240daae39a8a93e6f94db |
| institution | Directory Open Access Journal |
| issn | 2238-0019 |
| language | English |
| last_indexed | 2024-04-11T11:34:59Z |
| publishDate | 2022-09-01 |
| publisher | Associação de Psiquiatria do Rio Grande do Sul |
| record_format | Article |
| series | Trends in Psychiatry and Psychotherapy |
| spelling | doaj.art-aa66ec872d5240daae39a8a93e6f94db2022-12-22T04:26:00ZengAssociação de Psiquiatria do Rio Grande do SulTrends in Psychiatry and Psychotherapy2238-00192022-09-014410.47626/2237-6089-2020-0132Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammationRamiro Reckziegelhttps://orcid.org/0000-0003-0178-5834Francisco Diego Rabelo-da-Pontehttps://orcid.org/0000-0001-9016-2414Jacson Gabriel Feitenhttps://orcid.org/0000-0003-0414-6421Isadora Bosini Remushttps://orcid.org/0000-0003-1541-7039Pedro Domingues Goihttps://orcid.org/0000-0001-7666-1241Miréia Fortes Vianna-Sulzbachhttps://orcid.org/0000-0003-3547-1112Raffael Massudahttps://orcid.org/0000-0002-2627-8022Danielle Macedohttps://orcid.org/0000-0001-8980-9970David de Lucenahttps://orcid.org/0000-0002-1547-3711Letícia Sanguinetti Czepielewskihttps://orcid.org/0000-0002-3898-0273Clarissa Severino Gamahttps://orcid.org/0000-0003-2235-9690Abstract Objective To investigate associations between body mass index (BMI), white matter fractional anisotropy (FA), and C-reactive protein (CRP) in a group of individuals with bipolar disorder (BD) during euthymia and compare them with a control group of healthy subjects (CTR). Methods The sample consisted of 101 individuals (BD n = 35 and CTR n = 66). Regions of interest (ROI) were defined using a machine learning approach. For each ROI, a regression model tested the association between FA and BMI, controlling for covariates. Peripheral CRP levels were assayed, correlated with BMI, and included in a mediation analysis. Results BMI predicted the FA of the right cingulate gyrus in BD (AdjR2 = 0.312 F(3) = 5.537 p = 0.004; β = -0.340 p = 0.034), while there was no association in CTR. There was an interaction effect between BMI and BD diagnosis (F(5) = 3.5857 p = 0.012; Fchange = 0.227 AdjR2 = 0.093; β = -1.093, p = 0.048). Furthermore, there was a positive correlation between BMI and CRP in both groups (AdjR2 = 0.170 F(3) = 7.337 p < 0.001; β = 0.364 p = 0.001), but it did not act as a mediator of the effect on FA. Conclusion Higher BMI is associated with right cingulate microstructure in BD, but not in CTR, and this effect could not be explained by inflammatory mediation alone.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892022000100416&tlng=enBipolar disorderobesitywhite matterdiffusion tensor imaging |
| spellingShingle | Ramiro Reckziegel Francisco Diego Rabelo-da-Ponte Jacson Gabriel Feiten Isadora Bosini Remus Pedro Domingues Goi Miréia Fortes Vianna-Sulzbach Raffael Massuda Danielle Macedo David de Lucena Letícia Sanguinetti Czepielewski Clarissa Severino Gama Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation Trends in Psychiatry and Psychotherapy Bipolar disorder obesity white matter diffusion tensor imaging |
| title | Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation |
| title_full | Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation |
| title_fullStr | Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation |
| title_full_unstemmed | Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation |
| title_short | Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation |
| title_sort | bipolar disorder an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation |
| topic | Bipolar disorder obesity white matter diffusion tensor imaging |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892022000100416&tlng=en |
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